M. Abbate, C. Zoja, D. Rottoli, D. Corna, S. Tomasoni et al., Proximal tubular cells promote fibrogenesis by TGF-b 1 -mediated induction of peritubular myofibroblasts, Kidney Int, vol.61, pp.2066-2077, 2002.

R. Abdi, R. N. Smith, L. Makhlouf, N. Najafian, A. D. Luster et al., The role of CC chemokine receptor 5 (CCR5) in islet allograft rejection, Diabetes, vol.51, pp.2489-2495, 2002.

R. Abdi, T. K. Means, T. Ito, R. N. Smith, N. Najafian et al., Differential role of CCR2 in islet and heart allograft rejection: Tissue specificity of chemokine/chemokine receptor function in vivo, J Immunol, vol.172, pp.767-775, 2004.

C. Agostini, F. Calabrese, F. Rea, M. Facco, A. Tosoni et al., Cxcr3 and its ligand CXCL10 are expressed by inflammatory cells infiltrating lung allografts and mediate chemotaxis of T cells at sites of rejection, Am J Pathol, vol.158, pp.1703-1711, 2001.

S. Akashi, M. Sho, H. Kashizuka, K. Hamada, N. Ikeda et al.,

S. Baid-agrawal and U. A. Frei, Kidney-transplant rejection and anti-MICA antibodies, N Engl J Med, vol.358, p.196, 2008.

J. A. Barbara, S. E. Turvey, C. I. Kingsley, B. M. Spriewald, M. Hara et al., Islet allograft rejection can be mediated by CD4 þ , alloantigen experienced, direct pathway T cells of TH1 and TH2 cytokine phenotype, Transplantation, vol.70, pp.1641-1649, 2000.

D. L. Barber, E. J. Wherry, and A. R. , Cutting edge: Rapid in vivo killing by memory CD8 T cells, J Immunol, vol.171, pp.27-31, 2003.

S. Bauer, V. Groh, J. Wu, A. Steinle, J. H. Phillips et al., Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA, Science, vol.285, pp.727-729, 1999.

J. A. Belperio and A. Ardehali, Chemokines and transplant vasculopathy, Circ Res, vol.103, pp.454-466, 2008.

O. Bestard, J. M. Cruzado, M. Mestre, A. Caldes, J. Bas et al., Achieving donor-specific hyporesponsiveness is associated with FoxP3 þ regulatory T cell recruitment in human renal allograft infiltrates, J Immunol, vol.179, pp.4901-4909, 2007.

H. Bian and E. F. Reed, Alloantibody-mediated class I signal transduction in endothelial cells and smooth muscle cells: Enhancement by IFN-g and TNF-a, J Immunol, vol.163, pp.1010-1018, 1999.

H. Bian and E. F. Reed, Anti-HLA class I antibodies transduce signals in endothelial cells resulting in FGF receptor translocation, down-regulation of ICAM-1 and cell proliferation, Transplant Proc, vol.33, p.311, 2001.

D. Brandle, J. Joergensen, G. Zenke, K. Burki, and R. P. Hof, Contribution of donor-specific antibodies to acute allograft rejection: Evidence from B cell-deficient mice, Transplantation, vol.65, pp.1489-1493, 1998.

M. Y. Braun, F. Desalle, L. Moine, A. Pretolani, M. Matthys et al., IL-5 and eosinophils mediate the rejection of fully histoincompatible vascularized cardiac allografts: Regulatory role of alloreactive CD8 þ T lymphocytes and IFN-g, Eur J Immunol, vol.30, pp.1290-1296, 2000.

M. O. Brook, J. K. Wood, and N. D. Jones, The impact of memory T cells on rejection and the induction of tolerance, Transplantation, vol.82, pp.1-9, 2006.

W. J. Burlingham, R. B. Love, E. Jankowska-gan, L. D. Haynes, Q. Xu et al., IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants, J Clin Invest, vol.117, pp.3498-3506, 2007.

J. J. Campbell, G. Haraldsen, J. Pan, J. Rottman, S. Qin et al., The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells, Nature, vol.400, pp.776-780, 1999.

G. Castellano, R. Melchiorre, A. Loverre, P. Ditonno, V. Montinaro et al., Therapeutic targeting of classical and lectin pathways of complement protects from ischemia-reperfusion-induced renal damage, Am J Pathol, vol.176, pp.1648-1659, 2010.

S. Celli, M. L. Albert, and P. Bousso, Visualizing the innate and adaptive immune responses underlying allograft rejection by two-photon microscopy, Nat Med, vol.17, pp.744-749, 2011.
URL : https://hal.archives-ouvertes.fr/pasteur-01402079

J. Chen, B. Fabry, E. L. Schiffrin, and N. Wang, Twisting integrin receptors increases endothelin-1 gene expression in endothelial cells, Am J Physiol Cell Physiol, vol.280, pp.1475-1484, 2001.

J. Cheng, A. Torkamani, R. K. Grover, T. M. Jones, D. I. Ruiz et al., Ectopic B-cell clusters that infiltrate transplanted human kidneys are clonal, Proc Natl Acad Sci, vol.108, pp.5560-5565, 2011.

A. S. Chong and M. L. Alegre, The impact of infection and tissue damage in solid-organ transplantation, Nat Rev Immunol, vol.12, pp.459-471, 2012.

K. Christopher, T. F. Mueller, C. Ma, Y. Liang, and D. L. Perkins, Analysis of the innate and adaptive phases of allograft rejection by cluster analysis of transcriptional profiles, J Immunol, vol.169, pp.522-530, 2002.

M. R. Clatworthy, C. J. Watson, G. Plotnek, V. Bardsley, A. N. Chaudhry et al., B-cell-depleting induction therapy and acute cellular rejection, N Engl J Med, vol.360, pp.2683-2685, 2009.

J. G. Cogan, S. V. Subramanian, J. A. Polikandriotis, R. J. Kelm, and A. R. Strauch, Vascular smooth muscle a-actin gene transcription during myofibroblast differentiation requires Sp1/3 protein binding proximal to the MCAT enhancer, J Biol Chem, vol.277, pp.36433-36442, 2002.

R. Colobran, N. Casamitjana, A. Roman, R. Faner, E. Pedrosa et al., Copy number variation in the CCL4L gene is associated with susceptibility to acute rejection in lung transplantation, Genes Immun, vol.10, pp.254-259, 2009.

S. L. Constant, B lymphocytes as antigen-presenting cells for CD4, 1999.

, T cell priming in vivo, J Immunol, vol.162, pp.5695-5703

J. E. Cooper, J. Gralla, L. Cagle, R. Goldberg, L. Chan et al., Inferior kidney allograft outcomes in patients with de novo donor-specific antibodies are due to acute rejection episodes, Transplantation, vol.91, pp.1103-1109, 2011.

F. G. Cosio, D. J. Lager, E. C. Lorenz, H. Amer, J. M. Gloor et al., Significance and implications of capillaritis during acute rejection of kidney allografts, Transplantation, vol.89, pp.1088-1094, 2010.

J. D. Coudert, C. Coureau, and J. C. Guery, Preventing NK cell activation by donor dendritic cells enhances allospecific CD4 T cell priming and promotes Th type 2 responses to transplantation antigens, J Immunol, vol.169, pp.2979-2987, 2002.

S. Coupel, A. Moreau, M. Hamidou, V. Horejsi, J. P. Soulillou et al., Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation, Blood, vol.109, pp.2806-2814, 2007.

B. M. Coupes, C. G. Newstead, C. D. Short, and P. E. Brenchley, Transforming growth factor b 1 in renal allograft recipients, Transplantation, vol.57, pp.1727-1731, 1994.

C. Crescioli, A. Buonamano, S. Scolletta, M. Sottili, M. Francalanci et al., Predictive role of pretransplant serum CXCL10 for cardiac acute rejection, Transplantation, vol.87, pp.249-255, 2009.

