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Journal articles
Viral manipulation of STAT3: Evade, exploit, and injure
Abstract : Signal transducer and activator of transcription 3 (STAT3) is a key regulator of numerous physiological functions, including the immune response. As pathogens elicit an acute phase response with concerted activation of STAT3, they are confronted with two evolutionary options: either curtail it or employ it. This has important consequences for the host, since abnormal STAT3 function is associated with cancer development and other diseases. This review provides a comprehensive outline of how human viruses cope with STAT3-mediated inflammation and how this affects the host. Finally, we discuss STAT3 as a potential target for antiviral therapy.
Cited literature [98 references]
https://www.hal.inserm.fr/inserm-02171672
Contributor : Myriam Bodescot <>
Submitted on : Wednesday, July 3, 2019 - 10:09:41 AM
Last modification on : Thursday, October 24, 2019 - 4:07:32 PM
Contributor : Myriam Bodescot <>
Submitted on : Wednesday, July 3, 2019 - 10:09:41 AM
Last modification on : Thursday, October 24, 2019 - 4:07:32 PM
File
journal.ppat.1006839.pdf
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