, WHO. World Malaria Report, 2018.
The pathogenic basis of malaria, Nature, vol.415, issue.6872, pp.673-679, 2002. ,
Malaria's deadly grip: cytoadhesion of Plasmodium falciparum-infected erythrocytes, Cell Microbiol, vol.15, issue.12, p.3836831, 2013. ,
Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes, Cell, vol.82, issue.1, pp.77-87, 1995. ,
Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes, Cell, vol.82, issue.1, pp.101-110, 1995. ,
, , p.3730239
The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes, Cell, vol.82, issue.1, pp.89-100, 1995. ,
Silence, activate, poise and switch! Mechanisms of antigenic variation in Plasmodium falciparum, Cell Microbiol, vol.15, issue.5, p.3654561, 2013. ,
Antigenic variation in malaria: in situ switching, relaxed and mutually exclusive transcription of var genes during intra-erythrocytic development in Plasmodium falciparum, EMBO J, vol.17, issue.18, p.1170867, 1998. ,
Plasmodium falciparum erythrocyte membrane protein 1 diversity in seven genomes-divide and conquer, PLoS Comput Biol, vol.6, issue.9, p.2940729, 2010. ,
Decoding the language of var genes and Plasmodium falciparum sequestration, Trends Parasitol, vol.17, issue.11, pp.538-545, 2001. ,
The cytoadherence ligand Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) binds to the P. falciparum knob-associated histidine-rich protein (KAHRP) by electrostatic interactions, Molecular and biochemical parasitology, vol.110, issue.2, pp.423-428, 2000. ,
Epidemiology and burden of malaria in pregnancy, Lancet Infect Dis, vol.7, issue.2, pp.93-104, 2007. ,
Malaria in pregnancy: small babies, big problem, Trends Parasitol, vol.27, issue.4, p.21377424, 2011. ,
Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta, Science, vol.272, issue.5267, pp.1502-1504, 1996. ,
Chondroitin-4-sulfate impairs in vitro and in vivo cytoadherence of Plasmodium falciparum infected erythrocytes, Mol Med, vol.3, issue.8, p.2230186, 1997. ,
Identification of multiple chondroitin sulfate A (CSA)-binding domains in the var2CSA gene transcribed in CSA-binding parasites, J Infect Dis, vol.191, issue.6, pp.1010-1013, 2005. ,
Evidence for the involvement of VAR2CSA in pregnancy-associated malaria, J Exp Med, vol.200, issue.9, p.2211857, 2004. ,
Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria, Mol Microbiol, vol.49, issue.1, pp.179-191, 2003. ,
A single member of the Plasmodium falciparum var multigene family determines cytoadhesion to the placental receptor chondroitin sulphate A, EMBO Rep, vol.6, issue.8, p.1369142, 2005. ,
Disruption of var2csa gene impairs placental malaria associated adhesion phenotype, PLoS ONE, vol.2, issue.9, p.1975670, 2007. ,
Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria, J Biol Chem, vol.287, issue.28, p.3390611, 2012. ,
Var2CSA minimal CSA binding region is located within the N-terminal region, PLoS ONE, vol.6, issue.5, p.3098292, 2011. ,
Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA, Proc Natl Acad Sci, vol.107, issue.11, p.2841952, 2010. ,
Ecto-phosphorylation of CD98 regulates cell-cell interactions, PLoS ONE, vol.3, issue.12, p.2587710, 2008. ,
Extracellular Protein Phosphorylation, the Neglected Side of the Modification, Molecular & cellular proteomics: MCP, vol.16, issue.1, p.5217775, 2016. ,
Ecto-protein kinases: ecto-domain phosphorylation as a novel target for pharmacological manipulation? Trends in pharmacological sciences, vol.20, pp.453-459, 1999. ,
RP1 is a phosphorylation target of CK2 and is involved in cell adhesion, PLoS ONE, vol.8, issue.7, p.3701075, 2013. ,
Erythrocytic casein kinase II regulates cytoadherence of Plasmodium falciparum-infected red blood cells, J Biol Chem, vol.284, issue.10, p.2649111, 2009. ,
Computational Fluid Dynamic Simulations of Maternal Circulation: Wall Shear Stress in the Human Placenta and Its Biological Implications, PLoS ONE, vol.11, issue.1, p.4729471, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01311196
Okadaic acid, useful tool for studying cellular processes, Curr Med Chem, vol.9, issue.2, pp.229-262, 2002. ,
Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system, Nature biotechnology, vol.32, issue.8, p.24880488, 2014. ,
Preclinical immunogenicity and safety of the cGMP-grade placental malaria vaccine PRIMVAC, EBioMedicine, vol.42, p.6491931, 2019. ,