M. Croft, Costimulation of T cells by OX40, 4-1BB, and CD27, Cytokine Growth Factor Rev, vol.14, pp.265-273, 2003.

M. C. Cuturi, M. Murphy, M. P. Costa-giomi, R. Weinmann, B. Perussia et al., Independent regulation Effector Mechanisms of Rejection Cite this article as Cold Spring Harb Perspect Med, J Exp Med, vol.3, pp.1581-1594, 1987.

M. C. Cuturi, I. Anegon, F. Sherman, R. Loudon, S. C. Clark et al., Production of hematopoietic colony-stimulating factors by human natural killer cells, J Exp Med, vol.169, pp.569-583, 1989.

S. Deng, M. Dj, X. Huang, M. M. Lian, M. Mohiuddin et al., Cutting edge: Transplant tolerance induced by anti-CD45RB requires B lymphocytes, J Immunol, vol.178, pp.6028-6032, 2007.

C. Deteix, V. Attuil-audenis, A. Duthey, N. Patey, B. Mcgregor et al., Intragraft Th17 infiltrate promotes lymphoid neogenesis and hastens clinical chronic rejection, J Immunol, vol.184, pp.5344-5351, 2010.

O. Dewald, P. Zymek, K. Winkelmann, A. Koerting, G. Ren et al., CCL2/monocyte chemoattractant protein-1 regulates inflammatory responses critical to healing myocardial infarcts, Circ Res, vol.96, pp.881-889, 2005.

R. Dikow, L. E. Becker, M. Schaier, R. Waldherr, M. L. Gross et al., In renal transplants with delayed graft function chemokines and chemokine receptor expression predict long-term allograft function, Transplantation, vol.90, pp.771-776, 2010.

N. Dilek, N. Poirier, C. Usal, B. Martinet, G. Blancho et al., Control of transplant tolerance and intragraft regulatory T cell localization by myeloid-derived suppressor cells and CCL5, J Immunol, vol.188, pp.4209-4216, 2012.

D. J. Dilillo, R. Griffiths, S. V. Seshan, C. M. Magro, P. Ruiz et al., B lymphocytes differentially influence acute and chronic allograft rejection in mice, J Immunol, vol.186, pp.2643-2654, 2011.

R. Ding, B. Li, T. Muthukumar, D. Dadhania, M. Medeiros et al., CD103 mRNA levels in urinary cells predict acute rejection of renal allografts, Transplantation, vol.75, pp.1307-1312, 2003.

Q. Ding, M. Yeung, G. Camirand, Q. Zeng, H. Akiba et al., Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice, J Clin Invest, vol.121, pp.3645-3656, 2011.

N. C. Direkze, S. J. Forbes, M. Brittan, T. Hunt, R. Jeffery et al., Multiple organ engraftment by bone-marrow-derived myofibroblasts and fibroblasts in bone-marrow-transplanted mice, Stem Cells, vol.21, pp.514-520, 2003.

D. Dragun, Humoral responses directed against nonhuman leukocyte antigens in solid-organ transplantation, Transplantation, vol.86, pp.1019-1025, 2008.

D. Dragun, D. N. Muller, J. H. Brasen, L. Fritsche, M. Nieminenkelha et al., Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection, N Engl J Med, vol.352, pp.558-569, 2005.

D. Dragun, J. Scornik, and M. Hu, Kidneytransplant rejection and anti-MICA antibodies, N Engl J Med, vol.358, 0196.

F. J. Dugre, S. Gaudreau, M. Belles-isles, I. Houde, and R. Roy, Cytokine and cytotoxic molecule gene expression determined in peripheral blood mononuclear cells in the diagnosis of acute renal rejection, Transplantation, vol.70, pp.1074-1080, 2000.

D. Duluc, Y. Delneste, F. Tan, M. P. Moles, L. Grimaud et al., Tumorassociated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells, Blood, vol.110, pp.4319-4330, 2007.

A. E. El-agroudy, N. A. Hassan, M. A. Foda, A. M. Ismail, E. A. El-sawy et al., Effect of angiotensin II receptor blocker on plasma levels of TGF-b 1 and interstitial fibrosis in hypertensive kidney transplant patients, Am J Nephrol, vol.23, pp.300-306, 2003.

T. El-sawy, J. A. Belperio, R. M. Strieter, D. G. Remick, and R. L. Fairchild, Inhibition of polymorphonuclear leukocytemediated graft damage synergizes with short-term costimulatory blockade to prevent cardiac allograft rejection, Circulation, vol.112, pp.320-331, 2005.

D. E. Epperson and J. S. Pober, Antigen-presenting function of human endothelial cells. Direct activation of resting CD8 T cells, J Immunol, vol.153, pp.5402-5412, 1994.

T. Fahim, G. A. Bohmig, M. Exner, N. Huttary, H. Kerschner et al., The cellular lesion of humoral rejection: Predominant recruitment of monocytes to peritubular and glomerular capillaries, Am J Transplant, vol.7, pp.385-393, 2007.

N. M. Fahmy, M. H. Yamani, R. C. Starling, N. B. Ratliff, J. B. Young et al., Chemokine and receptor-gene expression during early and late acute rejection episodes in human cardiac allografts, Transplantation, vol.75, pp.2044-2047, 2003.

J. M. Fan, Y. Y. Ng, P. A. Hill, D. J. Nikolic-paterson, W. Mu et al., Transforming growth factor-b regulates tubular epithelial-myofibroblast transdifferentiation in vitro, Kidney Int, vol.56, pp.1455-1467, 1999.

W. R. Farid, Q. Pan, A. J. Van-der-meer, P. E. De-ruiter, V. Ramakrishnaiah et al., Hepatocytederived microRNAs as serum biomarkers of hepatic injury and rejection after liver transplantation, Liver Transpl, vol.18, pp.290-297, 2012.

A. M. Fong, L. A. Robinson, D. A. Steeber, T. F. Tedder, Y. O. Imai et al., Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow, J Exp Med, vol.188, pp.1413-1419, 1998.

A. Foussat, A. Coulomb-l'hermine, J. Gosling, R. Krzysiek, I. Durand-gasselin et al., Fractalkine receptor expression by T lymphocyte subpopulations and in vivo production of fractalkine in human, Eur J Immunol, vol.30, pp.87-97, 2000.

N. G. Frangogiannis, The immune system and cardiac repair, Pharmacol Res, vol.58, pp.88-111, 2008.

B. H. Friedman, J. H. Wolf, L. Wang, M. E. Putt, A. Shaked et al., Serum cytokine profiles associated with early allograft dysfunction in patients undergoing liver transplantation, Liver Transpl, vol.18, pp.166-176, 2012.

, NK cells in kidney biopsies from patients with donor-specific antibodies: Evidence for NK cell involvement in antibody-mediated rejection, Am J Transplant, vol.10, pp.1812-1822

L. Hilbrands, A. Hoitsma, and J. Wetzels, Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection, N Engl J Med, vol.352, pp.2027-2028, 2005.

T. Hirohashi, C. M. Chase, D. Pelle, P. Sebastian, D. Alessandrini et al., A novel pathway of chronic allograft rejection mediated by NK cells and alloantibody, Am J Transplant, vol.12, pp.313-321, 2012.

J. Ho, D. N. Rush, I. W. Gibson, M. Karpinski, L. Storsley et al., Early urinary CCL2 is associated with the later development of interstitial fibrosis and tubular atrophy in renal allografts, Transplantation, vol.90, pp.394-400, 2010.

A. Hoerning, K. Koss, D. Datta, L. Boneschansker, C. N. Jones et al., Subsets of human CD4 þ regulatory T cells express the peripheral homing receptor CXCR3, Eur J Immunol, vol.41, pp.2291-2302, 2011.

U. Hoffmann, S. Segerer, P. Rummele, B. Kruger, M. Pietrzyk et al., Expression of the chemokine receptor CXCR3 in human renal allografts-A prospective study, Nephrol Dial Transplant, vol.21, pp.1373-1381, 2006.

U. Hoffmann, T. Bergler, S. Segerer, P. Rummele, B. Kruger et al., Impact of chemokine receptor CX3CR1 in human renal allograft rejection, Transpl Immunol, vol.23, pp.204-208, 2010.

