, with miR-320-3p or antagomiR-loaded DOSP nanoparticles or control buffer. (A) Note a higher ratio of polr3d for miR-320-p group against Control group ( * P = 0.05) at ZT-20H and the similarity of levels for AntagomiR and Control groups. In panel (B) parallel determinations of immune complexes H3K27me3 showed that only the antagomiR-320-3p group was slightly enriched in the polr3d promoter, FIGURE 6 | Difference between Chromatin-ImmunoPrecipitation done with anti-Trimethyl-histone-3-Lys4 or Lys-27 on gastric tissues of rat pups treated per os

S. Aten, K. F. Hansen, K. Snider, K. Wheaton, A. Kalidindi et al., miR-132 couples the circadian clock to daily rhythms of neuronal plasticity and cognition, Learn. Mem, vol.25, pp.214-229, 2018.

S. R. Baier, C. Nguyen, F. Xie, J. R. Wood, and J. Zempleni, MicroRNAs are absorbed in biologically meaningful amounts from nutritionally relevant doses of cow milk and affect gene expression in peripheral blood mononuclear cells, HEK-293 kidney cell cultures, and mouse livers, J. Nutr, vol.144, pp.1495-1500, 2014.

M. Benhamed, U. Herbig, T. Ye, A. Dejean, and O. Bischof, Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells, Nat. Cell Biol, vol.14, pp.266-275, 2012.

D. Beuzelin and B. Kaeffer, Exosomes and miRNA-loaded biomimetic nanovehicles, a focus on their potentials preventing type-2 diabetes linked to metabolic syndrome, Front. Immunol, vol.9, p.2711, 2018.

L. Billiet, J. P. Gomez, M. Brechet, P. A. Jaffres, L. Gall et al., Gene Transfer by chemical vectors: comparative study of the endocytosis routes of polyplexes, lipoplexes and lipopolyplexes in a myoblast cell line, Biomaterials, vol.33, pp.2980-2990, 2012.

E. R. Billinge, M. Broom, and M. Platt, Monitoring aptamer-protein interactions using tunable resistive pulse sensing, Anal. Chem, vol.86, pp.1030-1037, 2014.

J. F. Bowyer, M. Thomas, T. A. Patterson, N. I. George, J. A. Runnells et al., A visual description of the dissection of the cerebral surface vasculature and associated meninges and the choroid plexus from rat brain, J. Vis. Exp. e4285, 2012.

J. Brennecke, A. Stark, R. B. Russell, and S. M. Cohen, Principles of micro-RNA-target recognition, PLoS Biol, vol.3, p.85, 2005.

T. R. Cech and J. A. Steitz, The noncoding RNA revolution-trashing old rules to forge new ones, Cell, vol.157, pp.77-94, 2014.

T. Colombani, P. Peuziat, L. Dallet, T. Haudebourg, M. Mével et al., Self-assembling complexes between binary mixtures of lipids with different linkers and nucleic acids promote universal mRNA, DNA and siRNA delivery, J. Control Release, vol.249, pp.131-142, 2017.
URL : https://hal.archives-ouvertes.fr/inserm-01473687

B. Coupé, V. Amarger, I. Grit, A. Benani, and P. Parnet, Nutritional programming affects hypothalamic organization and early response to leptin, Endocrinology, vol.151, pp.702-713, 2010.

R. Denzler, V. Agarwal, J. Stefano, D. P. Bartel, and M. Stoffel, Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance, Mol. Cell, vol.54, pp.766-776, 2014.

L. Desigaux, M. Sainlos, O. Lambert, R. Chevre, E. Letrou-bonneval et al., Self-assembled lamellar complexes of siRNA with lipidic aminoglycoside derivatives promote efficient siRNA delivery and interference, Proc. Natl. Acad. Sci. U.S.A, vol.104, pp.16534-16539, 2007.

J. P. Etchegaray and R. Mostoslavsky, Interplay between metabolism and epigenetics: a nuclear adaptation to environmental changes, Mol. Cell, vol.62, pp.695-711, 2016.

B. Feng and S. Chakrabarti, miR-320 regulates glucose-induced gene expression in diabetes, ISRN Endocrinol, p.549875, 2012.

I. Floris, H. Billard, C. Y. Boquien, E. Joram-gauvard, L. Simon et al., MiRNA analysis by quantitative PCR in preterm human breast milk reveals daily fluctuations of hsa-miR-16-5p, PLoS One, vol.10, 2015.

J. Fox, The R commander: a basic statistics graphical user interface to R, J. Stat. Soft, vol.14, pp.1-42, 2005.

P. J. Greasley, C. Bonnard, A. , and B. , Myc induces the nucleolin and BN51 genes: possible implications in ribosome biogenesis, Nucleic Acids Res, vol.28, pp.446-453, 2000.

