Multiple myeloma: Evolving genetic events and host interactions, Nat. Rev. Cancer, vol.2, pp.175-187, 2002. ,
Cancer statistics, CA Cancer J. Clin, vol.65, pp.5-29, 2015. ,
The unfolded protein response: From stress pathway to homeostatic regulation, Science, vol.334, pp.1081-1086, 2011. ,
The unfolded protein response: Controlling cell fate decisions under ER stress and beyond, Nat. Rev. Mol. Cell Biol, vol.13, pp.89-102, 2012. ,
Protein misfolding in the endoplasmic reticulum as a conduit to human disease, Nature, vol.529, pp.326-335, 2016. ,
Tumorigenic and immunosuppressive effects of endoplasmic reticulum stress in cancer, Cell, vol.168, pp.692-706, 2017. ,
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress, Nat. Cell Biol, vol.13, pp.184-190, 2011. ,
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase, Cell, vol.73, pp.1197-1206, 1993. ,
Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing, Cell, vol.132, pp.89-100, 2008. ,
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/ endoribonuclease (Ire1p) in mammalian cells, Genes Dev, vol.12, pp.1812-1824, 1998. ,
The unfolded protein response signals through high-order assembly of Ire1, Nature, vol.457, pp.687-693, 2009. ,
IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates, Cell, vol.138, pp.562-575, 2009. ,
A synthetic biology approach identifies the mammalian UPR RNA ligase RtcB, Mol. Cell, vol.55, pp.758-770, 2014. ,
Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation, Cell, vol.101, pp.249-258, 2000. ,
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation, Immunity, vol.21, pp.81-93, 2004. ,
XBP1 controls diverse cell type-and condition-specific transcriptional regulatory networks, Mol. Cell, vol.27, pp.53-66, 2007. ,
Cleaning up: ER-associated degradation to the rescue, Cell, vol.151, pp.1163-1167, 2012. ,
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response, Science, vol.313, pp.104-107, 2006. ,
Regulated Ire1-dependent decay of messenger RNAs in mammalian cells, J. Cell Biol, vol.186, pp.323-331, 2009. ,
Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis, Science, vol.345, pp.98-101, 2014. ,
Coordination between two branches of the unfolded protein response determines apoptotic cell fate, Mol. Cell, vol.71, pp.629-636, 2018. ,
Plasma cell differentiation requires the transcription factor XBP-1, Nature, vol.412, pp.300-307, 2001. ,
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1, Nat. Immunol, vol.4, pp.321-329, 2003. ,
The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis, J. Clin. Invest, vol.115, pp.268-281, 2005. ,
Hallmarks of cancer: The next generation, Cell, vol.144, pp.646-674, 2011. ,
Endoplasmic reticulum stress and the unfolded protein response: Targeting the achilles heel of multiple myeloma, Mol. Cancer Ther, vol.12, pp.831-843, 2013. ,
The impact of the endoplasmic reticulum protein-folding environment on cancer development, Nat. Rev. Cancer, vol.14, pp.581-597, 2014. ,
Targeting the IRE1?-XBP1 branch of the unfolded protein response in human diseases, Semin. Cancer Biol, vol.33, pp.48-56, 2015. ,
The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis, Cancer Cell, vol.11, pp.349-360, 2007. ,
XBP1s levels are implicated in the biology and outcome of myeloma mediating different clinical outcomes to thalidomide-based treatments, Blood, vol.116, pp.250-253, 2010. ,
Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma, Blood, vol.117, pp.1311-1314, 2011. ,
Blockade of XBP1 splicing by inhibition of IRE1? is a promising therapeutic option in multiple myeloma, Blood, vol.119, pp.5772-5781, 2012. ,
Multiple myeloma, Nat. Rev. Dis. Primers, vol.3, p.17046, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01813384
Response of myeloma to the proteasome inhibitor bortezomib is correlated with the unfolded protein response regulator XBP-1, Haematologica, vol.97, pp.64-72, 2012. ,
Unfolded protein response in cancer: IRE1? inhibition by selective kinase ligands does not impair tumor cell viability, ACS Med. Chem. Lett, vol.6, pp.68-72, 2014. ,
The inositol-requiring enzyme 1 (IRE1?) RNAse inhibitor, 4?8C, is also a potent cellular antioxidant, Biochem. J, vol.475, pp.923-929, 2018. ,
ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells, J. Exp. Med, vol.210, pp.2041-2056, 2013. ,
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1, Science, vol.287, pp.664-666, 2000. ,
Molecular characterization of human multiple myeloma cell lines by integrative genomics: Insights into the biology of the disease, Genes Chromosomes Cancer, vol.46, pp.226-238, 2007. ,
A VEGF-dependent autocrine loop mediates proliferation and capillarogenesis in bone marrow endothelial cells of patients with multiple myeloma, Thromb. Haemost, vol.92, pp.1438-1445, 2004. ,
XBP1 promotes triple-negative breast cancer by controlling the HIF1? pathway, Nature, vol.508, pp.103-107, 2014. ,
Allosteric inhibition of the IRE1? RNase preserves cell viability and function during endoplasmic reticulum stress, Cell, vol.158, pp.534-548, 2014. ,
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule, Proc. Natl. Acad. Sci. U.S.A, vol.109, pp.869-878, 2012. ,
A bioluminescence imaging based in vivo model for preclinical testing of novel cellular immunotherapy strategies to improve the graft-versusmyeloma effect, Haematologica, vol.93, pp.1049-1057, 2008. ,
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability, Proc. Natl. Acad. Sci. U.S.A, vol.106, pp.16657-16662, 2009. ,
IRE1? disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level, PLoS One, vol.5, p.13052, 2010. ,
Hepatic IRE1? regulates fasting-induced metabolic adaptive programs through the XBP1s-PPAR? axis signalling, Nat. Commun, vol.5, p.3528, 2014. ,
Improved physiological properties of gravity-enforced reassembled rat and human pancreatic pseudo-islets, J. Tissue Eng. Regen. Med, vol.11, pp.109-120, 2017. ,
Xbp1s-negative tumor B cells and pre-plasmablasts mediate therapeutic proteasome inhibitor resistance in multiple myeloma, Cancer Cell, vol.24, pp.289-304, 2013. ,
The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins, Science, vol.343, pp.305-309, 2014. ,
Cell death via DR5, but not DR4, is regulated by p53 in myeloma cells, Cancer Res, vol.72, pp.4562-4573, 2012. ,