Circulating and disseminated tumor cells: diagnostic tools and therapeutic targets in motion, Oncotarget, vol.8, pp.1884-1912, 2017. ,
Cancer stem cells (CSCs) in drug resistance and their therapeutic implications in cancer treatment, Stem Cell. Int, p.5416923, 2018. ,
Dormancy signatures and metastasis in estrogen receptor positive and negative breast cancer, PLoS One, vol.7, 2012. ,
A matter of life and death: stem cell survival in tissue regeneration and tumour formation, Nat. Rev. Cancer, vol.18, pp.187-201, 2018. ,
Mechanisms of cancer cell dormancy-another hallmark of cancer?, Cancer Res, vol.75, pp.5014-5022, 2015. ,
Cancer stem cells, cancer cell plasticity and radiation therapy, Semin. Cancer Biol, vol.31, pp.28-35, 2015. ,
Therapy-induced senescence in cancer, J. Natl. Cancer Inst, vol.102, pp.1536-1546, 2010. ,
Tumor cell escape from therapyinduced senescence as a model of disease recurrence after dormancy, Cancer Res, 2019. ,
Cellular senescence: the sought or the unwanted?, Trends Mol. Med, vol.24, pp.871-885, 2018. ,
Identification of novel candidates for replicative senescence by functional proteomics, Oncogene, vol.21, pp.4403-4413, 2002. ,
Differential proteome analysis of replicative senescence in rat embryo fibroblasts, Mol. Cell. Proteom, vol.1, pp.280-292, 2002. ,
Microarray analysis of replicative senescence, Curr. Biol, vol.9, pp.939-945, 1999. ,
Senescence-associated secretory phenotypes reveal cellnonautonomous functions of oncogenic RAS and the p53 tumor suppressor, PLoS Biol, vol.6, pp.2853-2868, 2008. ,
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence, Cell, vol.113, pp.703-716, 2003. ,
Cellular senescence and its effector programs, Genes Dev, vol.28, pp.99-114, 2014. ,
Definition of pRB-and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci, Mol. Cell. Biol, vol.27, pp.2452-2465, 2007. ,
Replicative senescence: a critical review, Mech. Ageing Dev, vol.125, pp.827-848, 2004. ,
Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence, Biochem. J, vol.376, pp.403-411, 2003. ,
The unfolded protein response and cellular senescence. A review in the theme: cellular mechanisms of endoplasmic reticulum stress signaling in health and disease, Am. J. Physiol. Cell Physiol, vol.308, pp.415-425, 2015. ,
Senescent keratinocytes die by autophagic programmed cell death, Am. J. Pathol, vol.174, pp.423-435, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-01260066
Cellular senescence: molecular mechanisms, in vivo significance, and redox considerations, Antioxidants Redox Signal, vol.11, pp.59-98, 2009. ,
Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells, Nat. Commun, vol.7, p.10399, 2016. ,
Apoptosis in proliferating, senescent, and immortalized keratinocytes, J. Biol. Chem, vol.274, pp.23358-23367, 1999. ,
Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved, Cancer Res, vol.55, pp.2284-2292, 1995. ,
A biomarker that identifies senescent human cells in culture and in aging skin in vivo, Proc. Natl. Acad. Sci. U.S.A, vol.92, pp.9363-9367, 1995. ,
Senescence-associated beta-galactosidase is lysosomal beta-galactosidase, Aging Cell, vol.5, pp.187-195, 2006. ,
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors, Cell, vol.120, pp.513-522, 2005. ,
The senescence-stemness alliance -a cancerhijacked regeneration principle, Trends Cell Biol, vol.28, pp.1049-1061, 2018. ,
DNA methylation of the Oct4A enhancers in embryonal carcinoma cells after etoposide treatment is associated with alternative splicing and altered pluripotency in reversibly senescent cells, Cell Cycle, vol.17, pp.362-366, 2018. ,
Drug-induced senescence generates chemoresistant stemlike cells with low reactive oxygen species, J. Biol. Chem, vol.286, pp.37813-37829, 2011. ,
Induction of cancer cell stemness by chemotherapy, Cell Cycle, vol.11, pp.2691-2698, 2012. ,
Some chemotherapeutics-treated colon cancer cells display a specific phenotype being a combination of stem-like and senescent cell features, Cancer Biol. Ther, vol.19, pp.63-75, 2018. ,
Selfrenewal signalling in presenescent tetraploid IMR90 cells, J Aging Res, 2011. ,
