Skip to Main content Skip to Navigation
Journal articles

Effector Mechanisms of Rejection

Abstract : Organ transplantation appears today to be the best alternative to replace the loss of vital organs induced by various diseases. Transplants can, however, also be rejected by the recipient. In this review, we provide an overview of the mechanisms and the cells/molecules involved in acute and chronic rejections. T cells and B cells mainly control the antigen-specific rejection and act either as effector, regulatory, or memory cells. On the other hand, nonspecific cells such as endothelial cells, NK cells, macrophages, or polymorphonuclear cells are also crucial actors of transplant rejection. Last, beyond cells, the high contribution of antibodies, chemokines, and complement molecules in graft rejection is discussed in this article. The understanding of the different components involved in graft rejection is essential as some of them are used in the clinic as biomarkers to detect and quantify the level of rejection.
Document type :
Journal articles
Complete list of metadata

Cited literature [268 references]  Display  Hide  Download
Contributor : Sylvie Le Bihan Connect in order to contact the contributor
Submitted on : Wednesday, June 26, 2019 - 2:03:56 PM
Last modification on : Monday, November 18, 2019 - 11:22:07 AM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document




Aurélie Moreau, Emilie Varey, Ignacio Anegon, Maria-Cristina Cuturi. Effector Mechanisms of Rejection. Cold Spring Harbor Perspectives in Medicine, Cold Spring Harbor Laboratory Press, 2013, 3 (11), pp.a015461-a015461. ⟨10.1101/cshperspect.a015461⟩. ⟨inserm-02166030⟩



Record views