Viral manipulation of STAT3: Evade, exploit, and injure

Abstract : Signal transducer and activator of transcription 3 (STAT3) is a key regulator of numerous physiological functions, including the immune response. As pathogens elicit an acute phase response with concerted activation of STAT3, they are confronted with two evolutionary options: either curtail it or employ it. This has important consequences for the host, since abnormal STAT3 function is associated with cancer development and other diseases. This review provides a comprehensive outline of how human viruses cope with STAT3-mediated inflammation and how this affects the host. Finally, we discuss STAT3 as a potential target for antiviral therapy.
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Armando Andres Roca Suarez, Nicolaas van Renne, Thomas Baumert, Joachim Lupberger. Viral manipulation of STAT3: Evade, exploit, and injure. PLoS Pathogens, Public Library of Science, 2018, 14 (3), pp.e1006839. ⟨10.1371/journal.ppat.1006839⟩. ⟨inserm-02171672⟩

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