D. Habrant, P. Peuziat, T. Colombani, L. Dallet, J. Gehin et al., Design of ionizable lipids to overcome the limiting step of endosomal escape: application in the intracellular delivery of mRNA, DNA, and siRNA, J. Med. Chem, vol.59, pp.3046-3062, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01831743

E. W. Harville, S. Srinivasan, W. Chen, and G. S. Berenson, Is the metabolic syndrome a "small baby" syndrome?: the bogalusa heart study, Metab. Syndr. Relat. Disord, vol.10, pp.413-421, 2012.

F. He, E. Shi, L. Yan, J. Li, and X. Jiang, Inhibition of micro-ribonucleic acid-320 attenuates neurologic injuries after spinal cord ischemia, J. Thorac. Cardiovasc. Surg, vol.150, pp.398-406, 2015.

M. Hirsch and M. Helm, Live cell imaging of duplex siRNA intracellular trafficking, Nucleic Acids Res, vol.43, pp.4650-4660, 2015.

W. J. Huang, M. Li, X. H. Jin, X. J. Huang, W. Zhao et al., Genetic profile and biological implication of PIN2/TRF1-interacting telomerase inhibitor 1 (PinX1) in human cancers: an analysis using the cancer genome atlas, Oncotarget, vol.8, pp.67241-67253, 2017.

M. M. Ittmann, Cell cycle control of the BN51 cell cycle gene which encodes a subunit of RNA polymerase III, Cell Growth Differ, vol.5, pp.783-788, 1994.

C. Junien, P. Panchenko, L. Pirola, V. Amarger, B. Kaeffer et al., The new paradigm of the developmental origin of health and diseases (DOHaD)-Epigenetics and environment: evidence and missing links, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01850420

, Med. Sci, vol.32, pp.27-34

B. Kaeffer, A. Legrand, T. Moyon, A. Frondas-chauty, H. Billard et al., Non-invasive exploration of neonatal gastric epithelium by using exfoliated epithelial cells, PLoS One, vol.6, 2011.

R. Kalantari, C. M. Chiang, and D. R. Corey, Regulation of mammalian transcription and splicing by Nuclear RNAi, Nucleic Acids Res, vol.44, pp.524-537, 2016.

D. H. Kim, P. Saetrom, O. Snøve, and J. J. Rossi, MicroRNA-directed transcriptional gene silencing in mammalian cells, Proc. Natl. Acad. Sci. U.S.A, vol.105, pp.16230-16235, 2008.

D. H. Kim, Z. Tang, M. Shimada, B. Fierz, B. Houck-loomis et al., Histone H3K27 trimethylation inhibits H3 binding and function of SET1-like H3K4 methyltransferase complexes, Mol. Cell. Biol, vol.33, pp.4936-4946, 2013.

N. Kosaka, H. Izumi, K. Sekine, and T. Ochiya, microRNA as a new immune-regulatory agent in breast milk, Silence, vol.1, p.7, 2010.

L. Bihan, O. Chèvre, R. Mornet, S. Garnier, B. Pitard et al., Probing the in vitro mechanism of action of cationic lipid/DNA lipoplexes at a nanometric scale, Nucleic Acids Res, vol.39, pp.1595-1609, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00566862

Z. F. Li, Y. M. Liang, P. N. Lau, W. Shen, D. K. Wang et al., Dynamic localisation of mature microRNAs in human nucleoli is influenced by exogenous genetic materials, PLoS One, vol.8, p.70869, 2013.

W. F. Lima, T. P. Prakash, H. M. Murray, G. A. Kinberger, W. Li et al., Single-stranded siRNAs activate RNAi in animals, Cell, vol.150, pp.883-894, 2012.

Y. Liu, J. Lin, H. Tu, C. , and C. , Protecting against ischemic stroke in rats by heat shock protein-20-mediated exercise preconditioning, FASEB J, vol.29, 2015.

K. J. Livak and T. D. Schmittgen, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method, Methods, vol.25, pp.402-408, 2001.

A. Lucas, Role of nutritional programming in determining adult morbidity, Arch. Dis. Child, vol.71, pp.288-290, 1994.

A. Lukasik, I. Brzozowska, U. Zielenkiewicz, and P. Zielenkiewicz, Detection of plant miRNAs abundance in human breast milk, Int. J. Mol. Sci, vol.19, p.37, 2017.

R. C. Ma and B. M. Popkin, Intergenerational diabetes and obesity-A cycle to break, PLoS Med, vol.14, p.1002415, 2017.

Q. Mei, X. Li, Y. Meng, Z. Wu, M. Guo et al., A facile and specific assay for quantifying microRNA by an optimized RT-qPCR approach, PLoS One, vol.7, p.46890, 2012.

M. Mével, T. Haudebourg, T. Colombani, P. Peuziat, L. Dallet et al., Important role of phosphoramido linkage in imidazole-based dioleyl helper lipids for liposome satbility and primary cell transfection, J. Gene Med, vol.18, pp.3-15, 2016.

