I. Chen, E. Poirot, M. Newman, D. Kandula, R. Shah et al., An assessment of the supply, programmatic use, and regulatory issues of single low-dose primaquine as a plasmodium falciparum gametocytocide for sub-Saharan Africa, Malar J, vol.14, p.204, 2015.

L. J. Bolchoz, R. A. Budinsky, D. C. Mcmillan, and D. J. Jollow, Primaquine-induced hemolytic anemia: formation and hemotoxicity of the arylhydroxylamine metabolite 6-methoxy-8-hydroxylaminoquinoline, J Pharmacol Exp Ther, vol.297, issue.2, pp.509-524, 2001.

L. J. Bolchoz, J. D. Morrow, D. J. Jollow, and D. C. Mcmillan, Primaquine-induced hemolytic anemia: effect of 6-methoxy-8-hydroxylaminoquinoline on rat erythrocyte sulfhydryl status, membrane lipids, cytoskeletal proteins, and morphology, J Pharmacol Exp Ther, vol.303, issue.1, pp.141-149, 2002.

P. Arese, V. Gallo, A. Pantaleo, and F. Turrini, Life and death of Glucose-6-phosphate dehydrogenase (G6PD) deficient erythrocytes -role of redox stress and band 3 modifications, Transfus Med Hemother, vol.39, issue.5, pp.328-362, 2012.

H. Matsuoka, D. T. Thuan, H. Van-thien, T. Kanbe, A. Jalloh et al., Seven different glucose-6-phosphate dehydrogenase variants including a new variant distributed in lam Dong Province in southern Vietnam, Acta Med Okayama, vol.61, issue.4, pp.213-222, 2007.

H. Matsuoka, J. Wang, M. Hirai, M. Arai, S. Yoshida et al., Glucose-6-phosphate dehydrogenase (G6PD) mutations in Myanmar: G6PD Mahidol (487G>a) is the most common variant in the Myanmar population, J Hum Genet, vol.49, issue.10, pp.544-551, 2004.

S. Kim, C. Nguon, B. Guillard, S. Duong, S. Chy et al., Performance of the CareStart G6PD deficiency screening test, a point-of-care diagnostic for primaquine therapy screening, PLoS One, vol.6, issue.12, p.28357, 2011.
URL : https://hal.archives-ouvertes.fr/pasteur-00741113

R. E. Howes, K. E. Battle, A. W. Satyagraha, J. K. Baird, and S. I. Hay, G6PD deficiency: global distribution, genetic variants and primaquine therapy, Adv Parasitol, vol.81, pp.133-201, 2013.

E. Beutler, S. Duparc, and G. Group, Glucose-6-phosphate dehydrogenase deficiency and antimalarial drug development, Am J Trop Med Hyg, vol.77, issue.4, pp.779-89, 2007.

W. R. Taylor, H. Widjaja, H. Basri, E. Tjitra, C. Ohrt et al., Haemoglobin dynamics in Papuan and non-Papuan adults in Northeast Papua, Indonesia, with acute, uncomplicated vivax or falciparum malaria, Malar J, vol.12, p.209, 2013.

R. N. Price, J. A. Simpson, F. Nosten, C. Luxemburger, L. Hkirjaroen et al., Factors contributing to anemia after uncomplicated falciparum malaria, Am J Trop Med Hyg, vol.65, issue.5, pp.614-636, 2001.

S. Kheng, S. Muth, W. R. Taylor, N. Tops, K. Kosal et al., Tolerability and safety of weekly primaquine against relapse of plasmodium vivax in Cambodians with glucose-6-phosphate dehydrogenase deficiency, BMC Med, vol.13, p.203, 2015.

P. Charoenlarp, S. Areekul, T. Harinasuta, and P. Sirivorasarn, The haemolytic effect of a single dose of 45 mg of primaquine in G-6-PD deficient Thais, J Med Assoc Thail, vol.55, issue.11, pp.631-639, 1972.

W. D. Everett, A. Yoshida, and E. Pearlman, Hemoglobin E and glucose-6-phosphate deficiency in the Khmer air force (Cambodia), Am J Trop Med Hyg, vol.26, issue.4, pp.597-601, 1977.

S. S. Shah, A. Macharia, J. Makale, S. Uyoga, K. Kivinen et al., Genetic determinants of glucose-6-phosphate dehydrogenase activity in Kenya, BMC Med Genet, vol.15, p.93, 2014.

G. Bastiaens, A. B. Tiono, J. Okebe, H. E. Pett, S. A. Coulibaly et al., Safety of single lowdose primaquine in glucose-6-phosphate dehydrogenase deficient falciparum-infected African males: two open-label, randomized, safety trials, PLoS One, vol.13, issue.1, p.190272, 2018.

I. Chen, H. Diawara, A. Mahamar, K. Sanogo, S. Keita et al., Safety of single-dose Primaquine in G6PD-deficient and G6PD-Normal males in Mali without malaria: an open-label, phase 1, dose-adjustment trial, J Infect Dis, vol.217, issue.8, pp.1298-308, 2018.

R. C. Tine, K. Sylla, B. T. Faye, E. Poirot, F. B. Fall et al., Safety and efficacy of adding a single low dose of Primaquine to the treatment of adult patients with plasmodium falciparum malaria in Senegal, to reduce gametocyte carriage: a randomized controlled trial, Clin Infect Dis, vol.65, issue.4, pp.535-578, 2017.

R. Mwaiswelo, B. E. Ngasala, I. Jovel, R. Gosling, Z. Premji et al., Safety of a single low-dose of primaquine in addition to standard artemether-lumefantrine regimen for treatment of acute uncomplicated plasmodium falciparum malaria in Tanzania, Malar J, vol.15, p.316, 2016.

