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FLT3 ligand plasma levels have no impact on outcomes after allotransplant in acute leukemia

Abstract : Objective: This study was designed to assess the impact on outcomes of early soluble Fms-like tyrosine kinase 3 ligand concentrations (sFLc) in patients receiving an allogeneic hematopoietic stem cell transplantation (allo-HSCT) for acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Methods: This was a prospective monocentric study including all allo-HSCT patients included in the previous FLAM/FLAL study (Peterlin et al., 2019). Blood samples collected before the start of conditioning then post-transplant were frozen, stored and tested by ELISA. The parameters considered were hematopoietic recoveries, Leukemia Free Survival and Overall Survival, acute and chronic GVHD, grade 3 or 4 acute and/or extensive chronic GVHD-free and relapse-free survival (GRFS). Results: Forty-one patients were included, a total of 179 samples were assayed for sFLc. There was no impact of sFLc levels (< =median vs > median) on acute and chronic GVHD incidences, LFS, OS nor GRFS. Conclusion: At variance with induction results for AML (Peterlin et al., 2019) endogenous sFLc do not appear to be a prognostic marker at the time of or after allo-HSCT. Even though the results are negatives, this is, to the best of our knowledge, the only prospective series specifically addressing the question of sFLc impact after allo-HSCT in acute leukemias.
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Submitted on : Wednesday, August 14, 2019 - 9:24:52 AM
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Pierre Peterlin, Joëlle Gaschet, Thierry Guillaume, Alice Garnier, Marion Eveillard, et al.. FLT3 ligand plasma levels have no impact on outcomes after allotransplant in acute leukemia. Cytokine, Elsevier, 2019, 120, pp.85-87. ⟨10.1016/j.cyto.2019.04.015⟩. ⟨inserm-02266372⟩



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