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Viral and tumor antigen-specific CD8 T-cell responses in Merkel cell carcinoma

Abstract : Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous cancer, which is immunogenic, regardless of the presence of MCPyV (80% of cases). The identification of MCC-specific epitopes recognized by CD8 T cells is crucial to expand the arsenal of immunotherapeutic treatments. Until now, most efforts focused on the identification of virus-specific epitopes, whereas immune responses directed against shared cellular tumor-specific antigens have not been evidenced. In this study, we measured T-cell responses against viral (n = 3) and tumor antigens (n = 47) from TILs derived from 21 MCC tumors. Virus-specific CD8 T-cell responses dominated MCC-specific immune responses, and we identified two new HLA-peptide complexes derived from the LT antigen, located in a region encompassing 3 previously identified epitopes. Finally, we show that MAGE-A3 antigen, frequently expressed by MCC tumors, was recognized by CD8 TILs from a virus-negative MCC tumor and thus could be a target for immunotherapy in this setting.
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Submitted on : Thursday, September 12, 2019 - 10:17:07 AM
Last modification on : Wednesday, September 7, 2022 - 11:32:04 AM


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Mahtab Samimi, Houssem Benlalam, Pascal Aumond, Pauline Gaboriaud, Delphine Fradin, et al.. Viral and tumor antigen-specific CD8 T-cell responses in Merkel cell carcinoma. Cellular Immunology, Elsevier, 2019, 344, 8 p. ⟨10.1016/j.cellimm.2019.103961⟩. ⟨inserm-02284748⟩



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