U. E. Hopken, J. Droese, J. P. Li, J. Joergensen, D. Breitfeld et al., The chemokine receptor CCR7 controls lymph node-dependent cytotoxic T cell priming in alloimmune responses, Eur J Immunol, vol.34, pp.461-470, 2004.

P. H. Horne, J. M. Zimmerer, M. G. Fisher, K. E. Lunsford, G. Nadasdy et al., Critical role of effector macrophages in mediating CD4-dependent alloimmune injury of transplanted liver parenchymal cells, J Immunol, vol.181, pp.1224-1231, 2008.

H. Hu, J. Kwun, B. D. Aizenstein, and S. J. Knechtle, Noninvasive detection of acute and chronic injuries in human renal transplant by elevation of multiple cytokines/chemokines in urine, Transplantation, vol.87, pp.1814-1820, 2009.

N. Huser, C. Tertilt, K. Gerauer, S. Maier, T. Traeger et al., CCR4-deficient mice show prolonged graft survival in a chronic cardiac transplant rejection model, Eur J Immunol, vol.35, pp.128-138, 2005.

T. Imai, K. Hieshima, C. Haskell, M. Baba, M. Nagira et al., Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion, Cell, vol.91, pp.521-530, 1997.

N. Issa, F. G. Cosio, J. M. Gloor, S. Sethi, P. G. Dean et al., Transplant glomerulopathy: Risk and prognosis related to anti-human leukocyte antigen class II antibody levels, Transplantation, vol.86, pp.681-685, 2008.

A. Ito, H. Shimura, A. Nitahara, K. Tomiyama, M. Ito et al., NK cells contribute to the skin graft rejection promoted by CD4 þ T cells activated through the indirect allorecognition pathway, Int Immunol, vol.20, pp.1343-1349, 2008.

A. Iwasaki and R. Medzhitov, Regulation of adaptive immunity by the innate immune system, Science, vol.327, pp.291-295, 2010.

J. A. Jackson, E. J. Kim, B. Begley, J. Cheeseman, T. Harden et al., Urinary chemokines CXCL9 and CXCL10 are noninvasive markers of renal allograft rejection and BK viral infection, Am J Transplant, vol.11, pp.2228-2234, 2011.

A. M. Jackson, D. P. Lucas, J. K. Melancon, and N. M. Desai, Clinical relevance and IgG subclass determination of non-HLA antibodies identified using endothelial cell precursors isolated from donor blood, Transplantation, vol.92, pp.54-60, 2011.

J. Ji, Y. Y. Yu, H. Chen, X. X. Deng, B. Y. Shen et al., Perforin and granzyme B expression in liver allograft rejection, Zhonghua Gan Zang Bing Za Zhi, vol.12, pp.325-327, 2004.

Y. L. Jiang, A. G. Dai, Q. F. Li, and R. C. Hu, Transforming growth factor-b1 induces transdifferentiation of fibroblasts into myofibroblasts in hypoxic pulmonary vascular remodeling, Acta Biochim Biophys Sin (Shanghai), vol.38, pp.29-36, 2006.

M. D. Jose, L. Meur, Y. Atkins, R. C. Chadban, and S. J. , Blockade of macrophage colony-stimulating factor reduces macrophage proliferation and accumulation in renal allograft rejection, Am J Transplant, vol.3, pp.294-300, 2003.

W. Jungraithmayr, I. Inci, M. Bain, S. Hillinger, S. Korom et al., Distribution of macrophages and T cells in syngrafts and allografts after experimental rat lung transplantation, Immunobiology, vol.215, pp.206-214, 2010.

Y. Kakuta, M. Okumi, S. Miyagawa, K. Tsutahara, T. Abe et al., Blocking of CCR5 and CXCR3 suppresses the infiltration of macrophages in acute renal allograft rejection, Transplantation, vol.93, pp.24-31, 2012.

M. Kamoun and R. A. Grossman, Kidney-transplant rejection and anti-MICA antibodies, N Engl J Med, vol.358, p.195, 2008.

R. L. Kedainis, M. J. Koch, D. C. Brennan, and H. Liapis, Focal C4d þ in renal allografts is associated with the presence of donor-specific antibodies and decreased allograft survival, Am J Transplant, vol.9, pp.812-819, 2009.

M. R. Keller and W. J. Burlingham, Loss of tolerance to self after transplant, Semin Immunopathol, vol.33, pp.105-110, 2011.

S. Kennard, H. Liu, and B. Lilly, Transforming growth factor-b (TGF-1) down-regulates Notch3 in fibroblasts to promote smooth muscle gene expression, J Biol Chem, vol.283, pp.1324-1333, 2008.

J. Kim, C. K. Chang, T. Hayden, F. C. Liu, J. Benjamin et al., The activating immunoreceptor NKG2D and its ligands are involved in allograft transplant rejection, J Immunol, vol.179, pp.6416-6420, 2007.

C. I. Kingsley, M. Karim, A. R. Bushell, and K. J. Wood, CD25 teritis: No association with markers of humoral rejection or with inferior outcome, Nephrol Dial Transplant, vol.24, pp.1979-1986, 2002.

S. M. Krams, J. C. Villanueva, M. B. Quinn, and O. M. Martinez, Expression of the cytotoxic T cell mediator granzyme B during liver allograft rejection, Transpl Immunol, vol.3, pp.162-166, 1995.

A. Kroemer, X. Xiao, N. Degauque, K. Edtinger, H. Wei et al., The innate NK cells, allograft rejection, and a key role for IL-15, J Immunol, vol.180, pp.7818-7826, 2008.

J. Kwun, S. M. Hazinedaroglu, E. Schadde, H. A. Kayaoglu, J. Fechner et al., Unaltered graft survival and intragraft lymphocytes infiltration in the cardiac allograft of CXCR3 2/2 mouse recipients, Am J Transplant, vol.8, pp.1593-1603, 2008.

S. Laffont, C. Seillet, J. Ortaldo, J. D. Coudert, and J. C. Guery, Natural killer cells recruited into lymph nodes inhibit alloreactive T-cell activation through perforin-mediated killing of donor allogeneic dendritic cells, Blood, vol.112, pp.661-671, 2008.
URL : https://hal.archives-ouvertes.fr/inserm-00306011

W. G. Land, The role of postischemic reperfusion injury and other nonantigen-dependent inflammatory pathways in transplantation, Transplantation, vol.79, pp.505-514, 2005.

D. F. Larosa, A. H. Rahman, and L. A. Turka, The innate immune system in allograft rejection and tolerance, J Immunol, vol.178, pp.7503-7509, 2007.

C. Lawson, A. L. Holder, R. E. Stanford, J. Smith, and M. L. Rose, Anti-intercellular adhesion molecule-1 antibodies in sera of heart transplant recipients: A role in endothelial cell activation, Transplantation, vol.80, pp.264-271, 2005.

E. Lazzeri, M. Rotondi, B. Mazzinghi, L. Lasagni, A. Buonamano et al., High CXCL10 expression in rejected kidneys and predictive role of pretransplant serum CXCL10 for acute rejection and chronic allograft nephropathy, Transplantation, vol.79, pp.1215-1220, 2005.

I. Lee, L. Wang, A. D. Wells, Q. Ye, R. Han et al., Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism, J Immunol, vol.171, pp.6929-6935, 2003.

I. Lee, L. Wang, A. D. Wells, M. E. Dorf, E. Ozkaynak et al., Recruitment of FoxP3 þ Tregulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor, J Exp Med, vol.201, pp.1037-1044, 2005.

C. Lefaucheur, C. Suberbielle-boissel, G. S. Hill, D. Nochy, J. Andrade et al., Clinical relevance of preformed HLA donor-specific antibodies in kidney transplantation, Am J Transplant, vol.8, pp.324-331, 2008.

C. Lefaucheur, D. Nochy, J. Andrade, J. Verine, C. Gautreau et al., Comparison of combination plasmapheresis/IVIg/anti-CD20 versus high-dose IVIg in the treatment of antibody-mediated rejection, Am J Transplant, vol.9, pp.1099-1107, 2009.

