Clinical recognition of meningococcal disease in children and adolescents, Lancet Lond Engl, vol.367, pp.67932-67936, 2006. ,
Proposed classification and pathologic mechanisms of purpura fulminans and skin necrosis, Semin Thromb Hemost, vol.16, p.2281322, 1990. ,
Skin Manifestations of Meningococcal Infection, vol.17, pp.55-56, 2011. ,
Epidemic meningococcemia and purpura fulminans with induced protein C deficiency, Clin Infect Dis Off Publ Infect Dis Soc Am, vol.17, pp.254-261, 1993. ,
The Waterhouse-Friderichsen Syndrome, N Engl J Med, vol.232, pp.1-7, 1945. ,
Rupert waterhouse and carl friderichsen: adrenal apoplexy, J Emerg Med, vol.16, p.9696186, 1998. ,
Pathogenesis and Diagnosis of Human Meningococcal Disease Using Immunohistochemical and PCR Assays, Am J Clin Pathol, vol.122, p.15491972, 2004. ,
Long-term skin scarring and orthopaedic sequelae in survivors of meningococcal septic shock, Arch Dis Child, vol.94, p.19147623, 2009. ,
Outcomes of invasive meningococcal disease in adults and children in Canada between 2002 and 2011: a prospective cohort study, Clin Infect Dis Off Publ Infect Dis Soc Am, vol.60, p.25605282, 2015. ,
The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex, Proc Natl Acad Sci U S A, vol.93, p.8816778, 1996. ,
The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis, Blood, vol.95, p.10688824, 2000. ,
Endothelial cell protein C receptor plays an important role in protein C activation in vivo, Blood, vol.97, p.11238108, 2001. ,
Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxin, J Thromb Haemost JTH, vol.3, p.15978090, 2005. ,
Characterization of mice harboring a variant of EPCR with impaired ability to bind protein C: novel role of EPCR in hematopoiesis, Blood, vol.126, p.26045607, 2015. ,
Dysfunction of endothelial protein C activation in severe meningococcal sepsis, N Engl J Med, vol.345, p.11496851, 2001. ,
Pathogenesis of cutaneous lesions in acute meningococcemia in humans: light, immunofluorescent, and electron microscopic studies of skin biopsy specimens, J Infect Dis, vol.133, p.816975, 1976. ,
Analysis of pathogenhost cell interactions in purpura fulminans: expression of capsule, type IV pili, and PorA by Neisseria meningitidis in vivo, Infect Immun, vol.70, p.12183570, 2002. ,
Cerebral microcirculation shear stress levels determine Neisseria meningitidis attachment sites along the blood-brain barrier, J Exp Med, vol.203, p.16864659, 2006. ,
Chronic Meningococcemia Cutaneous Lesions Involve Meningococcal Perivascular Invasion Through the Remodeling of Endothelial Barriers, Clin Infect Dis, vol.54, p.22412064, 2012. ,
URL : https://hal.archives-ouvertes.fr/pasteur-02085535
Acute bacterial septic vasculopathy, Int J Dermatol, vol.52, p.23231414, 2013. ,
Pathogenic Neisseria meningitidis utilizes CD147 for vascular colonization, Nat Med, vol.20, p.24880614, 2014. ,
Exceptionally widespread nanomachines composed of type IV pilins: the prokaryotic Swiss Army knives, FEMS Microbiol Rev, vol.39, p.25793961, 2015. ,
Meningococcal type IV pili recruit the polarity complex to cross the brain endothelium, Science, vol.325, p.19520910, 2009. ,
Meningococcus Hijacks a beta2-adrenoceptor/beta-Arrestin pathway to cross brain microvasculature endothelium, Cell, vol.143, p.21183077, 2010. ,
Two strikingly different signaling pathways are induced by meningococcal type IV pili on endothelial and epithelial cells, Infect Immun, vol.80, p.22064711, 2012. ,
Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor-alpha converting enzyme/ADAM17, J Thromb Haemost JTH, vol.5, p.17155946, 2007. ,
The ADAM metalloproteinases, Mol Aspects Med, vol.29, p.18762209, 2008. ,
ADAM15 gene structure and differential alternative exon use in human tissues, BMC Mol Biol, vol.8, p.17937806, 2007. ,
ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as transforming growth factor alpha, L-selectin, and tumor necrosis factor alpha, Mol Biol Cell, vol.20, p.19158376, 2009. ,
Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules, Comb Chem High Throughput Screen, vol.8, p.15777180, 2005. ,
Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis, J Biol Chem, vol.276, p.11278252, 2001. ,
Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor, Biochem J, vol.373, p.12683950, 2003. ,
Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective, Nat Med, vol.9, p.12563316, 2003. ,
Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46, Blood, vol.120, p.23149848, 2012. ,
Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway, J Thromb Haemost JTH, vol.11, issue.1, p.23809128, 2013. ,
Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation, Blood, vol.105, p.15626732, 2005. ,
Activated Protein C Mediates Novel Lung Endothelial Barrier Enhancement: ROLE OF SPHINGOSINE 1-PHOSPHATE RECEPTOR TRANSACTIVATION, J Biol Chem, vol.280, p.15710622, 2005. ,
Cytoprotective-Selective Activated Protein C Attenuates Pseudomonas aeruginosa-Induced Lung Injury in Mice, Am J Respir Cell Mol Biol, vol.45, p.21257925, 2011. ,
Assessment of the interplay between blood and skin vascular abnormalities in adult purpura fulminans, Am J Respir Crit Care Med, vol.188, p.23924269, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-01389220
Extraembryonic expression of EPCR is essential for embryonic viability, Blood, vol.106, p.15956290, 2005. ,
Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor, Arterioscler Thromb Vasc Biol, vol.33, p.23393392, 2013. ,
Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx ,
, Mol Biol Cell, vol.18, p.17079736, 2007.
ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin, Circ Res, vol.102, p.18420943, 2008. ,
Role of ADAMs in endothelial cell permeability: cadherin shedding and leukocyte rolling, Circ Res, vol.102, p.18497310, 2008. ,
Soluble VE-cadherin is involved in endothelial barrier breakdown in systemic inflammation and sepsis, Cardiovasc Res, vol.107, p.25975259, 2015. ,
A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice, Nat Med, vol.17, p.21926978, 2011. ,
ADAM10 mediates vascular injury induced by Staphylococcus aureus ?-hemolysin, J Infect Dis, vol.206, p.22474035, 2012. ,
The metalloproteinase ADAM10: A useful therapeutic target?, Biochim Biophys Acta BBA-Mol Cell Res, vol.1864, p.28624438, 2017. ,
Structural Basis for Regulated Proteolysis by the ?-Secretase ADAM10, Cell, vol.171, p.29224781, 2017. ,
The protein C pathway and sepsis, Thromb Res, vol.129, p.22154246, 2012. ,
Efficacy and safety of recombinant human activated protein C for severe sepsis, N Engl J Med, vol.344, p.11236773, 2001. ,
Drotrecogin alfa (activated) in adults with septic shock, N Engl J Med, vol.366, p.22616830, 2012. ,
URL : https://hal.archives-ouvertes.fr/inserm-00865183
The aPC treatment improves microcirculation in severe sepsis/septic shock syndrome, BMC Anesthesiol, vol.13, p.24070065, 2013. ,
Effectiveness and safety of drotrecogin alfa (activated) for severe sepsis: a metaanalysis and metaregression, Lancet Infect Dis, vol.12, issue.12, p.22809883, 2012. ,
Drotrecogin alfa (activated) in severe sepsis, Lancet Infect Dis, vol.13, p.23347627, 2013. ,
Treatment of purpura fulminans in meningococcemia with protein C concentrate, J Pediatr, vol.126, p.7699550, 1995. ,
Use of protein-C concentrate, heparin, and haemodiafiltration in meningococcus-induced purpura fulminans, Lancet Lond Engl, vol.350, pp.1590-1593, 1997. ,
Protein C in the treatment of coagulopathy in meningococcal disease, Crit Care Med, vol.26, p.9590329, 1998. ,
Protein-C concentrate for meningococcal purpura fulminans, Lancet Lond Engl, vol.351, pp.986-987, 1998. ,
Replacement therapy with protein C concentrate in infants and adolescents with meningococcal sepsis and purpura fulminans ,
, Semin Thromb Hemost, vol.25, p.10632475, 1999.
Protein C replacement in severe meningococcemia: rationale and clinical experience, Clin Infect Dis Off Publ Infect Dis Soc Am, vol.32, p.11303270, 2001. ,
An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia, Blood, vol.96, p.11090052, 2000. ,
Combined antithrombin and protein C supplementation in meningococcal purpura fulminans: a pharmacokinetic study, Intensive Care Med, vol.29, p.12761614, 2003. ,
Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: a randomized, double-blinded, placebo-controlled, dose-finding study, Crit Care Med, vol.31, p.12794428, 2003. ,
Human protein C concentrate in the treatment of purpura fulminans: a retrospective analysis of safety and outcome in 94 pediatric patients, Crit Care Lond Engl, vol.14, p.20723255, 2010. ,
Antigenic variation of pilin regulates adhesion of Neisseria meningitidis to human epithelial cells, Mol Microbiol, vol.8, p.8332064, 1993. ,
Roles of pilin and PilC in adhesion of Neisseria meningitidis to human epithelial and endothelial cells, Proc Natl Acad Sci U A, vol.91, pp.3769-73, 1994. ,
Meningococcal Opa and Opc proteins: their role in colonization and invasion of human epithelial and endothelial cells, Mol Microbiol, vol.10, p.7968528, 1993. ,
Multiplex Genome Engineering Using CRISPR/Cas Systems, Science, vol.339, p.23287718, 2013. ,