Senescenceassociated heterochromatin foci are dispensable for cellular senescence, occur in a cell type-and insult-dependent manner and follow expression of p16(ink4a), Cell Cycle, vol.10, pp.457-468, 2011. ,
The limited in vitro lifetime of human diploid cell strains, Exp. Cell Res, vol.37, pp.614-636, 1965. ,
The signals and pathways activating cellular senescence, Int. J. Biochem. Cell Biol, vol.37, pp.961-976, 2005. ,
The essence of senescence, Genes Dev, vol.24, pp.2463-2479, 2010. ,
Cancer cell senescence: a new frontier in drug development, Drug Discov. Today, vol.17, pp.269-276, 2012. ,
Comparison of replicative senescence and stress-induced premature senescence combining differential display and low-density DNA arrays, FEBS Lett, vol.579, pp.3651-3659, 2005. ,
Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes, Exp. Gerontol, vol.35, pp.927-945, 2000. ,
Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts, Free Radic, Biol. Med, vol.28, pp.64-74, 2000. ,
Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing, Curr. Opin. Genet. Dev, vol.26, pp.89-95, 2014. ,
Epithelial cell senescence: an adaptive response to pre-carcinogenic stresses?, Cell. Mol. Life Sci, 2017. ,
BRAFE600-associated senescence-like cell cycle arrest of human naevi, Nature, vol.436, pp.720-724, 2005. ,
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a, Cell, vol.88, pp.593-602, 1997. ,
Involvement of Rel/nuclear factor-kappaB transcription factors in keratinocyte senescence, Cancer Res, vol.64, pp.472-481, 2004. ,
Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts, Cancer Res, vol.59, pp.1539-1543, 1999. ,
Four faces of cellular senescence, J. Cell Biol, vol.192, pp.547-556, 2011. ,
The identification of senescence-specific genes during the induction of senescence in prostate cancer cells, Neoplasia, vol.7, pp.816-823, 2005. ,
DNA damage is able to induce senescence in tumor cells in vitro and in vivo, Cancer Res, vol.62, pp.1876-1883, 2002. ,
A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents, Cancer Res, vol.59, pp.3761-3767, 1999. ,
Irinotecan treatment and senescence failure promote the emergence of more transformed and invasive cells that depend on anti-apoptotic Mcl-1, Oncotarget, vol.6, pp.409-426, 2015. ,
Living on a break: cellular senescence as a DNA-damage response, Nat. Rev. Cancer, vol.8, pp.512-522, 2008. ,
Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation, Biochem. Pharmacol, vol.76, pp.947-957, 2008. ,
Escape from p21-mediated oncogene-induced senescence leads to cell dedifferentiation and dependence on anti-apoptotic Bcl-xL and MCL1 proteins, J. Biol. Chem, vol.286, pp.12825-12838, 2011. ,
A multi-stage process including transient polyploidization and EMT precedes the emergence of chemoresistent ovarian carcinoma cells with a dedifferentiated and pro-inflammatory secretory phenotype, Oncotarget, vol.6, pp.40005-40025, 2015. ,
Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin, J. Biol. Chem, vol.277, pp.17154-17160, 2002. ,
Downregulation of caveolin-1 affects bleomycin-induced growth arrest and cellular senescence in A549 cells, Int. J. Biochem. Cell Biol, vol.39, pp.1964-1974, 2007. ,
Cyclophosphamide induces premature senescence in normal human fibroblasts by activating MAP kinases, Biogerontology, vol.10, pp.677-682, 2009. ,
miR-290 acts as a physiological effector of senescence in mouse embryo fibroblasts, Physiol. Genom, vol.39, pp.210-218, 2009. ,
Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells, Biochem. Pharmacol, vol.90, pp.265-275, 2014. ,
Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers, Cancer Res, vol.65, pp.2795-2803, 2005. ,
Induction of senescence markers after neo-adjuvant chemotherapy of malignant pleural mesothelioma and association with clinical outcome: an exploratory analysis, Eur. J. Cancer, vol.47, pp.326-332, 2011. ,
Cellular senescence promotes adverse effects of chemotherapy and cancer relapse, Cancer Discov, vol.7, pp.165-176, 2017. ,
Cellular senescence: a translational perspective, EBioMedicine, vol.21, pp.21-28, 2017. ,
Senescence and senotherapeutics: a new field in cancer therapy, Pharmacol. Ther, 2018. ,
, Metastatic behavior of human breast carcinomas overexpressing the Bcl-x(L) gene: a role in dormancy and organospecificity, vol.81, pp.725-734, 2001.