S. Shekalaghe, C. Drakeley, R. Gosling, A. Ndaro, M. Van-meegeren et al., Primaquine clears submicroscopic plasmodium falciparum gametocytes that persist after treatment with sulphadoxine-pyrimethamine and artesunate, PLoS One, vol.2, issue.10, p.1023, 2007.

S. A. Shekalaghe, R. Ter-braak, M. Daou, R. Kavishe, W. Van-den-bijllaardt et al., In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenasedeficient (G6PD A-) individuals, Antimicrob Agents Chemother, vol.54, issue.5, pp.1762-1770, 2010.

B. P. Goncalves, A. B. Tiono, A. Ouedraogo, W. M. Guelbeogo, J. Bradley et al., Single low dose primaquine to reduce gametocyte carriage and plasmodium falciparum transmission after artemether-lumefantrine in children with asymptomatic infection: a randomised, double-blind, placebo-controlled trial, BMC Med, vol.14, p.40, 2016.

G. Bancone, N. Chowwiwat, R. Somsakchaicharoen, L. Poodpanya, P. K. Moo et al., Single low dose Primaquine (0.25 mg/kg) does not cause clinically significant Haemolysis in G6PD deficient subjects, PLoS One, vol.11, issue.3, p.151898, 2016.

J. T. Lin, C. Lon, M. D. Spring, S. Sok, S. Chann et al., Single dose primaquine to reduce gametocyte carriage and plasmodium falciparum transmission in Cambodia: an open-label randomized trial, PLoS One, vol.12, issue.6, p.168702, 2017.

F. Smithuis, M. K. Kyaw, O. Phe, T. Win, P. P. Aung et al., Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial, Lancet Infect Dis, vol.10, issue.10, pp.673-81, 2010.

S. Heng, L. Durnez, S. Mao, S. Siv, S. Tho et al., Passive case detection of malaria in Ratanakiri Province (Cambodia) to detect villages at higher risk for malaria, Malar J, vol.16, issue.1, p.104, 2017.

N. Khim, C. Benedet, S. Kim, S. Kheng, S. Siv et al., G6PD deficiency in plasmodium falciparum and plasmodium vivax malaria-infected Cambodian patients, Malar J, vol.12, p.171, 2013.

A. Roca-feltrer, N. Khim, S. Kim, S. Chy, L. Canier et al., Field trial evaluation of the performances of point-of-care tests for screening G6PD deficiency in Cambodia, PLoS One, vol.9, issue.12, p.116143, 2014.

P. Hillmen, C. Hall, J. C. Marsh, M. Elebute, M. P. Bombara et al., Effect of eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal hemoglobinuria, N Engl J Med, vol.350, issue.6, pp.552-561, 2004.

A. Sowunmi, G. O. Gbotosho, C. T. Happi, and B. A. Fateye, Factors contributing to anaemia after uncomplicated plasmodium falciparum malaria in children, Acta Trop, vol.113, issue.2, pp.155-61, 2010.

R. E. Phillips and G. Pasvol, Anaemia of Plasmodium falciparum malaria, Baillieres Clin Haematol, vol.5, issue.2, pp.315-345, 1992.

M. Imwong, T. T. Hien, N. T. Thuy-nhien, A. M. Dondorp, and N. J. White, Spread of a single multidrug resistant malaria parasite lineage (PfPailin) to Vietnam, Lancet Infect Dis, vol.17, issue.10, pp.1022-1025, 2017.

C. Amaratunga, P. Lim, S. Suon, S. Sreng, S. Mao et al., Dihydroartemisinin-piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study, Lancet Infect Dis, vol.16, issue.3, pp.357-65, 2016.

B. Witkowski, V. Duru, N. Khim, L. S. Ross, B. Saintpierre et al., A surrogate marker of piperaquine-resistant plasmodium falciparum malaria: a phenotype-genotype association study, Lancet Infect Dis, vol.17, issue.2, pp.174-83, 2017.
URL : https://hal.archives-ouvertes.fr/pasteur-01400955

S. Pukrittayakamee, K. Chotivanich, A. Chantra, R. Clemens, S. Looareesuwan et al., Activities of artesunate and primaquine against asexual-and sexual-stage parasites in falciparum malaria, Antimicrob Agents Chemother, vol.48, issue.4, pp.1329-1363, 2004.

J. Arnold, A. S. Alving, R. S. Hockwald, C. B. Clayman, R. J. Dern et al., The antimalarial action of primaquine against the blood and tissue stages of falciparum malaria (Panama, P-F-6 strain), J Lab Clin Med, vol.46, issue.3, pp.391-398, 1955.

C. B. Clayman, J. Arnold, R. S. Hockwald, E. H. Yount, J. H. Edgcomb et al., Toxicity of primaquine in Caucasians, J Am Med Assoc, vol.149, issue.17, pp.1563-1571, 1952.

R. O. Wright, W. J. Lewander, and A. D. Woolf, Methemoglobinemia: etiology, pharmacology, and clinical management, Ann Emerg Med, vol.34, issue.5, pp.646-56, 1999.

G. Bancone, C. S. Chu, R. Somsakchaicharoen, N. Chowwiwat, D. M. Parker et al., Characterization of G6PD genotypes and phenotypes on the northwestern Thailand-Myanmar border, PLoS One, vol.9, issue.12, p.116063, 2014.

R. Leang, N. H. Khu, M. Mukaka, M. Debackere, R. Tripura et al., An optimised age-based dosing regimen for single low-dose primaquine for blocking malaria transmission in Cambodia, BMC Med, vol.14, issue.1, p.171, 2016.
URL : https://hal.archives-ouvertes.fr/pasteur-01739357