R. Albulescu, E. Codrici, I. D. Popescu, S. Mihai, L. G. Necula et al., Cytokine patterns in brain tumour progression, Mediators Inflamm, p.979748, 2013.

A. Bakshi, T. C. Nag, S. Wadhwa, A. K. Mahapatra, and C. Sarkar, The expression of nitric oxide synthases in human brain tumours and peritumoral areas, J. Neurol. Sci, vol.155, pp.196-203, 1998.

R. F. Barth and B. Kaur, Rat brain tumor models in experimental neuro-oncology: the C6, 9L, T9, RG2, F98, BT4C, RT-2 and CNS-1 gliomas, J. Neurooncol, vol.94, pp.299-312, 2009.

A. Y. Bekker, A. B. Ritter, and W. N. Duran, Analysis of microvascular permeability to macromolecules by video-image digital processing, Microvas. Res, vol.38, pp.200-216, 1989.

S. Ben-lulu, T. Ziv, P. Weisman-shomer, and M. Benhar, Nitrosothioltrapping-based proteomic analysis of s-nitrosylation in human lung carcinoma cells, PLoS One, vol.12, 2017.

H. Broholm, I. Rubin, A. Kruse, O. Braendstrup, K. Schmidt et al., Nitric oxide synthase expression and enzymatic activity in human brain tumors, Clin. Neuropathol, vol.22, pp.273-281, 2003.

Y. J. Chen, W. C. Ching, J. S. Chen, T. Y. Lee, C. T. Lu et al., Decoding the s-nitrosoproteomic atlas in individualized human colorectal cancer tissues using a label-free quantitation strategy, J. Proteome Res, vol.13, pp.4942-4958, 2014.

C. S. Cobbs, J. E. Brenman, K. D. Aldape, D. S. Bredt, and M. A. Israel, Expression of nitric oxide synthase in human central nervous system tumors, Cancer Res, vol.55, pp.727-730, 1995.

L. G. Dubois, L. Campanati, C. Righy, I. D'andrea-meira, T. C. Spohr et al., Gliomas and the vascular fragility of the blood brain barrier, Front. Cell Neurosci, vol.8, p.418, 2014.

H. F. Dvorak, J. A. Nagy, J. T. Dvorak, and A. M. Dvorak, Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules, Am. J. Pathol, vol.133, pp.95-109, 1988.

J. Dwyer, J. K. Hebda, A. Le-guelte, E. M. Galan-moya, S. S. Smith et al., Glioblastoma cell-secreted interleukin-8 induces brain endothelial cell permeability via CXCR2, PloS One, vol.7, p.45562, 2012.

C. J. Edgell, C. C. Mcdonald, and J. B. Graham, Permanent cell line expressing human factor VIII-related antigen established by hybridization, Proc. Natl. Acad. Sci. U. S. A, vol.80, pp.3734-3737, 1983.

O. Feron and J. L. Balligand, Caveolins and the regulation of endothelial nitric oxide synthase in the heart, Cardiovasc. Res, vol.69, pp.788-797, 2006.

D. Garbossa, M. Fontanella, C. A. Pagni, and A. Vercelli, Nitric oxide synthase and cytochrome c oxidase changes in the tumoural and peritumoural cerebral cortex, Acta Neurochi, vol.143, pp.897-908, 2001.

J. Gavard, X. Hou, Y. Qu, A. Masedunskas, D. Martin et al., A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability, Mol. Cell. Biol, vol.29, pp.2469-2480, 2009.

M. Giannotta, M. Trani, and E. Dejana, VE-cadherin and endothelial adherens junctions: active guardians of vascular integrity, Dev. Cell, vol.26, pp.441-454, 2013.

J. P. Gratton, M. I. Lin, J. Yu, E. D. Weiss, Z. L. Jiang et al., Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice, Cancer Cell, vol.4, pp.168-173, 2003.

A. Guequen, R. Carrasco, P. Zamorano, L. Rebolledo, P. Burboa et al., S-nitrosylation regulates VE-cadherin phosphorylation and internalization in microvascular permeability, Am. J. Physiol. Heart Circ. Physiol, vol.310, 2016.

D. Haas-kogan, N. Shalev, M. Wong, G. Mills, G. Yount et al., Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC, Curr. Biol, vol.8, pp.1195-1198, 1998.