C. Lefaucheur, A. Loupy, G. S. Hill, J. Andrade, D. Nochy et al., Preexisting donor-specific HLA antibodies predict outcome in kidney transplantation, J Am Soc Nephrol, vol.21, pp.1398-1406, 2010.

L. Texier, L. , T. P. Lavault, A. Usal, C. Merieau et al., Long-term allograft tolerance is characterized by the accumulation of B cells exhibiting an inhibited profile, Am J Transplant, vol.11, pp.429-438, 2011.

X. C. Li, W. M. Baldwin, and . Iii, NK cells: New partners in antibody-triggered chronic rejection, Am J Transplant, vol.12, pp.275-276, 2012.

B. Li, C. Hartono, R. Ding, V. K. Sharma, R. Ramaswamy et al., Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine, N Engl J Med, vol.344, pp.947-954, 2001.

Y. Li, T. Koshiba, A. Yoshizawa, Y. Yonekawa, K. Masuda et al., Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation, Am J Transplant, vol.4, pp.2118-2125, 2004.

J. Li, J. A. Deane, N. V. Campanale, J. F. Bertram, and S. D. Ricardo, The contribution of bone marrow-derived cells to the development of renal interstitial fibrosis, Stem Cells, vol.25, pp.697-706, 2007.

L. Li, A. Chen, A. Chaudhuri, N. Kambham, T. Sigdel et al., Compartmental localization and clinical relevance of MICA antibodies after renal transplantation, Transplantation, vol.89, pp.312-319, 2010.

J. Li, G. Chen, P. Ye, S. Wang, K. Zhang et al., CCR5 blockade in combination with cyclosporine increased cardiac graft survival and generated alternatively activated macrophages in primates, J Immunol, vol.186, pp.3753-3761, 2011.

H. Li, H. Y. Xie, L. Zhou, X. W. Feng, W. L. Wang et al., Copy number variation in CCL3L1 gene is associated with susceptibility to acute rejection in patients after liver transplantation, Clin Transplant, vol.26, pp.314-321, 2012.

D. Lin, H. Lavender, E. J. Soilleux, O. 'callaghan, and C. A. , NFkB regulates MICA gene transcription in endothelial cell through a genetically inhibitable control site, J Biol Chem, vol.287, pp.4299-4310, 2012.

S. Lindert, L. Wickert, I. Sawitza, E. Wiercinska, A. M. Gressner et al., Transdifferentiation-dependent expression of a-SMA in hepatic stellate cells does not involve TGF-b pathways leading to coinduction of collagen type I and thrombospondin-2, Matrix Biol, vol.24, pp.198-207, 2005.

X. Liu, P. Mishra, S. Yu, J. Beckmann, M. Wendland et al., Tolerance induction towards cardiac allografts under costimulation blockade is impaired in CCR7-deficient animals but can be restored by adoptive transfer of syngeneic plasmacytoid dendritic cells, Eur J Immunol, vol.41, pp.611-623, 2011.

D. J. Lo, T. A. Weaver, D. E. Kleiner, R. B. Mannon, L. M. Jacobson et al., Chemokines and their receptors in human renal allotransplantation, Transplantation, vol.91, pp.70-77, 2011.

G. Lombardi, S. Sidhu, M. Daly, J. R. Batchelor, W. Makgoba et al., Are primary alloresponses truly primary?, Int Immunol, vol.2, pp.9-13, 1990.

J. M. Lorenzen, I. Volkmann, J. Fiedler, M. Schmidt, I. Scheffner et al., Urinary miR-210 as a mediator of acute T-cell mediated rejection in renal allograft recipients, Am J Transplant, vol.11, pp.2221-2227, 2011.

J. J. Lozano, A. Pallier, M. Martinez-llordella, R. Danger, M. Lopez et al., Comparison of transcriptional and blood cell-phenotypic markers between operationally tolerant liver and kidney recipients, Am J Transplant, vol.11, pp.1916-1926, 2011.

K. C. Lu, A. Jaramillo, R. L. Lecha, R. B. Schuessler, A. Aloush et al., Interleukin-6 and interferon-g gene polymorphisms in the development of bronchiolitis obliterans syndrome after lung transplantation, Transplantation, vol.74, pp.1297-1302, 2002.

J. G. Lucas, J. P. Co, U. T. Nwaogwugwu, I. Dosani, and K. K. Sureshkumar, Antibody-mediated rejection in kidney transplantation: An update, Expert Opin Pharmacother, vol.12, pp.579-592, 2011.

C. N. Lumeng, J. L. Bodzin, and A. R. Saltiel, Obesity induces a phenotypic switch in adipose tissue macrophage polarization, J Clin Invest, vol.117, pp.175-184, 2007.

R. P. Macdermott, Alterations of the mucosal immune system in inflammatory bowel disease, J Gastroenterol, vol.31, pp.907-916, 1996.

C. B. Madsen, A. Norgaard, M. Iversen, and L. P. Ryder, Elevated mRNA levels of CTLA-4, FoxP3, and granzyme B in BAL, but not in blood, during acute rejection of lung allografts, Transpl Immunol, vol.24, pp.26-32, 2010.

A. B. Magil, Infiltrating cell types in transplant glomerulitis: Relationship to peritubular capillary C4d deposition, Am J Kidney Dis, vol.45, pp.1084-1089, 2005.

A. B. Magil and K. J. Tinckam, Focal peritubular capillary C4d deposition in acute rejection, Nephrol Dial Transplant, vol.21, pp.1382-1388, 2006.

B. Mahesh, H. S. Leong, A. Mccormack, P. Sarathchandra, A. Holder et al., Autoantibodies to vimentin cause accelerated rejection of cardiac allografts, Am J Pathol, vol.170, pp.1415-1427, 2007.

S. Maier, C. Tertilt, N. Chambron, K. Gerauer, N. Huser et al., Inhibition of natural killer cells results in acceptance of cardiac allografts in CD28, vol.2, 2001.

, Nat Med, vol.7, pp.557-562

T. D. Manes and J. S. Pober, Antigen presentation by human microvascular endothelial cells triggers ICAM-1-dependent transendothelial protrusion by, and fractalkine-dependent transendothelial migration of, effector memory CD4 þ T cells, J Immunol, vol.180, pp.8386-8392, 2008.

T. D. Manes, S. L. Shiao, T. J. Dengler, and J. S. Pober, TCR signaling antagonizes rapid IP-10-mediated transendothelial migration of effector memory CD4 þ T cells, J Immunol, vol.178, pp.3237-3243, 2007.

A. Mantovani, A. Sica, S. Sozzani, P. Allavena, A. Vecchi et al., The chemokine system in diverse forms of macrophage activation and polarization, Trends Immunol, vol.25, pp.677-686, 2004.

Q. Mao, P. I. Terasaki, J. Cai, K. Briley, P. Catrou et al., Extremely high association between appearance of HLA antibodies and failure of kidney grafts in a five-year longitudinal study, Am J Transplant, vol.7, pp.864-871, 2007.

Q. Mao, P. I. Terasaki, J. Cai, N. El-awar, and L. Rebellato, Analysis of HLA class I specific antibodies in patients with failed allografts, Transplantation, vol.83, pp.54-61, 2007.

Y. Mao, M. Wang, Q. Zhou, J. J. Wang, Y. Peng et al., CXCL10 and CXCL13 Expression were highly up-regulated in peripheral blood mononuclear cells in acute rejection and poor response to anti-rejection therapy, J Clin Immunol, vol.31, pp.414-418, 2011.

L. Martinez-dolz, L. Almenar, E. Reganon, V. Vila, R. Sanchezsoriano et al., What is the best biomarker for diagnosis of rejection in heart transplantation, Clin Transplant, vol.23, pp.672-680, 2009.

M. Martinez-llordella, I. Puig-pey, G. Orlando, M. Ramoni, G. Tisone et al., Multiparameter immune profiling of operational tolerance in liver transplantation, Am J Transplant, vol.7, pp.309-319, 2007.

