Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study, Lancet, vol.384, issue.9945, p.4624264, 2013. ,
Finding the missing heritability in pediatric obesity: the contribution of genome-wide complex trait analysis, Int J Obes (Lond), vol.37, issue.11, p.3826033, 2013. ,
Diabetes risk among overweight and obese metabolically healthy young adults, Diabetes Care, vol.37, issue.11, p.25139886, 2014. ,
Inactivation of Pif1 helicase causes a mitochondrial myopathy in mice, Mitochondrion, vol.30, p.26923168, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-02108743
Human PIF helicase is cell cycle regulated and associates with telomerase, Cell cycle (Georgetown, Tex), vol.5, p.17172855, 2006. ,
Alternative translation initiation augments the human mitochondrial proteome, Nucleic Acids Research, vol.41, pp.2354-69, 2013. ,
The saccharomyces PIF1 DNA helicase inhibits telomere elongation and de novo telomere formation, Cell, vol.76, p.8287473, 1994. ,
Repair of chromosome ends after telomere loss in Saccharomyces, Mol Biol Cell, vol.12, issue.12, p.60777, 2001. ,
Roles of Pif1-like helicases in the maintenance of genomic stability, Nucleic Acids Res, vol.34, issue.15, pp.4147-53, 2006. ,
, , p.1616966
Sensitivity of yeast strains with long G-tails to levels of telomere-bound telomerase, PLoS Genetics, vol.3, p.17590086, 2007. ,
Pif1 family helicases suppress genome instability at G-quadruplex motifs, Nature, vol.497, p.23657261, 2013. ,
DNA replication: Pif1 overcomes a quadruplex hurdle, Nature Reviews Molecular Cell Biology, vol.12, pp.402-405, 2011. ,
Murine Pif1 interacts with telomerase and is dispensable for telomere function in vivo, Molecular and Cellular Biology, vol.27, p.17130244, 2007. ,
Two-dimensional intact mitochondrial DNA agarose electrophoresis reveals the structural complexity of the mammalian mitochondrial genome, Nucleic Acids Research, vol.41, p.58, 2013. ,
Analysis of relative gene expression data using real-time quantitative PCR and, Methods, vol.25, p.11846609, 2001. ,
Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer, J Exp Med, vol.204, issue.9, p.2118713, 2007. ,
Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice, Free Radical Biology and Medicine, vol.75, p.25106705, 2014. ,
, Assessment of feeding behavior in laboratory mice, 2010.
Energy metabolism in the liver, Compr Physiol, vol.4, issue.1, p.4050641, 2014. ,
Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass, J Biol Chem, vol.278, issue.36, p.12805374, 2003. ,
Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice, Biochem Biophys Res Commun, vol.336, issue.1, p.16125673, 2005. ,
Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes, J Clin Invest, vol.111, issue.5, pp.737-784, 2003. ,
, , p.151902
Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27, Cell Metab, vol.7, issue.4, p.2587176, 2008. ,
Role for PPARgamma in obesity-induced hepatic steatosis as determined by hepatocyte-and macrophage-specific conditional knockouts, FASEB J, vol.25, issue.8, p.21507897, 2011. ,
Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia, Proc Natl Acad Sci U S A, vol.102, issue.11, p.15738389, 2005. ,
, , p.554825
Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance, J Biol Chem, vol.281, issue.36, p.16809344, 2006. ,
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity, J Clin Invest, vol.116, issue.6, pp.1494-505, 2006. ,
, , p.1459069
Adipocytes as regulators of energy balance and glucose homeostasis, Nature, vol.444, issue.7121, p.3212857, 2006. ,
Monocyte chemoattractant protein 1 in obesity and insulin resistance, Proc Natl Acad Sci U S A, vol.100, issue.12, p.165864, 2003. ,
High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice, Aging (Albany NY), vol.7, issue.4, p.25979814, 2015. ,
, , p.4429090
C57BL/6J and A/J mice fed a high-fat diet delineate components of metabolic syndrome. Obesity (Silver Spring), vol.15, p.17712117, 2007. ,
Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice, Obesity (Silver Spring), vol.18, issue.3, pp.463-472, 2010. ,
Female mice are protected against high-fat diet induced metabolic syndrome and increase the regulatory T cell population in adipose tissue, PLoS One, vol.7, issue.9, p.3458106, 2012. ,
Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications, Lancet Diabetes Endocrinol, vol.1, issue.2, pp.152-62, 2013. ,
Metabolically healthy obesity: definitions, determinants and clinical implications, Rev Endocr Metab Disord, vol.14, issue.3, p.23928851, 2013. ,
Mechanisms for insulin resistance: common threads and missing links, Cell, vol.148, issue.5, p.22385956, 2012. ,
, , p.3294420
The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux, J Clin Invest, vol.126, issue.1, p.4701542, 2016. ,
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease, J Biol Chem, vol.279, issue.31, p.15166226, 2004. ,
Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice. Proceedings of the National Academy of Sciences of the United States of America, vol.102, p.16301523, 2005. ,
The clinical, histochemical, and molecular spectrum of PEO1 (Twinkle)-linked adPEO, Epub 2010/ 05/19, vol.74, p.2875130, 2010. ,
Toward a more complete (and less controversial) understanding of energy expenditure and its role in obesity pathogenesis, Diabetes, vol.60, issue.1, p.3012169, 2011. ,