Skip to Main content Skip to Navigation
Journal articles

Dairy consumption is associated with lower plasma dihydroceramides in women from the D.E.S.I.R. study

Abstract : AIM: In the D.E.S.I.R. cohort, higher consumption of dairy products was associated with lower incidence of hyperglycaemia, and dihydroceramide concentrations were higher in those who progressed to diabetes. Our aim here was to study the relationships between dairy consumption and concentrations of dihydroceramides and ceramides. METHODS: In the D.E.S.I.R. cohort, men and women aged 30-65 years, volunteers from West-Central France, were included in a 9-year follow-up with examinations every 3 years, including food-frequency questionnaires. Two items concerned dairy products (cheese, other dairy products except cheese). At each examination, dihydroceramides and ceramides were determined by mass spectrometry in a cohort subset; also, the 105 people who did not progress to type 2 diabetes were analyzed, as the disorder per se might be a confounding factor. RESULTS: Higher consumption of dairy products (except cheese) was associated with total plasma dihydroceramides during the follow-up, but only in women (P=0.01 for gender interaction). In fact, dihydroceramide levels were lower in women with high vs low consumption (P=0.03), and were significantly increased during follow-up (P=0.01) in low consumers only. There was also a trend for lower ceramides in women with high dairy (except cheese) intakes (P=0.08). Cheese was associated with dihydroceramide and ceramide changes during follow-up (P=0.04 for both), but no clear trend was evident in either low or high consumers. CONCLUSION: These results show that, in women, there is an inverse association between fresh dairy product consumption and predictive markers (dihydroceramides) of type 2 diabetes.
Document type :
Journal articles
Complete list of metadata

Cited literature [29 references]  Display  Hide  Download
Contributor : Frédéric Fumeron Connect in order to contact the contributor
Submitted on : Friday, June 28, 2019 - 10:50:11 AM
Last modification on : Sunday, June 26, 2022 - 4:29:26 AM


Files produced by the author(s)



Frédéric Fumeron, Anthony Nicolas, Jean-Philippe Bastard, Soraya Fellahi, Léonore Wigger, et al.. Dairy consumption is associated with lower plasma dihydroceramides in women from the D.E.S.I.R. study. Diabetes and Metabolism, Elsevier Masson, 2020, 46 (2), pp.144-149. ⟨10.1016/j.diabet.2019.06.002⟩. ⟨inserm-02167796⟩



Record views


Files downloads