Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

Abstract : In T-cell precursors, the T-cell-receptor beta chain is expressed before the T-cell-receptor alpha chain and is sufficient to advance T-cell development in the absence of T-cell receptor alpha chains. In immature T cells, the T-cell-receptor beta protein can form disulphide-linked heterodimers with the pre-T-cell-receptor alpha chain and associate with signal-transducing CD3 molecules. The recently cloned pre-T-cell-receptor alpha gene encodes a transmembrane protein that is expressed in immature but not mature T cells. Here we show that alpha beta, but not gamma delta, cell development is severely hampered in pre-T-cell-receptor alpha-gene-deficient mice, which establishes a crucial role for the pre-T-cell receptor in early thymocyte development.
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Hans Jörg Fehling, Anna Krotkova, Claude Saint-Ruf, Harald von Boehmer. Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells. Nature, Nature Publishing Group, 1995, 375 (6534), pp.795-798. ⟨10.1038/375795a0⟩. ⟨inserm-02179382⟩

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