A Functional Assay to Determine the Capacity of Oncolytic Viruses to Induce Immunogenic Tumor Cell Death - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Methods in Molecular Biology Year : 2020

A Functional Assay to Determine the Capacity of Oncolytic Viruses to Induce Immunogenic Tumor Cell Death

Abstract

Oncolytic immunotherapy efficacy relies partially on the induction of immunogenic tumor cell death following infection with oncolytic viruses (OV) to induce an antitumor immune response. Here, we describe a method to determine if an OV is able to induce such an immunogenic tumor cell death. This method consists in testing whether tumor cells lysed by an OV are able to induce the maturation of human monocyte-derived immature dendritic cells (Mo-iDC).
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Dates and versions

inserm-02285959 , version 1 (13-09-2019)

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Tiphaine Delaunay, Carole Achard, Marc Gregoire, Frédéric Tangy, Nicolas Boisgerault, et al.. A Functional Assay to Determine the Capacity of Oncolytic Viruses to Induce Immunogenic Tumor Cell Death. Methods in Molecular Biology, 2020, 2058, pp.127-132. ⟨10.1007/978-1-4939-9794-7_8⟩. ⟨inserm-02285959⟩
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