Deciphering the chronology of copy number alterations in Multiple Myeloma

Abstract : Multiple myeloma (MM) and its precursor condition MGUS are characterized by chromosomal aberrations. Here, we comprehensively characterize the order of occurrence of these complex genomic events underlying MM development using 500 MGUS, and MM samples. We identify hyperdiploid MM (HMM) and non-HMM as genomically distinct entities with different evolution of the copy number alterations. In HMM, gains of 9,15 or 19 are the first and clonal events observed as clonal even at MGUS stage. These events are thus early and may underlie initial transformation of normal plasma cells to MGUS cells. However, CNAs may not be adequate for progression to MM except in 15% of the patients in whom the complex subclonal deletion events are observed in MM but not MGUS. In NHMM, besides the driver translocations, clonal deletion of 13 and 1q gain are early events also observed in MGUS. We combined this information to propose a timeline for copy number alteration.
Document type :
Journal articles
Complete list of metadatas

Cited literature [30 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-02290251
Contributor : Elizabeth Bernardo <>
Submitted on : Tuesday, September 17, 2019 - 3:04:15 PM
Last modification on : Wednesday, September 18, 2019 - 1:12:19 AM

File

Samur2019Eq11.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Anil Samur, Stephane Minvielle, Masood Shammas, Mariateresa Fulciniti, Florence Magrangeas, et al.. Deciphering the chronology of copy number alterations in Multiple Myeloma. Blood Cancer Journal, Nature Publishing Group, 2019, 9 (4), pp.39. ⟨10.1038/s41408-019-0199-3⟩. ⟨inserm-02290251⟩

Share

Metrics

Record views

44

Files downloads

39