M. Martinez-llordella, J. J. Lozano, I. Puig-pey, G. Orlando, G. Tisone et al., Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients, J Clin Invest, vol.118, pp.2845-2857, 2008.

A. J. Matas, A. Humar, K. J. Gillingham, W. D. Payne, R. W. Gruessner et al., Five preventable causes of kidney graft loss in the 1990s: A single-center analysis, Kidney Int, vol.62, pp.704-714, 2002.

M. Matz, J. Beyer, D. Wunsch, M. F. Mashreghi, M. Seiler et al., Early post-transplant urinary IP-10 expression after kidney transplantation is predictive of short-and long-term graft function, Kidney Int, vol.69, pp.1683-1690, 2006.

R. M. Mcdouall, P. Batten, A. Mccormack, M. H. Yacoub, and M. L. Rose, MHC class II expression on human heart microvascular endothelial cells: Exquisite sensitivity to interferon-g and natural killer cells, Transplantation, vol.64, pp.1175-1180, 1997.

M. E. Mcnerney, K. M. Lee, P. Zhou, L. Molinero, M. Mashayekhi et al., Role of natural killer cell subsets in cardiac allograft rejection, Am J Transplant, vol.6, pp.505-513, 2006.

H. U. Meier-kriesche, J. D. Schold, and B. Kaplan, Long-term renal allograft survival: Have we made significant progress or is it time to rethink our analytic and therapeutic strategies?, Am J Transplant, vol.4, pp.1289-1295, 2004.

M. Mengel, B. Sis, M. Haas, R. B. Colvin, P. F. Halloran et al., Banff 2011 meeting report: New concepts in antibody-mediated rejection, Am J Transplant, vol.12, pp.563-570, 2012.

T. Meyer-ter-vehn, S. Sieprath, B. Katzenberger, S. Gebhardt, F. Grehn et al., Contractility as a prerequisite for TGF-b-induced myofibroblast transdifferentiation in human tenon fibroblasts, Invest Ophthalmol Vis Sci, vol.47, pp.4895-4904, 2006.

S. A. Mezzano, C. A. Aros, A. Droguett, M. E. Burgos, L. G. Ardiles et al., Renal angiotensin II up-regulation and myofibroblast activation in human membranous nephropathy, Kidney Int Suppl, vol.86, pp.39-45, 2003.

M. Miura, T. El-sawy, and F. L. Fairchild, Neutrophils mediate parenchymal tissue necrosis and accelerate the rejection of complete major histocompatibility complex-disparate cardiac allografts in the absence of interferon-g, Am J Pathol, vol.162, pp.509-519, 2003.

S. J. Molesworth-kenyon, J. E. Oakes, and R. N. Lausch, A novel role for neutrophils as a source of T cell-recruiting chemokines IP-10 and Mig during the DTH response to HSV-1 antigen, J Leukoc Biol, vol.77, pp.552-559, 2005.

R. A. Montgomery, M. A. Hardy, S. C. Jordan, L. C. Racusen, L. E. Ratner et al., Consensus opinion from the antibody working group on the diagnosis, reporting, and risk assessment for antibody-mediated rejection and desensitization protocols, Transplantation, vol.78, pp.181-185, 2004.

R. A. Montgomery, B. E. Lonze, K. E. King, E. S. Kraus, L. M. Kucirka et al., Desensitization in HLA-incompatible kidney recipients and survival, N Engl J Med, vol.365, pp.318-326, 2011.

J. R. Montgomery, J. C. Berger, D. S. Warren, N. T. James, R. A. Montgomery et al., Outcomes of ABO-incompatible kidney transplantation in the United States, Transplantation, vol.93, pp.603-609, 2012.

D. M. Mosser and J. P. Edwards, Exploring the full spectrum of macrophage activation, Nat Rev Immunol, vol.8, pp.958-969, 2008.

V. F. Moxham, J. Karegli, R. E. Phillips, K. L. Brown, T. T. Tapmeier et al., Homeostatic proliferation of lymphocytes results in augmented memory-like function and accelerated allograft rejection, J Immunol, vol.180, pp.3910-3918, 2008.

O. Nadazdin, S. Boskovic, T. Murakami, G. Tocco, R. N. Smith et al., Host alloreactive memory T cells influence tolerance to kidney allografts in nonhuman primates, Sci Transl Med, vol.3, pp.86-51, 2011.

H. Nafady-hego, Y. Li, H. Ohe, X. Zhao, N. Satoda et al., The generation of donor-specific CD4 liver transplantation, Transplantation, vol.90, pp.1547-1555, 2010.

B. J. Nankivell, R. J. Borrows, C. L. Fung, P. J. O'connell, R. D. Allen et al., The natural history of chronic allograft nephropathy, N Engl J Med, vol.349, pp.2326-2333, 2003.

G. L. Nelsestuen, M. B. Martinez, M. I. Hertz, K. Savik, and C. H. Wendt, Proteomic identification of human neutrophil a-defensins in chronic lung allograft rejection, Proteomics, vol.5, pp.1705-1713, 2005.

D. C. Neujahr, S. D. Perez, A. Mohammed, O. Ulukpo, E. C. Lawrence et al., Cumulative exposure to g interferon-dependent chemokines CXCL9 and CXCL10 correlates with worse outcome after lung transplant, Am J Transplant, vol.12, pp.438-446, 2012.

K. A. Newell, A. Asare, A. D. Kirk, T. D. Gisler, K. Bourcier et al., Identification of a B cell signature associated with renal transplant tolerance in humans, J Clin Invest, vol.120, pp.1836-1847, 2010.

Y. H. Ng, M. H. Oberbarnscheidt, H. C. Chandramoorthy, R. Hoffman, and G. Chalasani, B cells help alloreactive T cells differentiate into memory T cells, Am J Transplant, vol.10, pp.1970-1980, 2010.

V. Nickeleit, M. Zeiler, F. Gudat, G. Thiel, and M. J. Mihatsch, Detection of the complement degradation product C4d in renal allografts: Diagnostic and therapeutic implications, J Am Soc Nephrol, vol.13, pp.242-251, 2002.

M. Niimi, M. Hara, O. Witzke, P. J. Morris, and K. J. Wood, Donor resting B cells induce indefinite prolongation of fully allogeneic cardiac grafts when delivered with antiimmunoglobulin-D monoclonal antibody: Evidence for tolerogenicity of donor resting B cells in vivo, Transplantation, vol.66, pp.1786-1792, 1998.

H. Noorchashm, A. J. Reed, S. Y. Rostami, R. Mozaffari, G. Zekavat et al., B cell-mediated antigen presentation is required for the pathogenesis of acute cardiac allograft rejection, J Immunol, vol.177, pp.7715-7722, 2006.

T. Nozaki, H. Amano, A. Bickerstaff, C. G. Orosz, A. C. Novick et al., Antibody-mediated rejection of cardiac allografts in CCR5-deficient recipients, J Immunol, vol.179, pp.5238-5245, 2007.

J. C. Ochando, N. R. Krieger, and J. S. Bromberg, Direct versus indirect allorecognition: Visualization of dendritic cell distribution and interactions during rejection and tolerization, Am J Transplant, vol.6, pp.2488-2496, 2006.

A. O. Ojo, J. A. Hanson, R. A. Wolfe, A. B. Leichtman, A. Ly et al., Long-term survival in renal transplant recipients with graft function, Kidney Int, vol.57, pp.307-313, 2000.

M. Ozawa, P. I. Terasaki, J. H. Lee, R. Castro, J. Alberu et al., 14th International HLA and Immunogenetics Workshop: Report on the prospective chronic rejection project, vol.69, pp.174-179, 2007.

A. W. Paantjens, E. A. Van-de-graaf, J. M. Kwakkel-van-erp, T. Hoefnagel, D. A. Van-kessel et al., Lung transplantation affects expression of the chemokine receptor type 4 on specific T cell subsets, Clin Exp Immunol, vol.166, pp.103-109, 2011.

A. Pallier, S. Hillion, R. Danger, M. Giral, M. Racape et al., Patients with drug-free long-term graft function display increased numbers of peripheral B cells with a memory and inhibitory phenotype, Kidney Int, vol.78, pp.503-513, 2010.

