Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway, Cell, vol.77, p.7512451, 1994. ,
Leptin and mucosal immunity, Mucosal immunology, vol.5, p.22692456, 2012. ,
Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase, Molecular and cellular biology, vol.11, p.1848670, 1991. ,
JAK3: a novel JAK kinase associated with terminal differentiation of hematopoietic cells, Oncogene, vol.9, p.7518579, 1994. ,
) tyk2, prototype of a novel class of non-receptor tyrosine kinase genes, Oncogene, vol.5, p.2216457, 1990. ,
Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction, The Journal of biological chemistry, vol.271, p.8626374, 1996. ,
STAT heterodimers in immunity: A mixed message or a unique signal, JAK-STAT, vol.2, p.24058793, 2013. ,
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation, Cell, vol.82, p.7543024, 1995. ,
Function of mitochondrial Stat3 in cellular respiration, Science, vol.323, p.19131594, 2009. ,
Stat3 dimerization regulated by reversible acetylation of a single lysine residue, Science, vol.307, p.15653507, 2005. ,
Reversible methylation of promoterbound STAT3 by histone-modifying enzymes, Proceedings of the National Academy of Sciences of the United States of America, vol.107, p.21098664, 2010. ,
CD45 Phosphatase Inhibits STAT3 Transcription Factor Activity in Myeloid Cells and Promotes Tumor-Associated Macrophage Differentiation, Immunity, vol.44, p.26885857, 2016. ,
The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers, Proceedings of the National Academy of Sciences of the United States of America, vol.106, p.19478061, 2009. ,
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T, Proceedings of the National Academy of Sciences of the United States of America, vol.104, p.17360477, 2007. ,
The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation, Nature immunology, vol.16, p.26479789, 2015. ,
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130, Proceedings of the National Academy of Sciences of the United States of America, vol.97, p.10829066, 2000. ,
Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain, Genes to cells: devoted to molecular & cellular mechanisms, vol.4, pp.339-351, 1999. ,
Epidermal growth factor receptor signaling impairs the antiviral activity of interferon-alpha, Hepatology, vol.58, p.23519785, 2013. ,
The Sin3a repressor complex is a master regulator of STAT transcriptional activity, Proceedings of the National Academy of Sciences of the United States of America, vol.109, p.22783022, 2012. ,
Regulation of type I interferon responses, Nat Rev Immunol, vol.14, p.24362405, 2014. ,
Signaling pathways in liver diseases, pp.214-225, 2015. ,
Reparative inflammation takes charge of tissue regeneration, Nature, vol.529, p.26791721, 2016. ,
Principles of liver regeneration and growth homeostasis, Comprehensive Physiology, vol.3, p.23720294, 2013. ,
Advances in liver regeneration, Expert review of gastroenterology & hepatology, vol.8, pp.897-907, 2014. ,
Liver immunology and its role in inflammation and homeostasis, Cellular & molecular immunology, vol.13, pp.267-276, 2016. ,
ICAM-1 triggers liver regeneration through leukocyte recruitment and Kupffer cell-dependent release of TNF-alpha/IL-6 in mice, Gastroenterology, vol.124, p.12612908, 2003. ,
Liver regeneration, Journal of cellular physiology, vol.213, p.17559071, 2007. ,
Revisiting STAT3 signalling in cancer: new and unexpected biological functions, Nature reviews Cancer, vol.14, p.25342631, 2014. ,
STAT3 mutations in the hyper-IgE syndrome, The New England journal of medicine, vol.357, p.17881745, 2007. ,
A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory, Immunity, vol.35, p.22118528, 2011. ,
Interaction between STAT-3 and HNF-3 leads to the activation of liver-specific hepatitis B virus enhancer 1 function, J Virol, vol.76, p.11861839, 2002. ,
HBx protein of hepatitis B virus activates Jak1-STAT signaling, J Biol Chem, vol.273, p.9738022, 1998. ,
HBV-induced ROS accumulation promotes hepatocarcinogenesis through Snail-mediated epigenetic silencing of SOCS3, Cell Death Differ, vol.23, p.26794444, 2016. ,
Signal transducer and activator of transcription 3 is a proviral host factor for hepatitis C virus, Hepatology, vol.58, p.23703790, 2013. ,
Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation, The Journal of experimental medicine, vol.196, p.12208879, 2002. ,
Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B, Proc Natl Acad Sci U S A, vol.98, p.11481452, 2001. ,
The role of signal transducer and activator of transcription 3 in Rift Valley fever virus infection, Virology, vol.496, p.27318793, 2016. ,
HCMV-encoded chemokine receptor US28 mediates proliferative signaling through the IL-6-STAT3 axis, Sci Signal, vol.3, p.20682912, 2010. ,
HCMV activates the IL-6-JAK-STAT3 axis in HepG2 cells and primary human hepatocytes, PLoS ONE, vol.8, p.23555719, 2013. ,
Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10), Proc Natl Acad Sci U S A, vol.97, p.10677520, 2000. ,
Shaping phenotype, function, and survival of dendritic cells by cytomegalovirus-encoded IL-10, J Immunol, vol.173, p.15322202, 2004. ,
The cytomegalovirus homolog of interleukin-10 requires phosphatidylinositol 3-kinase activity for inhibition of cytokine synthesis in monocytes, J Virol, vol.81, p.17121792, 2007. ,
A positive autoregulatory loop of LMP1 expression and STAT activation in epithelial cells latently infected with Epstein-Barr virus, J Virol, vol.77, p.12634372, 2003. ,
Epstein-Barr virus LMP1 activates EGFR, STAT3, and ERK through effects on PKCdelta, J Virol, vol.85, p.21307189, 2011. ,
Epstein-Barr virus-derived EBNA2 regulates STAT3 activation, Biochem Biophys Res Commun, vol.378, p.19032945, 2009. ,
Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI, Science, vol.248, p.2161559, 1990. ,
A single amino acid determines the immunostimulatory activity of interleukin 10, J Exp Med, vol.191, p.10637267, 2000. ,
Human herpesvirus 8 interleukin-6 (vIL-6) signals through gp130 but has structural and receptor-binding properties distinct from those of human IL-6, J Virol, vol.73, p.10482577, 1999. ,
STAT3 activation by KSHV correlates with IL-10, IL-6 and IL-23 release and an autophagic block in dendritic cells, Sci Rep, vol.4, p.24577500, 2014. ,
Signal transducer and activator of transcription 3 (STAT3) and survivin induction by varicella-zoster virus promote replication and skin pathogenesis, Proc Natl Acad Sci U S A, vol.109, p.22190485, 2012. ,
Resveratrol inhibition of varicella-zoster virus replication In vitro, Antiviral Res, vol.72, p.16899306, 2006. ,
plays a critical role in induction of a proinflammatory phenotype of retinal Muller cells following Zika virus infection, Antiviral Res, vol.145, p.28739278, 2017. ,
Zika Virus Persistence in the Central Nervous System and Lymph Nodes of Rhesus Monkeys, Cell, vol.169, p.28457610, 2017. ,
STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling, J Virol, vol.77, p.12743296, 2003. ,
STAT protein interference and suppression of cytokine signal transduction by measles virus V protein, J Virol, vol.77, pp.7635-7644, 2003. ,
Highly pathogenic avian influenza H5N1 virus delays apoptotic responses via activation of STAT3, Sci Rep, vol.6, p.27344974, 2016. ,
Influenza virus non-structural protein 1 (NS1) disrupts interferon signaling, PLoS ONE, vol.5, p.21085662, 2010. ,
The hepatitis E virus ORF3 protein modulates epidermal growth factor receptor trafficking, STAT3 translocation, and the acute-phase response, J Virol, vol.82, p.18448545, 2008. ,
The rabies virus interferon antagonist P protein interacts with activated STAT3 and inhibits Gp130 receptor signaling, J Virol, vol.87, p.23698294, 2013. ,
Human metapneumovirus inhibits the IL-6-induced JAK/STAT3 signalling cascade in airway epithelium, J Gen Virol, vol.95, p.24114793, 2014. ,
Human cytomegalovirus IE1 protein disrupts interleukin-6 signaling by sequestering STAT3 in the nucleus, J Virol, vol.87, p.23903834, 2013. ,
Viral microRNAs Target a Gene Network, Inhibit STAT Activation, and Suppress Interferon Responses. Sci Rep, vol.7, p.28102325, 2017. ,
Angiopoietin-like 4 Increases Pulmonary Tissue Leakiness and Damage during Influenza Pneumonia, Cell Rep, 2015. ,
Common threads in persistent viral infections, J Virol, vol.84, pp.4116-4123, 2010. ,
Viruses and the Diversity of Cell Death, Annu Rev Virol, vol.3, p.27501259, 2016. ,
Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment, Nat Rev Immunol, vol.7, p.17186030, 2007. ,
