P. A. Aas, M. Otterlei, P. O. Falnes, C. B. Vagbe, F. Skorpen et al., Human and bacterial oxidative demethylase repair alkylation damage in both RNA and DNA, Nature, vol.421, pp.859-862, 2003.

T. Akaike, Role of free radical in viral pathogenesis and mutation, Rev. Med. Virol, vol.11, pp.87-101, 2001.

O. Ben-zaken, S. Tzaban, Y. Tal, .. L. Horonchik, J. D. Esko et al., Cellular heparan sulfate participates in the metabolism of prions, J. Biol. Chem, vol.278, pp.40041-40049, 2003.

S. Burney, J. L. Caulfield, J. C. Niles, J. S. Wishnok, and S. R. Tannenbaum, The chemistry of DNA damage from nitric oxide and peroxynitrite, Mutat. Res, vol.424, pp.37-49, 1999.

J. Cadet, T. Delatour, T. Douki, D. Gasparutto, J. P. Pouget et al., Hydroxyl radicals and DNA base damage, Mutat. Res, vol.424, pp.9-21, 1999.

S. Capellari, S. I. Zaidi, C. B. Urig, G. Perry, M. A. Smith et al., Prion protein glycosylation is sensitive to redox change, J. Biol. Chem, vol.274, pp.34846-34850, 1999.

M. R. Culbertson, RNA surveillance: unforseen consequences for gene expression, inhirited genetic disorders and cancer, Trends Genet, vol.15, pp.74-80, 1999.

S. K. Debburman, G. J. Raymond, B. Caughey, and S. Lindquist, Chaperone-supervised conversion of prion protein to its proteaseresistant form, Proc. Natl Acad. Sci, vol.94, pp.13938-13943, 1997.

N. R. Deleault, R. W. Lucassen, and S. Supattapone, RNA molecules stimulate prion protein conversion, Nature, vol.425, pp.717-720, 2003.

B. K. Duncan and J. H. Miller, Mutagenic deamination of cytosine residues in DNA, Nature, vol.287, pp.560-561, 1980.

S. R. Eddy, Non-coding RNA genes and the modern RNA world, Nat. Rev. Genet, vol.2, pp.919-929, 2001.

E. S. Fiala, C. C. Conaway, and J. E. Mathis, Oxidative DNA and RNA damage in the livers of Sprague-Dawley rats treated with the hepatocarcinogen 2-nitropropane, Cancer Res, vol.49, pp.5518-5522, 1989.

L. A. Frederico, T. A. Kunkel, and B. R. Shaw, A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energy, Biochemistry, vol.29, pp.2532-2537, 1990.

P. H. Frederikse, S. J. Zigler, P. N. Farnsworth, and D. A. Carper, Prion protein expression in mammalian lenses, Curr. Eye Res, vol.20, pp.137-143, 2000.

M. Glatzel and A. Aguzzi, The shifting biology of prion, Brain Res. Rev, vol.36, pp.241-248, 2001.

J. M. Gott and R. B. Emeson, Function and mechanisms of RNA editing, Annu. Rev. Genet, vol.34, pp.499-531, 2000.

J. S. Griffith, Self replication and scrapie, Nature, vol.215, pp.1043-1044, 1967.

B. Halliwell, Oxygen and nitrogen are pro-carcinogens. Damage to DNA by reactive oxygen, chlorine and nitrogen species: measurement, mechanism and the effects of nutrition, Mutat. Res, vol.443, pp.37-52, 1999.

H. Hayakawa, M. Kuwano, and M. Sekiguchi, Specific binding of 8-oxoguanine-containing RNA to polynucleotide phosphorylase protein, Biochemistry, vol.40, pp.9977-9982, 2001.

F. W. Leeuwen, P. H. Burbach, and E. M. Hol, Mutations in RNA: a first example of molecular misreading in alzheimer's disease, Trends Neurosci, vol.21, pp.331-335, 1998.

H. Maki and M. Sekiguchi, MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis, Nature, vol.355, pp.273-275, 1992.

E. Mckintosh, S. J. Tabrizi, and J. Collinge, Prion diseases, J. Neurovirol, vol.9, pp.183-193, 2003.

J. Y. Mo, H. Maki, and M. Sekiguchi, Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: sanitization of nucleotide pool, Proc. Natl Acad. Sci, vol.89, pp.11021-11025, 1992.

T. Nguyen, D. Brunson, C. L. Crespi, B. W. Penman, J. S. Wishnok et al., DNA damage and mutation in human cells exposed to nitric oxide in vitro, Proc. Natl Acad. Sci, vol.89, pp.3030-3034, 1992.

A. Nunomura, G. Perry, M. A. Pappolla, R. Wade, K. Hirai et al., RNA oxidation is a pominent feature of vulnerable neurons in Alzheimer's disease, J. Neurosci, vol.19, pp.1959-1964, 1999.

K. J. O'byrne and A. G. Dalgleish, Chronic immune activation and inflammation as the cause of malignancy, Br. J. Cancer, vol.85, pp.473-483, 2001.

K. M. Pan, M. Baldwin, J. Nguyen, M. Gasset, .. A. Serban et al., Conversion of a-helices into b-sheets features in the formation of the scrapie prion proteins, Proc. Natl Acad. Sci. USA, vol.90, pp.10962-10966, 1993.

K. Pfeifer, M. Bachmann, H. C. Schroder, J. Forrest, and W. E. Muller, Kinetics of expression of prion protein in uninfected and scrapie-infected N2a mouse neuroblastoma cells, Cell Biochem. Funct, vol.11, pp.1-11, 1993.

S. B. Prusiner, Prions. Proc. Natl Acad. Sci, vol.95, pp.13363-13383, 1998.

H. Reiersen and R. A. Rees, The hunchback and its neighbours: proline as an environmental modulator, Trends Biochem. Sci, vol.26, pp.679-684, 2001.

Z. Shen, W. Wu, and S. L. Hazen, Activated leukocytes oxidatively damage DNA, RNA and the nucleotide pool through halidedependent formation of hydroxyl radical, Biochemistry, vol.39, pp.5474-5482, 2000.

N. Stahl, M. A. Baldwin, D. B. Teplow, L. Hood, B. W. Gibson et al., Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing, Biochemistry, vol.32, 1991.

W. G. Wamer and R. R. Wei, In vitro photooxidation of nucleic acids by ultraviolet A radiation, Photochem. Photobiol, vol.65, pp.560-563, 1997.

S. J. Wood, R. Wetzel, J. D. Martin, and M. R. Hurle, Prolines and amyloidogenicity in fragments of Alzheimer's peptide beta/A4, Biochemistry, vol.34, pp.724-730, 1995.

J. Zhang, G. Perry, M. A. Smith, D. Robertson, S. J. Olson et al., Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons, Am. J. Pathol, vol.154, pp.1423-1429, 1999.