Skip to Main content Skip to Navigation
Journal articles

Human Effector CD8 + T Lymphocytes Express TLR3 as a Functional Coreceptor

Abstract : TLR are evolutionarily conserved molecules that play a key role in the initiation of innate antimicrobial immune responses. Through their influence on dendritic cell maturation, these receptors are also thought to indirectly shape the adaptive immune response. However, no data are currently available regarding both TLR expression and function in human CD8+ T cell subsets. We report that a subpopulation of CD8+ T cells, i.e., effector, but neither naive nor central memory cells, constitutively expresses TLR3. Moreover, the ligation of the receptor by a specific agonist in TLR3-expressing CD8+ T cells increased IFN-gamma secretion induced by TCR-dependent and -independent stimulation, without affecting proliferation or specific cytolytic activity. These results thereby suggest that TLR3 ligands can not only indirectly influence the adaptive immune response through modulation of dendritic cell activation, but also directly increase IFN-gamma production by Ag-specific CD8+ T cells. Altogether, the present work might open new perspectives for the use of TLR ligands as adjuvants for immunotherapy.
Document type :
Journal articles
Complete list of metadatas

Cited literature [52 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-02168007
Contributor : Tabiasco Julie <>
Submitted on : Friday, June 28, 2019 - 12:59:37 PM
Last modification on : Monday, May 11, 2020 - 2:11:24 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Julie Tabiasco, Estelle Devevre, Nathalie Rufer, Bruno Salaun, Jean-Charles Cerottini, et al.. Human Effector CD8 + T Lymphocytes Express TLR3 as a Functional Coreceptor. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2006, 177 (12), pp.8708-8713. ⟨10.4049/jimmunol.177.12.8708⟩. ⟨inserm-02168007⟩

Share

Metrics

Record views

109