Unique and specific Agrobacterium diversity in urinary microbiota of tolerant kidney transplanted recipients

Abstract : Host‐microbiota interactions can modulate the immune system both at local and systemic levels, with potential consequences for organ transplantation outcomes. In this study, we hypothesized that differences in the urinary microbiome following kidney transplantation would be associated with posttransplantation status: stable, minimally immunosuppressed, or tolerant. One hundred thirteen urine samples from stable (n = 51), minimally immunosuppressed (n = 19), and spontaneously tolerant (n = 16) patients, paired with age‐matched controls (n = 27) were profiled and compared to each other at a taxonomic level with special interest in the immunosuppressive regimen. All comparisons and correlations were adjusted on sex and time posttransplantation. Our results highlighted a unique and specific urinary microbiota associated with spontaneous tolerance characterized by a high diversity and a clear Proteobacteria profile. Finally, we report that this profile is (1) impacted by gender, (2) inversely correlated with immunosuppressive drugs (calcineurin inhibitors and mammalian target of rapamycin inhibitors), and (3) stable in time.
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https://www.hal.inserm.fr/inserm-02285840
Contributor : Ana Paula Dutra Azevedo <>
Submitted on : Friday, September 13, 2019 - 10:37:34 AM
Last modification on : Sunday, September 15, 2019 - 1:10:09 AM

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Luc Colas, Emmanuel Mongodin, Emmanuel Montassier, Mélanie Chesneau, Pierrick Guérif, et al.. Unique and specific Agrobacterium diversity in urinary microbiota of tolerant kidney transplanted recipients. American Journal of Transplantation, Wiley, 2019, ⟨10.1111/ajt.15549⟩. ⟨inserm-02285840⟩

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