T. Hatakeyama, P. J. Pappas, R. W. Hobson, . Ii, M. P. Boric et al., Endothelial nitric oxide synthase regulates microvascular hyperpermeability in vivo, J. Physiol, vol.574, pp.275-281, 2006.

L. S. Heuser, F. N. Miller, and C. Gilley-pietsch, Protein leak from normal vasculature due to human malignant ascites, Am. J. Surg, vol.155, pp.765-769, 1988.

P. C. Huszthy, I. Daphu, S. P. Niclou, D. Stieber, J. M. Nigro et al., In vivo models of primary brain tumors: pitfalls and perspectives, Neuro. Oncol, vol.14, pp.979-993, 2012.

Y. Iwakiri, A. Satoh, S. Chatterjee, D. K. Toomre, C. M. Chalouni et al., Nitric oxide synthase generates nitric oxide locally to regulate compartmentalized protein Snitrosylation and protein trafficking, Proc. Natl. Acad. Sci. U. S. A, vol.103, pp.19777-19782, 2006.

S. R. Jaffrey and S. H. Snyder, The biotin switch method for the detection of S-nitrosylated proteins, Sci. STKE, p.1, 2001.

R. K. Jain, E. Di-tomaso, D. G. Duda, J. S. Loeffler, A. G. Sorensen et al., Angiogenesis in brain tumours, Nat. Rev. Neurosci, vol.8, pp.610-622, 2007.

P. R. Joseph, J. M. Sarmiento, A. K. Mishra, S. T. Das, R. P. Garofalo et al., Probing the role of CXC motif in chemokine CXCL8 for high affinity binding and activation of CXCR1 and CXCR2 receptors, J. Biol. Chem, vol.285, pp.29262-29269, 2010.

P. Kubes and D. N. Granger, Nitric oxide modulates microvascular permeability, Am. J. Physiol, vol.262, issue.2, pp.611-615, 1992.

I. Kurose, P. Kubes, R. Wolf, D. C. Anderson, J. Paulson et al., Inhibition of nitric oxide production. Mechanisms of Vascular Albumin Leakage, Circ. Res, vol.73, pp.164-171, 1993.

Y. W. Lam, Y. Yuan, J. Isaac, C. V. Babu, J. Meller et al., Comprehensive identification and modified-site mapping of S-nitrosylated targets in prostate epithelial cells, PLoS One, vol.5, p.9075, 2010.

J. Li, C. Yen, D. Liaw, K. Podsypanina, S. Bose et al., PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer, Science, vol.275, pp.1943-1947, 1997.

S. K. Lim, S. R. Llaguno, R. M. Mckay, and L. F. Parada, Glioblastoma multiforme: a perspective on recent findings in human cancer and mouse models, BMB Rep, vol.44, p.158, 2011.

N. Marin, P. Zamorano, R. Carrasco, P. Mujica, F. G. Gonzalez et al., S-Nitrosation of beta-catenin and p120 catenin: a novel regulatory mechanism in endothelial hyperpermeability, Circul. Res, vol.111, pp.553-563, 2012.

R. Masood, J. Cai, A. Tulpule, T. Zheng, A. Hamilton et al., Interleukin 8 is an autocrine growth factor and a surrogate marker for Kaposi's sarcoma, Clin. Cancer Res, vol.7, pp.2693-2702, 2001.

T. Moldogazieva, S. Lutsenko, and A. Terentiev, Reactive oxygen and nitrogen species-induced protein modifications: implication in carcinogenesis and anticancer therapy, Cancer Res, vol.78, pp.6040-6047, 2018.

B. A. Nanes, C. Chiasson-mackenzie, A. M. Lowery, N. Ishiyama, V. Faundez et al., p120-catenin binding masks an endocytic signal conserved in classical cadherins, J. Cell Biol, vol.199, pp.365-380, 2012.

D. Predescu, S. Predescu, J. Shimizu, K. Miyawaki-shimizu, and A. B. Malik, Constitutive eNOS-derived nitric oxide is a determinant of endothelial junctional integrity, Am. J. Physiol. Lung Cell. Mol. Physiol, vol.289, pp.371-381, 2005.

M. Y. Radeva and J. Waschke, Mind the gap: mechanisms regulating the endothelial barrier, Acta Physiol, vol.222, p.12860, 2017.