A. Panigrahi, J. A. Siddiqui, A. Rai, A. Margoob, A. Khaira et al., Allosensitization to HLA and MICA is an important measure of renal graft outcome, Clin Transpl, pp.211-217, 2007.

M. Pascual, T. Theruvath, T. Kawai, N. Tolkoff-rubin, and A. B. Cosimi, Strategies to improve long-term outcomes after renal transplantation, N Engl J Med, vol.346, pp.580-590, 2002.

J. P. Pearl, J. Parris, D. A. Hale, S. C. Hoffmann, W. B. Bernstein et al., Immunocompetent T-cells with a memorylike phenotype are the dominant cell type following antibody-mediated T-cell depletion, Am J Transplant, vol.5, pp.465-474, 2005.

E. Pedagogos, T. D. Hewitson, R. G. Walker, K. M. Nicholis, and G. J. Becker, Myofibroblast involvement in chronic transplant rejection, Transplantation, vol.64, pp.1192-1197, 1997.

, Effector Mechanisms of Rejection Cite this article as Cold Spring Harb Perspect Med, vol.3, p.15461, 2013.

R. Pei, J. H. Lee, N. J. Shih, M. Chen, and P. I. Terasaki, Single human leukocyte antigen flow cytometry beads for accurate identification of human leukocyte antigen antibody specificities, Transplantation, vol.75, pp.43-49, 2003.

O. Perrella, C. Sbreglia, G. Arenga, A. Perrella, A. Ferrara et al., Acute rejection after liver transplantation: Is there a specific immunological pattern?, Transplant Proc, vol.38, pp.3594-3596, 2006.

H. L. Pilmore, D. M. Painter, G. A. Bishop, G. W. Mccaughan, and J. M. Eris, Early up-regulation of macrophages and myofibroblasts: A new marker for development of chronic renal allograft rejection, Transplantation, vol.69, pp.2658-2662, 2000.

J. A. Pons, B. Revilla-nuin, A. Baroja-mazo, P. Ramirez, L. Martinez-alarcon et al., FoxP3 in peripheral blood is associated with operational tolerance in liver transplant patients during immunosuppression withdrawal, Transplantation, vol.86, pp.1370-1378, 2008.

F. K. Port, D. M. Dykstra, R. M. Merion, and R. A. Wolfe, Organ donation and transplantation trends in the USA, Am J Transplant, vol.4, pp.7-12, 2003.

A. M. Posselt, F. Vincenti, M. Bedolli, M. Lantz, J. P. Roberts et al., CD69 expression on peripheral CD8 T cells correlates with acute rejection in renal transplant recipients, Transplantation, vol.76, pp.190-195, 2003.

J. Pratschke, D. Stauch, and K. Kotsch, Role of NK and NKT cells in solid organ transplantation, Transpl Int, vol.22, pp.859-868, 2009.

F. Qi, A. Adair, D. Ferenbach, D. G. Vass, K. J. Mylonas et al., Depletion of cells of monocyte lineage prevents loss of renal microvasculature in murine kidney transplantation, Transplantation, vol.86, pp.1267-1274, 2008.

L. C. Racusen, K. Solez, R. B. Colvin, S. M. Bonsib, M. C. Castro et al., The Banff 97 working classification of renal allograft pathology, Kidney Int, vol.55, pp.713-723, 1999.

L. C. Racusen, R. B. Colvin, K. Solez, M. J. Mihatsch, P. F. Halloran et al., Antibody-mediated rejection criteria-An addition to the Banff 97 classification of renal allograft rejection, Am J Transplant, vol.3, pp.708-714, 2003.

H. Raedler, M. B. Vieyra, S. Leisman, P. Lakhani, W. Kwan et al., Anti-complement component C5 mAb synergizes with CTLA4Ig to inhibit alloreactive T cells and prolong cardiac allograft survival in mice, Am J Transplant, vol.11, pp.1397-1406, 2011.

U. Raffetseder, T. Rauen, S. Djudjaj, M. Kretzler, A. En-nia et al., Differential regulation of chemokine CCL5 expression in monocytes/macrophages and renal cells by Y-box protein-1, Kidney Int, vol.75, pp.185-196, 2009.

A. M. Ramirez, Z. Shen, J. D. Ritzenthaler, and R. J. , Myofibroblast transdifferentiation in obliterative bronchiolitis: TGF-b signaling through smad3-dependent and independent pathways, Am J Transplant, vol.6, pp.2080-2088, 2006.

M. Ramsperger-gleixner, B. M. Spriewald, R. Tandler, M. Kondruweit, K. Amann et al., Increased transcript levels of TNF-a, TGF-b, and granzyme B in endomyocardial biopsies correlate with allograft rejection, Exp Clin Transplant, vol.9, pp.387-392, 2011.

L. M. Rebellato, M. Ozawa, K. M. Verbanac, P. Catrou, C. E. Haisch et al., Clinical and anti-HLA antibody profile of nine renal transplant recipients with failed grafts: Donor-specific and non-donor-specific antibody development, Clin Transpl, pp.241-253, 2006.

H. Regele, G. A. Bohmig, A. Habicht, D. Gollowitzer, M. Schillinger et al., Capillary deposition of complement split product C4d in renal allografts is associated with basement membrane injury in peritubular and glomerular capillaries: A contribution of humoral immunity to chronic allograft rejection, J Am Soc Nephrol, vol.13, pp.2371-2380, 2002.

J. P. Ridge, D. Rosa, F. Matzinger, and P. , A conditioned dendritic cell can be a temporal bridge between a CD4 þ Thelper and a T-killer cell, Nature, vol.393, pp.474-478, 1998.

H. Ro, Y. H. Hwang, H. Kim, J. C. Jeong, H. Lee et al., Association of polymorphisms of interleukin-8, CXCR1, CXCR2, and selectin with allograft outcomes in kidney transplantation, Transplantation, vol.91, pp.57-64, 2011.

P. R. Rogers, C. Dubey, and S. L. Swain, Qualitative changes accompany memory T cell generation: Faster, more effective responses at lower doses of antigen, J Immunol, vol.164, pp.2338-2346, 2000.

M. C. Roos-van-groningen, E. M. Scholten, P. M. Lelieveld, A. T. Rowshani, H. J. Baelde et al., Molecular comparison of calcineurin inhibitor-induced fibrogenic responses in protocol renal transplant biopsies, J Am Soc Nephrol, vol.17, pp.881-888, 2006.

J. M. Rosenblum, N. Shimoda, A. D. Schenk, H. Zhang, D. D. Kish et al., CXC chemokine ligand CXCL9 and CXCL10 are antagonistic costimulation molecules during the priming of alloreactive T cell effectors, J Immunol, vol.184, pp.3450-3460, 2010.

M. Rossini, B. Cheunsuchon, E. Donnert, L. J. Ma, J. W. Thomas et al., Immunolocalization of fibroblast growth factor-1 (FGF-1), its receptor (FGFR-1), and fibroblast-specific protein-1 (FSP-1) in inflammatory renal disease, Kidney Int, vol.68, pp.2621-2628, 2005.

M. Rotondi, A. Rosati, A. Buonamano, L. Lasagni, E. Lazzeri et al., High pretransplant serum levels of CXCL10/ IP-10 are related to increased risk of renal allograft failure, Am J Transplant, vol.4, pp.1466-1474, 2004.

M. Rotondi, G. S. Netti, E. Lazzeri, G. Stallone, E. Bertoni et al., High pretransplant serum levels of CXCL9 are associated with increased risk of acute rejection and graft failure in kidney graft recipients, Transpl Int, vol.23, pp.465-475, 2010.

P. Sagoo, E. Perucha, B. Sawitzki, S. Tomiuk, D. A. Stephens et al., Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans, J Clin Invest, vol.120, pp.1848-1861, 2010.

P. Sagoo, N. Ali, G. Garg, F. O. Nestle, R. I. Lechler et al., Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells, Sci Transl Med, vol.3, pp.83-125, 2011.

