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Journal articles
Fulminant arterial vasculitis as an unusual complication of disseminated staphylococcal disease due to the emerging CC1 methicillin-susceptible Staphylococcus aureus clone: a case report
Abstract : BACKGROUND:
Staphylococcus aureus has emerged as a leading cause of invasive severe diseases with a high rate of morbidity and mortality worldwide. The wide spectrum of clinical manifestations and outcome observed in staphylococcal illness may be a consequence of both microbial factors and variability of the host immune response.
CASE PRESENTATION:
A 14-years old child developed limb ischemia with gangrene following S. aureus bloodstream infection. Histopathology revealed medium-sized arterial vasculitis. The causing strain belonged to the emerging clone CC1-MSSA and numerous pathogenesis-related genes were identified. Patient's genotyping revealed functional variants associated with severe infections. A combination of virulence and host factors might explain this unique severe form of staphylococcal disease.
CONCLUSION:
A combination of virulence and genetic host factors might explain this unique severe form of staphylococcal disease.
Cited literature [19 references]
https://www.hal.inserm.fr/inserm-02285428
Contributor : Myriam Bodescot <>
Submitted on : Thursday, September 12, 2019 - 4:48:34 PM
Last modification on : Friday, July 16, 2021 - 4:36:02 PM
Long-term archiving on: : Saturday, February 8, 2020 - 5:57:47 AM
Contributor : Myriam Bodescot <>
Submitted on : Thursday, September 12, 2019 - 4:48:34 PM
Last modification on : Friday, July 16, 2021 - 4:36:02 PM
Long-term archiving on: : Saturday, February 8, 2020 - 5:57:47 AM
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s12879-019-3933-3.pdf
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