M. A. Rahman, T. Senga, S. Ito, T. Hyodo, H. Hasegawa et al., S-nitrosylation at cysteine 498 of c-Src tyrosine kinase regulates nitric oxide-mediated cell invasion, J. Biol. Chem, vol.285, pp.3806-3814, 2009.

R. Rahman, S. Smith, C. Rahman, and R. Grundy, Antiangiogenic therapy and mechanisms of tumor resistance in malignant glioma, J. Oncol, p.16, 2010.

F. A. Sanchez, D. D. Kim, R. G. Duran, C. J. Meininger, and W. N. Duran, Internalization of eNOS via caveolae regulates PAF-induced inflammatory hyperpermeability to macromolecules, Am. J. Physiol. Heart Circ. Physiol, vol.295, 2008.

F. A. Sanchez, R. Rana, D. D. Kim, T. Iwahashi, R. Zheng et al., Internalization of eNOS and NO delivery to subcellular targets determine agonist-induced hyperpermeability, Proc. Nat. Acad. Sci. U. S. A, vol.106, pp.6849-6853, 2009.

F. A. Sánchez, N. B. Savalia, R. G. Durán, B. K. Lal, M. P. Boric et al., Functional significance of differential eNOS translocation, Am. J. Physiol. Heart Circ. Physiol, vol.29, pp.1058-1064, 2006.

X. Shen, M. A. Burguillos, A. M. Osman, J. Frijhoff, A. Carrillo-jimenez et al., Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype, Nat. Immunol, vol.17, pp.1282-1290, 2016.

A. G. Sorensen, T. T. Batchelor, W. T. Zhang, P. J. Chen, P. Yeo et al., A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients, Cancer Res, vol.69, pp.5296-5300, 2009.

J. S. Stamler, D. I. Simon, J. A. Osborne, M. E. Mullins, O. Jaraki et al., S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds, Proc. Natl. Acad. Sci. U. S. A, vol.89, pp.444-448, 1992.

G. R. Swaroop, P. A. Kelly, H. S. Bell, J. Shinoda, S. Yamaguchi et al., The effects of chronic nitric oxide synthase suppression on glioma pathophysiology, Br. J. Neurosurg, vol.14, pp.543-548, 2000.

C. H. Switzer, L. A. Ridnour, R. Cheng, J. Heinecke, A. Burke et al., S-Nitrosation Mediates Multiple Pathways That Lead to Tumor Progression in Estrogen Receptor-Negative Breast, For. Immunopathol. Dis. Therap, vol.3, pp.117-124, 2012.

S. Thibeault, Y. Rautureau, M. Oubaha, D. Faubert, B. C. Wilkes et al., S-nitrosylation of beta-catenin by eNOS-derived NO promotes VEGF-induced endothelial cell permeability, Mol. Cell, vol.39, pp.468-476, 2011.

A. Torres, Y. Vargas, D. Uribe, C. Jaramillo, A. Gleisner et al., Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells, Oncotarget, vol.7, pp.67373-67386, 2016.

Á. S. Torres, J. I. Erices, D. A. Uribe, J. Howden, I. Niechi et al., Current therapeutic alternatives and new perspectives in glioblastoma multiforme, Curr. Med. Chem, vol.24, pp.2781-2795, 2017.

W. I. Weis and W. J. Nelson, Re-solving the cadherin-catenin-actin conundrum, J. Biol. Chem, vol.281, pp.35593-35597, 2006.

M. J. White, F. N. Miller, L. S. Heuser, and C. Gilley-pietsch, Human malignant ascites and histamine-induced protein leakage from the normal microcirculation, Microvasc. Res, vol.35, pp.63-72, 1988.

C. Yu, S. Li, and A. R. Whorton, Redox regulation of PTEN by S-nitrosothiols, Mol. Pharmacol, vol.68, pp.847-854, 2005.

P. Zamorano, T. Koning, C. Oyanadel, G. A. Mardones, P. Ehrenfeld et al., Galectin-8 induces endothelial hyperpermeability through the eNOS pathway involving S-nitrosylation-mediated adherens junction disassembly, Carcinogenesis, vol.40, pp.313-323, 2019.

P. Zamorano, N. Marín, F. Córdova, A. Aguilar, C. Meininger et al., S-nitrosylation of VASP at cysteine 64 mediates the inflammationstimulated increase in microvascular permeability, Am. J. Physiol. Heart Circ. Physiol, vol.313, 2017.