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Connecting cancer relapse with senescence

Olivier Pluquet 1, * Corinne Abbadie 1 Olivier Coqueret 2 
* Corresponding author
2 CRCINA-ÉQUIPE 12 - Senescence Escape and Soluble Markers of Cancer Progression
CRCINA - Centre de Recherche en Cancérologie et Immunologie Nantes-Angers
Abstract : Many cancers respond to initial treatment but most of them relapse due to the persistence of dormant tumor cells. Determining the exact nature of the dormant state is crucial to develop therapies aiming to eradicate the dormant cells. Here, we argue that therapy-induced senescence of cancer cells could be an alternative form of dormancy.
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Submitted on : Monday, September 9, 2019 - 9:20:33 AM
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Olivier Pluquet, Corinne Abbadie, Olivier Coqueret. Connecting cancer relapse with senescence. Cancer Letters, Elsevier, 2019, 463, pp.50-58. ⟨10.1016/j.canlet.2019.08.004⟩. ⟨inserm-02281280⟩



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