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs, Aging Cell, vol.14, pp.644-658, 2015. ,
Transcriptional switch of dormant tumors to fast-growing angiogenic phenotype, Cancer Res, vol.69, pp.836-844, 2009. ,
MnSOD upregulation induces autophagic programmed cell death in senescent keratinocytes, PLoS One, vol.5, p.12712, 2010. ,
Level of macroautophagy drives senescent keratinocytes into cell death or neoplastic evasion, Cell Death Dis, vol.5, p.1577, 2014. ,
The autophagy-senescence connection in chemotherapy: must tumor cells (self) eat before they sleep?, J. Pharmacol. Exp. Ther, vol.343, pp.763-778, 2012. ,
Autophagy governs protumorigenic effects of mitotic slippage-induced senescence, Mol. Cancer Res, vol.16, pp.1625-1640, 2018. ,
Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence, Nat. Commun, vol.9, 1944. ,
Protein misfolding in the endoplasmic reticulum as a conduit to human disease, Nature, vol.529, pp.326-335, 2016. ,
ATF6? regulates morphological changes associated with senescence in human fibroblasts, Oncotarget, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01416106
Disseminated tumor cells persist in the bone marrow of breast cancer patients through sustained activation of the unfolded protein response, Cancer Res, vol.75, pp.5367-5377, 2015. ,
ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo, Proc. Natl. Acad. Sci. U.S.A, vol.105, pp.10519-10524, 2008. ,
Mechanisms of disseminated cancer cell dormancy: an awakening field, Nat. Rev. Cancer, vol.14, pp.611-622, 2014. ,
From ancient pathways to aging cells-connecting metabolism and cellular senescence, Cell Metabol, vol.23, pp.1013-1021, 2016. ,
p38MAPK is a novel DNA damage responseindependent regulator of the senescence-associated secretory phenotype, EMBO J, vol.30, pp.1536-1548, 2011. ,
Tumorigenic activity and therapeutic inhibition of Rheb GTPase, Genes Dev, vol.22, pp.2178-2188, 2008. ,
Cellular senescence as a tumor-suppressor mechanism, Trends Cell Biol, vol.11, pp.27-31, 2001. ,
Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes, Nature, vol.409, pp.633-637, 2001. ,
Senescence-associated oxidative DNA damage promotes the generation of neoplastic cells, Cancer Res, vol.69, pp.7917-7925, 2009. ,
Senescent fibroblasts enhance early skin carcinogenic events via a paracrine MMP-PAR-1 axis, PLoS One, vol.8, 2013. ,
Identification of a gene signature of a pre-transformation process by senescence evasion in normal human epidermal keratinocytes, Mol. Cancer, vol.13, p.151, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01011012
In vitro evidence for senescent multinucleated melanocytes as a source for tumorinitiating cells, Cell Death Dis, vol.6, p.1711, 2015. ,
Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing, Nat. Cell Biol, vol.18, pp.777-789, 2016. ,
Tumor cell escape from therapy-induced senescence, Biochem. Pharmacol, vol.162, pp.202-212, 2019. ,
Radiation-induced homotypic cell fusions of innately resistant glioblastoma cells mediate their sustained survival and recurrence, Carcinogenesis, vol.36, pp.685-695, 2015. ,
Evasion of a single-step, chemotherapy-induced senescence in breast cancer cells: implications for treatment response, Clin. Cancer Res, vol.11, pp.2637-2643, 2005. ,
Polyploidy formation in doxorubicin-treated cancer cells can favor escape from senescence, Neoplasia, vol.17, pp.882-893, 2015. ,
Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: implications for drug resistance and in vitro drug screening models, Cell Cycle, vol.8, pp.3208-3217, 2009. ,
, Cancer Letters, vol.463, pp.50-58, 2019.
Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy, Cell Biol. Int, vol.32, pp.1031-1043, 2008. ,
Senescence-associated reprogramming promotes cancer stemness, Nature, vol.553, pp.96-100, 2018. ,
Inactivation of p16 in human mammary epithelial cells by CpG island methylation, Mol. Cell. Biol, vol.18, pp.1793-1801, 1998. ,
Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation, Oncogene, vol.17, pp.199-205, 1998. ,
Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells, Cancer Res, vol.58, pp.3508-3512, 1998. ,
Stepwise DNA methylation changes are linked to escape from defined proliferation barriers and mammary epithelial cell immortalization, Cancer Res, vol.69, pp.5251-5258, 2009. ,
Targeting the senescence-overriding cooperative activity of structurally unrelated H3K9 demethylases in melanoma, Cancer Cell, vol.33, pp.322-336, 2018. ,
Regulation of senescence escape by the cdk4-EZH2-AP2M1 pathway in response to chemotherapy, Cell Death Dis, vol.9, 2018. ,
URL : https://hal.archives-ouvertes.fr/inserm-01718563
Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis, Oncotarget, vol.6, pp.43342-43362, 2015. ,
Polyploidy road to therapy-induced cellular senescence and escape, Int. J. Cancer, vol.132, pp.1505-1515, 2013. ,
Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis, Genes Dev, vol.26, pp.1055-1069, 2012. ,
Regulation of senescence escape by TSP1 and CD47 following chemotherapy treatment, Cell Death Dis, vol.10, 2019. ,
URL : https://hal.archives-ouvertes.fr/inserm-02055140
Spontaneous cell transformation: karyoplasts derived from multinucleated cells produce new cell growth in senescent human epithelial cell cultures, in Vitro Cell, Dev. Biol. Anim, vol.40, pp.150-158, 2004. ,
Polyploid tumour cells elicit paradiploid progeny through depolyploidizing divisions and regulated autophagic degradation, Cell Biol. Int, vol.35, pp.687-695, 2011. ,
MOS, aneuploidy and the ploidy cycle of cancer cells, Oncogene, vol.29, pp.5447-5451, 2010. ,
S6K1 is involved in polyploidization through its phosphorylation at Thr421/Ser424, J. Cell. Physiol, vol.219, pp.31-44, 2009. ,
Prevention of BMS-777607-induced polyploidy/senescence by mTOR inhibitor AZD8055 sensitizes breast cancer cells to cytotoxic chemotherapeutics, Mol Oncol, vol.8, pp.469-482, 2014. ,
Neosis: a novel type of cell division in cancer, Cancer Biol. Ther, vol.3, pp.207-218, 2004. ,
A complex secretory program orchestrated by the inflammasome controls paracrine senescence, Nat. Cell Biol, vol.15, pp.978-990, 2013. ,
Keeping the senescence secretome under control: molecular reins on the senescence-associated secretory phenotype, Exp. Gerontol, vol.82, pp.39-49, 2016. ,
The senescence-associated secretory phenotype: the dark side of tumor suppression, Annu. Rev. Pathol, vol.5, pp.99-118, 2010. ,
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging, Proc. Natl. Acad. Sci. U.S.A, vol.98, pp.12072-12077, 2001. ,
Attenuation of TGF-? signaling suppresses premature senescence in a p21-dependent manner and promotes oncogenic Ras-mediated metastatic transformation in human mammary epithelial cells, Mol. Biol. Cell, vol.23, pp.1569-1581, 2012. ,
The perivascular niche regulates breast tumour dormancy, Nat. Cell Biol, vol.15, pp.807-817, 2013. ,
The BCL-2 protein family, BH3-mimetics and cancer therapy, Cell Death Differ, vol.22, pp.1071-1080, 2015. ,
SCAMP4 enhances the senescent cell secretome, Genes Dev, vol.32, pp.909-914, 2018. ,
Identification of senescent cell surface targetable protein DPP4, Genes Dev, vol.31, pp.1529-1534, 2017. ,
, Cancer Letters, vol.463, pp.50-58, 2019.