M. Mével, M. Sainlos, B. Chatin, N. Oudrhiri, M. Hauchecorne et al., Paromomycin and neomycin B derived cationic lipids: synthesis and transfection studies, J. Control Release, vol.158, pp.461-469, 2012.

F. F. Mo, T. An, Z. J. Zhang, Y. F. Liu, H. X. Liu et al., Jiang tang xiao ke granule play an anti-diabetic role in diabetic mice pancreatic tissue by regulating the mRNAs and microRNAs associated with PI3K-Akt signaling pathway, Front. Pharmacol, vol.8, p.795, 2017.

A. Montecalvo, A. T. Larregina, W. J. Shufesky, D. B. Stolz, M. L. Sullivan et al., Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes, Blood, vol.119, pp.756-766, 2012.

G. Mullokandov, A. Baccarini, A. Ruzo, A. D. Jayaprakash, N. Tung et al., High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries, Nat. Methods, vol.9, pp.840-846, 2012.

M. Olejniczak, P. Galka, and W. J. Krzyzosiak, Sequence-non-specific effects of RNA interference triggers and microRNA regulators, Nucleic Acids Res, vol.38, pp.1-16, 2010.

R. Orozco-solís, R. J. Matos, S. Lopes-de-souza, I. Grit, B. Kaeffer et al., Perinatal nutrient restriction induces long-lasting alterations in the circadian expression pattern of genes regulating food intake and energy metabolism, Int. J. Obes, vol.35, pp.990-1000, 2011.

X. P. Ren, J. Wu, X. Wang, M. A. Sartor, K. Jones et al., , 2009.

, MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20, Circulation, vol.119, pp.2357-2366

T. C. Roberts, The MicroRNA biology of the mammalian nucleus, Mol. Ther. Nucleic Acids, vol.3, p.188, 2014.

M. Sela, Y. Kloog, and O. Rechavi, Non-coding RNAs as the bridge between epigenetic mechanisms, lineages and domains of life, J. Physiol, vol.592, pp.2369-2373, 2014.

P. Sethupathy, The Promise and challenge of therapeutic microRNA silencing in diabetes and metabolic diseases, Curr. Diab. Rep, vol.16, p.52, 2016.

M. Sládek, Z. Jindráková, Z. Bendová, and A. Sumová, Postnatal ontogenesis of the circadian clock within the rat liver, Am. J. Physiol. Regul. Integr. Comp. Physiol, vol.292, pp.1224-1229, 2007.

C. A. Sledz, M. Holko, M. J. De-veer, R. H. Silverman, and B. R. Williams, Activation of the interferon system by short-interfering RNAs, Nat. Cell Biol, vol.5, pp.834-839, 2003.

L. Stevanato, L. Thanabalasundaram, N. Vysokov, and J. D. Sinden, Investigation of content, stoichiometry and transfer of miRNA from human neural stem cell line derived exosomes, PLoS One, vol.11, 2016.

A. Sumová, Z. Bendová, M. Sládek, R. El-hennamy, K. Laurinová et al., Setting the biological time in central and peripheral clocks during ontogenesis, FEBS Lett, vol.580, pp.2836-2842, 2006.

A. Turchinovich and B. Burwinkel, Distinct AGO1 and AGO2 associated miRNA profiles in human cells and blood plasma, RNA Biol, vol.9, pp.1066-1075, 2012.

S. Vasudevan, Y. Tong, and J. A. Steitz, Switching from repression to activation: microRNAs can up-regulate translation, Science, vol.318, pp.1931-1934, 2007.

J. A. Vidigal and A. Ventura, The biological functions of miRNAs: lessons from in vivo studies, Trends Cell Biol, vol.25, pp.137-147, 2015.

K. Wang, Y. Yuan, J. H. Cho, S. Mcclarty, D. Baxter et al., Comparing the MicroRNA spectrum between serum and plasma, PLoS One, vol.7, p.41561, 2012.

C. I. Wu, Y. Shen, and T. Tang, Evolution under canalization and the dual roles of microRNAs: a hypothesis, Genome Res, vol.19, pp.734-743, 2009.

X. Xie, J. Lu, E. J. Kulbokas, T. R. Golub, V. Mootha et al., Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals, Nature, vol.434, pp.338-345, 2005.

J. Zangari, M. Ilie, F. Rouaud, L. Signetti, M. Ohanna et al., Rapid decay of engulfed extracellular miRNA by XRN1 exonuclease promotes transient epithelial-mesenchymal transition, Nucleic Acids Res, vol.45, pp.4131-4141, 2017.

Q. Zhou, M. Li, X. Wang, Q. Li, T. Wang et al., Immune-related MicroRNAs are abundant in breast milk exosomes, Int. J. Biol. Sci, vol.8, pp.118-123, 2012.