A. D. Salama, K. L. Womer, and M. H. Sayegh, Clinical transplantation tolerance: Many rivers to cross, J Immunol, vol.178, pp.5419-5423, 2007.

F. Sallusto, D. Lenig, R. Forster, M. Lipp, and A. Lanzavecchia, Two subsets of memory T lymphocytes with distinct homing potentials and effector functions, Nature, vol.401, pp.708-712, 1999.

N. J. Sarma, V. Tiriveedhi, N. Angaswamy, and T. Mohanakumar, Role of antibodies to self-antigens in chronic allograft rejection: Potential mechanism and therapeutic implications, Hum Immunol, vol.10, p.10, 2012.

S. Schaub, P. Nickerson, D. Rush, M. Mayr, C. Hess et al., Urinary CXCL9 and CXCL10 levels correlate with the extent of subclinical tubulitis, Am J Transplant, vol.9, pp.1347-1353, 2009.

K. S. Schluns, W. C. Kieper, J. Sc, and L. Lefrancois, Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo, Nat Immunol, vol.1, pp.426-432, 2000.

K. O. Schowengerdt, F. J. Fricker, K. S. Bahjat, and S. T. Kuntz, Increased expression of the lymphocyte early activation marker CD69 in peripheral blood correlates with histologic evidence of cardiac allograft rejection, Transplantation, vol.69, pp.2102-2107, 2000.

M. Seiler, I. Brabcova, O. Viklicky, P. Hribova, C. Rosenberger et al., Heightened expression of the cytotoxicity receptor NKG2D correlates with acute and chronic nephropathy after kidney transplantation, Am J Transplant, vol.7, pp.423-433, 2007.

K. V. Shenoy, C. Solomides, F. Cordova, T. J. Rogers, D. Ciccolella et al., Low CD4/CD8 ratio in bronchus-associated lymphoid tissue is associated with lung allograft rejection, J Transplant, p.928081, 2012.

E. M. Shevach, Mechanisms of FoxP3 þ Tregulatory cellmediated suppression, Immunity, vol.30, pp.636-645, 2009.

G. T. Shin, S. J. Kim, T. S. Lee, C. K. Oh, and H. Kim, Gene expression of perforin by peripheral blood lymphocytes as a marker of acute rejection, Nephron Clin Pract, vol.100, pp.63-70, 2005.

H. M. Silva, M. C. Takenaka, P. M. Moraes-vieira, S. M. Monteiro, M. O. Hernandez et al., Preserving the B-cell compartment favors operational tolerance in human renal transplantation, Mol Med, vol.18, pp.733-743, 2012.
URL : https://hal.archives-ouvertes.fr/hal-01959589

B. Sis, P. M. Campbell, T. Mueller, C. Hunter, S. M. Cockfield et al., Transplant glomerulopathy, late antibody-mediated rejection and the ABCD tetrad in kidney allograft biopsies for cause, Am J Transplant, vol.7, pp.1743-1752, 2007.

B. Sis, G. S. Jhangri, S. Bunnag, K. Allanach, B. Kaplan et al., Endothelial gene expression in kidney transplants with alloantibody indicates antibody-mediated damage despite lack of C4d staining, Am J Transplant, vol.9, pp.2312-2323, 2009.

C. Smith, J. J. Miles, and R. Khanna, Advances in direct T-cell alloreactivity: Function, avidity, biophysics and structure, Am J Transplant, vol.12, pp.15-26, 2012.

L. A. Smyth, O. B. Herrera, D. Golshayan, G. Lombardi, and R. I. Lechler, A novel pathway of antigen presentation by dendritic and endothelial cells: Implications for allorecognition and infectious diseases, Transplantation, vol.82, pp.15-18, 2006.

K. Solez, F. Vincenti, and R. S. Filo, Histopathologic findings from 2-year protocol biopsies from a U.S. multicenter kidney transplant trial comparing tarolimus versus cyclosporine: A report of the FK506 Kidney Transplant Study Group, Transplantation, vol.66, pp.1736-1740, 1998.

K. Solez, R. B. Colvin, L. C. Racusen, B. Sis, P. F. Halloran et al., Banff '05 meeting report: Differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy, Am J Transplant, vol.7, pp.518-526, 2007.

K. Solez, R. B. Colvin, L. C. Racusen, M. Haas, B. Sis et al., Banff 07 classification of renal allograft pathology: Updates and future directions, Am J Transplant, vol.8, pp.753-760, 2008.

M. Sommer, J. Gerth, G. Stein, and G. Wolf, Transdifferentiation of endothelial and renal tubular epithelial cells into myofibroblast-like cells under in vitro conditions: A morphological analysis, Cells Tissues Organs, vol.180, pp.204-214, 2005.

C. Sorrentino, A. Scarinci, D. 'antuono, T. Piccirilli, M. et al., Endomyocardial infiltration by B and NK cells foreshadows the recurrence of cardiac allograft rejection, J Pathol, vol.209, pp.400-410, 2006.

S. Sumitran-holgersson, Relevance of MICA and other non-HLA antibodies in clinical transplantation, Curr Opin Immunol, vol.20, pp.607-613, 2008.

S. Sumitran-holgersson, H. E. Wilczek, J. Holgersson, and K. Soderstrom, Identification of the nonclassical HLA molecules, mica, as targets for humoral immunity associated with irreversible rejection of kidney allografts, Transplantation, vol.74, pp.268-277, 2002.

A. M. Summers, B. M. Coupes, M. F. Brennan, S. A. Ralph, C. D. Short et al., VEGF-460 genotype plays an important role in progression to chronic kidney disease stage 5, Nephrol Dial Transplant, vol.20, pp.2427-2432, 2005.

H. J. Sun, T. Zhou, Y. Wang, Y. W. Fu, Y. P. Jiang et al., Macrophages and T lymphocytes are the predominant cells in intimal arteritis of resected renal allografts undergoing acute rejection, Transpl Immunol, vol.25, pp.42-48, 2011.

M. Surquin, L. Moine, A. Flamand, V. Rombaut, K. Demoor et al., IL-4 deficiency prevents eosinophilic rejection and uncovers a role for neutrophils in the rejection of MHC class II disparate skin grafts, Transplantation, vol.80, pp.1485-1492, 2005.

C. Taflin, B. Favier, J. Baudhuin, A. Savenay, P. Hemon et al., Human endothelial cells generate Th17 and regulatory T cells under inflammatory conditions, Proc Natl Acad Sci, vol.108, pp.2891-2896, 2011.

C. Taflin, D. Charron, D. Glotz, and N. Mooney, Regulation of the CD4 þ T cell allo-immune response by endothelial cells, Hum Immunol, vol.16, p.16, 2012.

M. Takeiri, M. Tachibana, A. Kaneda, A. Ito, Y. Ishikawa et al., Inhibition of macrophage activation and suppression of graft rejection by DTCM-glutarimide, a novel Effector Mechanisms of Rejection Cite this article as Cold Spring, Harb Perspect Med, vol.3, pp.879-888, 2011.

K. Tanaka, K. Ozawa, S. Teramukai, Y. Takada, H. Egawa et al., Classification of human liver transplant recipients by their preoperative CD8 þ T cell subpopulation and its relation to outcome, Liver Transpl, vol.12, pp.792-800, 2006.

R. R. Tatapudi, T. Muthukumar, D. Dadhania, R. Ding, B. Li et al., Noninvasive detection of renal allograft inflammation by measurements of mRNA for IP-10 and CXCR3 in urine, Kidney Int, vol.65, pp.2390-2397, 2004.

P. I. Terasaki, Humoral theory of transplantation, Am J Transplant, vol.3, pp.665-673, 2003.

P. I. Terasaki and J. Cai, Humoral theory of transplantation: Further evidence, Curr Opin Immunol, vol.17, pp.541-545, 2005.

P. I. Terasaki and M. Ozawa, Predicting kidney graft failure by HLA antibodies: A prospective trial, Am J Transplant, vol.4, pp.438-443, 2004.

O. Thaunat and A. Nicoletti, Lymphoid neogenesis in chronic rejection, Curr Opin Organ Transplant, vol.13, pp.16-19, 2008.

