Glioblastoma Stem-Like Cells, Metabolic Strategy to Kill a Challenging Target

Delphine Garnier; Ophélie Renoult; Marie-Clotilde Alves-Guerra; François Paris; Claire Pecqueur

Glioblastoma Stem-Like Cells, Metabolic Strategy to Kill a Challenging Target

Delphine Garnier ¹ Ophélie Renoult ² Marie-Clotilde Alves-Guerra ^{3, 4} François Paris ^{2, 5} Claire Pecqueur ^{2, 6, *}

* Corresponding author

1 CRCINA - Département ONCO - Equipe 9 - Apoptosis and tumor progression -ATP

CRCINA - Centre de recherche de Cancérologie et d'Immunologie / Nantes - Angers

2 CRCINA - Département ONCO - Equipe 14 - Endothelium radiobiology and targeting

CRCINA - Centre de recherche de Cancérologie et d'Immunologie / Nantes - Angers

3 IC UM3 (UMR 8104 / U1016) - Institut Cochin

4 USPC - Université Sorbonne Paris Cité

5 ICO Nantes - Institut de cancérologie de l'Ouest - Nantes

6 LabEx IGO “Immunotherapy, Graft, Oncology” [Nantes]

Abstract : Over the years, substantial evidence has definitively confirmed the existence of cancer stem-like cells within tumors such as Glioblastoma (GBM). The importance of Glioblastoma stem-like cells (GSCs) in tumor progression and relapse clearly highlights that cancer eradication requires killing of GSCs that are intrinsically resistant to conventional therapies as well as eradication of the non-GSCs cells since GSCs emergence relies on a dynamic process. The past decade of research highlights that metabolism is a significant player in tumor progression and actually might orchestrate it. The growing interest in cancer metabolism reprogrammation can lead to innovative approaches exploiting metabolic vulnerabilities of cancer cells. These approaches are challenging since they require overcoming the compensatory and adaptive responses of GSCs. In this review, we will summarize the current knowledge on GSCs with a particular focus on their metabolic complexity. We will also discuss potential approaches targeting GSCs metabolism to potentially improve clinical care.

Keywords : cancer plasticity Glioblastoma cancer stem cells cancer metabolism tumor microenvironment cancer heterogeneity

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Cancer

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https://www.hal.inserm.fr/inserm-02240417
Contributor : Elizabeth Bernardo <>
Submitted on : Thursday, August 1, 2019 - 4:03:06 PM
Last modification on : Sunday, August 4, 2019 - 1:09:53 AM

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