Patients with ANCA-Associated Glomerulonephritis and Connective Tissue Diseases: A Comparative Study from the Maine-Anjou AAV Registry - Archive ouverte HAL Access content directly
Journal Articles Journal of Clinical Medicine Year : 2019

Patients with ANCA-Associated Glomerulonephritis and Connective Tissue Diseases: A Comparative Study from the Maine-Anjou AAV Registry

(1) , (1) , (1) , (2) , (3) , (4) , (1) , (1, 5) , (1) , (1) , (1, 3) , (3) , (2) , (6) , (6) , (5, 7) , (5, 1) , (5, 1)
1
2
3
4
5
6
7

Abstract

Background and objectives: The overlap between antineutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis (ANCA-GN) and connective tissue diseases (CTD) has been reported mainly as case series in the literature. Frequency of this association, as well as presentation and outcomes are unknown. Materials and Methods: Patients from the Maine-Anjou ANCA-associated vasculitides (AAV) registry with ANCA-GN diagnosed between 01/01/2000 and 01/01/2018, ANCA positivity, and at least six months of follow-up, were included. Results: 106 out of 142 patients fulfilled the inclusion criteria and were analyzed. CTD was present at ANCA-GN diagnosis in 16 (15.1%) patients. The most common CTD were rheumatoid arthritis, Sjogren syndrome and systemic sclerosis. Compared to the control group, females were more represented in the CTD group (75%, p = 0.001). Renal presentation was comparable between groups, including the pathological analysis of renal biopsies. Patients of CTD group presented a higher rate of non-renal relapse (25% versus 7.7%, p = 0.037), and experienced more frequently a venous thrombotic event (31.2% versus 10%, p = 0.021). No difference between groups was observed according to major outcomes. Conclusion: Association between CTD and ANCA-GN is not a rare condition and predominantly affects females. While AAV presentation is not significantly different, CTD patients experience more frequently non-renal relapse and venous thrombotic events.
Fichier principal
Vignette du fichier
Augusto2019Eq07.pdf (1.09 Mo) Télécharger le fichier
Origin : Publication funded by an institution
Loading...

Dates and versions

inserm-02281250 , version 1 (09-09-2019)

Identifiers

Cite

Fanny Guibert, Anne-Sophie Garnier, Samuel Wacrenier, Giorgina Piccoli, Assia Djema, et al.. Patients with ANCA-Associated Glomerulonephritis and Connective Tissue Diseases: A Comparative Study from the Maine-Anjou AAV Registry. Journal of Clinical Medicine, 2019, 8 (8), pii: E1218. ⟨10.3390/jcm8081218⟩. ⟨inserm-02281250⟩
58 View
61 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More