O. Thaunat, A. C. Field, J. Dai, L. Louedec, N. Patey et al., Lymphoid neogenesis in chronic rejection: Evidence for a local humoral alloimmune response, Proc Natl Acad Sci, vol.102, pp.14723-14728, 2005.

O. Thaunat, N. Patey, E. Morelon, J. B. Michel, and A. Nicoletti, Lymphoid neogenesis in chronic rejection: The murderer is in the house, Curr Opin Immunol, vol.18, pp.576-579, 2006.

O. Thaunat, N. Patey, C. Gautreau, S. Lechaton, V. Fremeauxbacchi et al., B cell survival in intragraft tertiary lymphoid organs after rituximab therapy, Transplantation, vol.85, pp.1648-1653, 2008.

O. Thaunat, S. Graff-dubois, S. Brouard, C. Gautreau, A. Varthaman et al., Immune responses elicited in tertiary lymphoid tissues display distinctive features, PLoS ONE, vol.5, p.11398, 2010.

O. Thaunat, S. Graff-dubois, N. Fabien, A. Duthey, V. Attuilaudenis et al., A stepwise breakdown of B-cell tolerance occurs within renal allografts during chronic rejection, Kidney Int, vol.81, pp.207-219, 2012.

G. Tyden, H. Genberg, J. Tollemar, H. Ekberg, N. H. Persson et al., A randomized, doubleblind, placebo-controlled, study of single-dose rituximab as induction in renal transplantation, Transplantation, vol.87, pp.1325-1329, 2009.

R. Uppaluri, K. C. Sheehan, L. Wang, J. D. Bui, J. J. Brotman et al., Prolongation of cardiac and islet allograft survival by a blocking hamster anti-mouse CXCR3 monoclonal antibody, Transplantation, vol.86, pp.137-147, 2008.

A. Valujskikh, B. Pantenburg, and P. S. Heeger, Primed allospecific T cells prevent the effects of costimulatory blockade on prolonged cardiac allograft survival in mice, Am J Transplant, vol.2, pp.501-509, 2002.

W. Van-der-touw, B. Burrell, G. Lal, and J. S. Bromberg, NK cells are required for costimulatory blockade induced tolerance to vascularized allografts, Transplantation, vol.20, p.20, 2012.

H. Veiga-fernandes, U. Walter, C. Bourgeois, A. Mclean, and B. Rocha, Response of naive and memory CD8 þ T cells to antigen stimulation in vivo, Nat Immunol, vol.1, pp.47-53, 2000.

Y. Wang, H. Dai, Z. Liu, X. Cheng, G. Tellides et al., Neutralizing IL-7 promotes long-term allograft survival induced by CD40/CD40L costimulatory blockade, Am J Transplant, vol.6, pp.2851-2860, 2006.

S. Wang, J. Li, A. Xie, G. Wang, N. Xia et al., Dynamic changes in Th1, Th17, and FoxP3 þ T cells in patients with acute cellular rejection after cardiac transplantation, Clin Transplant, vol.25, pp.177-186, 2011.

B. A. Wasowska, Z. Qian, D. L. Cangello, E. Behrens, K. Van-tran et al., Passive transfer of alloantibodies restores acute cardiac rejection in IgKO mice, Transplantation, vol.71, pp.727-736, 2001.

D. I. Won, H. D. Jeong, Y. L. Kim, and J. S. Suh, Simultaneous detection of antibody binding and cytotoxicity in flow cytometry crossmatch for renal transplantation, Cytometry B Clin Cytom, vol.70, pp.82-90, 2006.

Z. Wu, S. J. Bensinger, J. Zhang, C. Chen, X. Yuan et al., Homeostatic proliferation is a barrier to transplantation tolerance, Nat Med, vol.10, pp.87-92, 2004.

T. Wu, G. Bond, D. Martin, M. A. Nalesnik, A. J. Demetris et al., Histopathologic characteristics of human intestine allograft acute rejection in patients pretreated with thymoglobulin or alemtuzumab, Am J Gastroenterol, vol.101, pp.1617-1624, 2006.

T. A. Wynn, Cellular and molecular mechanisms of fibrosis, J Pathol, vol.214, pp.199-210, 2008.

H. Xu, X. Zhang, R. B. Mannon, and A. D. Kirk, Platelet-derived or soluble CD154 induces vascularized allograft rejection independent of cell-bound CD154, J Clin Invest, vol.116, pp.769-774, 2006.

J. M. Yabu, J. P. Higgins, G. Chen, F. Sequeira, S. Busque et al., C1q-fixing human leukocyte antigen antibodies are specific for predicting transplant glomerulopathy and late graft failure after kidney transplantation, Transplantation, vol.91, pp.342-347, 2011.

A. Yamada, A. D. Salama, M. Sho, N. Najafian, T. Ito et al., CD70 signaling is critical for CD28-independent CD8, 2005.

, T cell-mediated alloimmune responses in vivo, J Immunol, vol.174, pp.1357-1364

W. S. Yang, N. J. Han, C. S. Kim, H. Ahn, S. K. Lee et al., STAT1-independent down-regulation of interferon-g-induced class II transactivator and HLA-DR expression by transforming growth factor b-1 in human glomerular endothelial cells, Nephron Exp Nephrol, vol.100, pp.124-131, 2005.

S. Yoo, E. Y. Lee, K. H. Huh, M. S. Kim, Y. S. Kim et al., Role of plasma exchange in ABO-incompatible kidney transplantation, Ann Lab Med, vol.32, pp.283-288, 2012.

X. Yuan, V. M. Dong, A. J. Coito, A. M. Waaga, A. D. Salama et al., A novel CD154 monoclonal antibody in acute and chronic rat vascularized cardiac allograft rejection, Transplantation, vol.73, pp.1736-1742, 2002.

X. Yuan, J. Paez-cortez, I. Schmitt-knosalla, D. 'addio, F. Mfarrej et al., A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy, J Exp Med, vol.205, pp.3133-3144, 2008.

X. Yuan, M. J. Ansari, D. 'addio, F. Paez-cortez, J. Schmitt et al., Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells, Proc Natl Acad Sci, vol.106, pp.10734-10739, 2009.

M. N. Zafar, P. I. Terasaki, S. A. Naqvi, and S. A. Rizvi, Non-HLA antibodies after rejection of HLA identical kidney transplants, Clin Transpl, pp.421-426, 2006.

V. Zarkhin, G. Chalasani, and M. M. Sarwal, The yin and yang of B cells in graft rejection and tolerance, Transplant Rev (Orlando), vol.24, pp.67-78, 2010.

Y. Zhai, L. Meng, F. Gao, R. W. Busuttil, and J. W. Kupiec-weglinski, Allograft rejection by primed/memory CD8 þ T cells is CD154 blockade resistant: Therapeutic implications for sensitized transplant recipients, J Immunol, vol.169, pp.4667-4673, 2002.

Y. Zhai, X. D. Shen, W. W. Hancock, F. Gao, B. Qiao et al., CXCR3 Immunol, vol.176, pp.6313-6322, 2006.

Z. X. Zhang, S. Wang, X. Huang, W. P. Min, H. Sun et al., NK cells induce apoptosis in tubular epithelial cells and contribute to renal ischemiareperfusion injury, J Immunol, vol.181, pp.7489-7498, 2008.

W. Zhou, C. A. Farrar, K. Abe, J. R. Pratt, J. E. Marsh et al., Predominant role for C5b-9 in renal ischemia/reperfusion injury, J Clin Invest, vol.105, pp.1363-1371, 2000.

M. Zhuo, M. Fujiki, M. Wang, K. Piard-ruster, L. E. Wai et al., Identification of the rat NKG2D ligands, RAE1L and RRLT, and their role in allograft rejection, Eur J Immunol, vol.40, pp.1748-1757, 2010.

Y. Zou, P. Stastny, C. Susal, B. Dohler, and G. Opelz, Antibodies against MICA antigens and kidney-transplant rejection, N Engl J Med, vol.357, pp.1293-1300, 2007.