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Journal articles
Analysis and expression of a cloned pre-T cell receptor gene
Abstract : The T cell antigen receptor (TCR) beta chain regulates early T cell development in the absence of the TCR alpha chain. The developmentally controlled gene described here encodes the pre-TCR alpha (pT alpha) chain, which covalently associates with TCR beta and with the CD3 proteins forms a pre-TCR complex that transduces signals in immature thymocytes. Unlike the lambda 5 pre-B cell receptor protein, the pT alpha chain is a type I transmembrane protein whose cytoplasmic tail contains two potential phosphorylation sites and a Src homology 3 (SH3)-domain binding sequence. Pre-TCR alpha transfection experiments indicated that surface expression of the pre-TCR is controlled by additional developmentally regulated proteins. Identification of the pT alpha gene represents an essential step in the structure-function analysis of the pre-TCR complex.
Cited literature [43 references]
https://www.hal.inserm.fr/inserm-02177273
Contributor : Claude Saint-Ruf Connect in order to contact the contributor
Submitted on : Monday, July 8, 2019 - 5:47:50 PM
Last modification on : Thursday, May 27, 2021 - 5:08:03 PM
Contributor : Claude Saint-Ruf Connect in order to contact the contributor
Submitted on : Monday, July 8, 2019 - 5:47:50 PM
Last modification on : Thursday, May 27, 2021 - 5:08:03 PM