Colistin–glycopeptide combinations against multidrug-resistant Acinetobacter baumannii in a mouse model of pneumonia

Abstract : Aim: To assess the effect of colistin-glycopeptide combination against a multidrug-resistant strain of Acinetobacter baumannii. Materials & methods: We used in vitro procedures (Etest method, checkerboard test and kill-time assays) and a mouse model of a carbapenem-resistant A. baumannii pneumonia. Results: The colistin-teicoplanin combination allowed a 74% increase of the survival in the mouse model within the 4 days following bacterial inoculation as compared with saline or colistin alone (p = 0.06). Concurrently, the colistin-vancomycin combination presented a similar efficacy as compared with saline or colistin alone in the mouse model. Conclusion: According to those preliminary results, using the colistin-teicoplanin combination in therapeutic deadlocks encountered in certain multiresistant A. baumannii pneumonia could be envisaged if the results are confirmed.
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Diane Sanderink, Viviane Cassisa, Rachel Chenouard, Rafael Mahieu, Marie Kempf, et al.. Colistin–glycopeptide combinations against multidrug-resistant Acinetobacter baumannii in a mouse model of pneumonia. Future Microbiology, Future Medicine, 2019, 14 (7), pp.581-586. ⟨10.2217/fmb-2019-0022⟩. ⟨inserm-02167761⟩

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