Clinical development of placental malaria vaccines and immunoassays harmonization: a workshop report, Malar J, vol.15, p.5027113, 2016. ,
URL : https://hal.archives-ouvertes.fr/inserm-01367962
Antibody targeting of a specific region of Pfs47 blocks Plasmodium falciparum malaria transmission, NPJ Vaccines, vol.3, p.6039440, 2018. ,
Structure of the DBL3X-DBL4epsilon region of the VAR2CSA placental malaria vaccine candidate: insight into DBL domain interactions, Sci Rep, vol.5, p.4598876, 2015. ,
The phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii reveal unusual adaptations within and beyond the parasites' boundaries, Cell Host Microbe, vol.10, issue.4, p.3254672, 2011. ,
Six genes are preferentially transcribed by the circulating and sequestered forms of Plasmodium falciparum parasites that infect pregnant women, Infect Immun, vol.75, issue.10, p.2044550, 2007. ,
Mass spectrometric analysis of Plasmodium falciparum erythrocyte membrane protein-1 variants expressed by placental malaria parasites, Proteomics, vol.4, issue.4, p.15048989, 2004. ,
PfEMP1 expression is reduced on the surface of knobless Plasmodium falciparum infected erythrocytes, J Cell Sci, vol.118, p.15923663, 2005. ,
Global analysis of protein expression and phosphorylation of three stages of Plasmodium falciparum intraerythrocytic development, J Proteome Res, vol.12, issue.9, p.5292867, 2013. ,
The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner, Nat Commun, vol.9, issue.1, p.6095877, 2018. ,
Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein, Epub 2015/ 10/16, vol.28, p.4790448, 2015. ,
SAM domain-dependent activity of PfTKL3, an essential tyrosine kinase-like kinase of the human malaria parasite Plasmodium falciparum. Cellular and molecular life sciences: CMLS, vol.67, p.2933843, 2010. ,
A secreted Plasmodium falciparum kinase reveals a signature motif for classification of tyrosine kinase-like kinases, Microbiology, vol.159, p.24045796, 2013. ,
Malaria Parasite-Infected Erythrocytes Secrete PfCK1, the Plasmodium Homologue of the Pleiotropic Protein Kinase Casein Kinase 1, PLoS ONE, vol.10, issue.12, p.4668060, 2015. ,
A novel protein kinase family in Plasmodium falciparum is differentially transcribed and secreted to various cellular compartments of the host cell, Mol Microbiol, vol.63, issue.2, p.17181785, 2007. ,
An exported kinase (FIKK4.2) that mediates virulence-associated changes in Plasmodium falciparum-infected red blood cells, Int J Parasitol, vol.44, issue.5, p.24530877, 2014. ,
Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence, Proteomics, vol.4, issue.6, p.15174133, 2004. ,
Functional analysis of protein kinase CK2 of the human malaria parasite Plasmodium falciparum, Eukaryotic cell, vol.8, issue.3, p.2653243, 2008. ,
URL : https://hal.archives-ouvertes.fr/inserm-00413565
Plasmodium falciparum Adhesins Play an Essential Role in Signalling and Activation of Invasion into Human Erythrocytes, PLoS Pathog, vol.11, issue.12, p.4687929, 2015. ,
Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assembly pathway, BMC Biol, vol.10, p.3296614, 2012. ,
URL : https://hal.archives-ouvertes.fr/inserm-00677275
Human malaria parasites in continuous culture, Science, vol.193, issue.4254, pp.673-675, 1976. ,
An alternative method for Plasmodium culture synchronization, Exp Parasitol, vol.109, issue.3, p.15713452, 2005. ,
Baculovirus expression, purification, and characterization of human protein phosphatase 2A catalytic subunits alpha and beta. Protein expression and purification, vol.45, p.16039140, 2006. ,
The human placental derived BeWo cell line: a useful model for selecting Plasmodium falciparum CSA-binding parasites, Exp Parasitol, vol.112, issue.2, p.16274691, 2006. ,
Antibodies to a fulllength VAR2CSA immunogen are broadly strain-transcendent but do not cross-inhibit different placental-type parasite isolates, PLoS ONE, vol.6, issue.2, p.3034725, 2011. ,
The use of titanium dioxide micro-columns to selectively isolate phosphopeptides from proteolytic digests, Methods in molecular biology, vol.527, pp.57-66, 2009. ,
Universal and confident phosphorylation site localization using phosphoRS, J Proteome Res, vol.10, issue.12, pp.5354-5362, 2011. ,
The Phyre2 web portal for protein modeling, prediction and analysis, Nat Protoc, vol.10, issue.6, p.5298202, 2015. ,