Cellular STAT3 functions via PCBP2 to restrain Epstein-Barr Virus lytic activation in B lymphocytes, J Virol, vol.89, p.25717101, 2015. ,
STAT3 Regulates Lytic Activation of Kaposi's Sarcoma-Associated Herpesvirus, J Virol, vol.89, p.26339061, 2015. ,
STAT3 participates in transcriptional activation of the C-reactive protein gene by interleukin-6, J Biol Chem, vol.271, p.8621622, 1996. ,
CCL5 as a potential immunotherapeutic target in triple-negative breast cancer, Cell Mol Immunol, vol.10, p.23376885, 2013. ,
Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection, Immunity, vol.17, p.12433371, 2002. ,
URL : https://hal.archives-ouvertes.fr/hal-01061427
Immune responses and immunopathology in acute and chronic viral hepatitis, Nat Rev Immunol, vol.16, p.27374637, 2016. ,
Decline of miR-124 in myeloid cells promotes regulatory T-cell development in hepatitis C virus infection, Immunology, vol.150, p.27753084, 2017. ,
Hepatitis C Virus Induces MDSCs-Like Monocytes through TLR2/PI3K/AKT/STAT3 Signaling, PLoS ONE, vol.12, p.28114346, 2017. ,
Myeloid cells in hepatocellular carcinoma, Hepatology, vol.62, p.25914264, 2015. ,
A dynamic view of hepatitis C virus replication complexes, J Virol, vol.82, p.18715913, 2008. ,
Initiation of hepatitis C virus infection requires the dynamic microtubule network: role of the viral nucleocapsid protein, J Biol Chem, vol.284, p.19269968, 2009. ,
Hepatocellular carcinoma, p.27158749, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01910322
STAT3 as a therapeutic target for Epstein-Barr virus (EBV): associated nasopharyngeal carcinoma, Cancer Lett, vol.330, p.23220625, 2013. ,
STAT3 activation contributes directly to Epstein-Barr virus-mediated invasiveness of nasopharyngeal cancer cells In vitro, Int J Cancer, vol.125, p.19588483, 2009. ,
MUC1 induced by EpsteinBarr virus latent membrane protein 1 causes dissociation of the cell-matrix interaction and cellular invasiveness via STAT signaling, J Virol, vol.81, p.17151127, 2007. ,
Do STAT3 inhibitors have potential in the future for cancer therapy?, Expert Opin Investig Drugs, vol.26, p.28714740, 2017. ,
A novel small-molecule inhibitor of hepatitis C virus replication acts by suppressing signal transducer and activator of transcription 3, J Antimicrob Chemother, vol.70, p.25858355, 2015. ,
Targeting blockage of STAT3 inhibits hepatitis B virus-related hepatocellular carcinoma, Cancer Biol Ther, vol.17, p.26934469, 2016. ,
Therapeutic modulators of STAT signalling for human diseases, Nat Rev Drug Discov, vol.12, p.23903221, 2013. ,
Resveratrol prevents EBV transformation and inhibits the outgrowth of EBV-immortalized human B cells, PLoS ONE, vol.7, p.23251493, 2012. ,
Resveratrol inhibits Epstein Barr Virus lytic cycle in Burkitt's lymphoma cells by affecting multiple molecular targets, Antiviral Res, vol.96, p.22985630, 2012. ,
Using mutagenesis to explore conserved residues in the RNA-binding groove of influenza A virus nucleoprotein for antiviral drug development, Sci Rep, vol.6, p.21662, 2016. ,
Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway, FEBS Lett, vol.584, pp.707-712, 2010. ,
The multi-targeted kinase inhibitor sorafenib inhibits human cytomegalovirus replication, Cell Mol Life Sci, vol.68, p.20803231, 2011. ,
Strategies and Approaches of Targeting STAT3 for Cancer Treatment, ACS Chem Biol, vol.11, p.26730496, 2016. ,
Kinase inhibitors and monoclonal antibodies in oncology: clinical implications, Nat Rev Clin Oncol, vol.13, p.26718105, 2016. ,
Targeting Oncogenic Transcription Factors: Therapeutic Implications of Endogenous STAT Inhibitors, Trends Cancer, vol.3, p.29198438, 2017. ,
Chemistry: Chemical con artists foil drug discovery, Nature, vol.513, p.25254460, 2014. ,
AZD9150 With MEDI4736 in Patients With Advanced Pancreatic, Non-Small Lung and Colorectal Cancer, 2017. ,
Alone and in Combination With Tremelimumab or AZD9150 in Adult Subjects With Relapsed/Refractory DLBCL, 2017. ,
Study to Assess MEDI4736 With Either AZD9150 or AZD5069 in Advanced Solid Tumors & Relapsed Metastatic Squamous Cell Carcinoma of Head & Neck, 2017. ,
Napabucasin: An Update on the First-in-Class Cancer Stemness Inhibitor, Drugs, vol.77, p.28573435, 2017. ,