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Colistin–glycopeptide combinations against multidrug-resistant Acinetobacter baumannii in a mouse model of pneumonia
Abstract : Aim: To assess the effect of colistin-glycopeptide combination against a multidrug-resistant strain of Acinetobacter baumannii. Materials & methods: We used in vitro procedures (Etest method, checkerboard test and kill-time assays) and a mouse model of a carbapenem-resistant A. baumannii pneumonia. Results: The colistin-teicoplanin combination allowed a 74% increase of the survival in the mouse model within the 4 days following bacterial inoculation as compared with saline or colistin alone (p = 0.06). Concurrently, the colistin-vancomycin combination presented a similar efficacy as compared with saline or colistin alone in the mouse model. Conclusion: According to those preliminary results, using the colistin-teicoplanin combination in therapeutic deadlocks encountered in certain multiresistant A. baumannii pneumonia could be envisaged if the results are confirmed.
Cited literature [20 references]
https://www.hal.inserm.fr/inserm-02167761
Contributor : Elizabeth Bernardo <>
Submitted on : Friday, June 28, 2019 - 10:27:08 AM
Last modification on : Monday, December 16, 2019 - 4:47:40 PM
Contributor : Elizabeth Bernardo <>
Submitted on : Friday, June 28, 2019 - 10:27:08 AM
Last modification on : Monday, December 16, 2019 - 4:47:40 PM
