C. Arsac, C. Raymond, N. Martin-moutot, B. Dargent, F. Couraud et al., Immunoassays fail to detect antibodies against neuronal calcium channels in amyotrophic lateral sclerosis serum, Ann. Neurol, vol.40, pp.695-700, 1996.

L. Birnbaumer, K. P. Campbell, W. A. Catterall, M. M. Harpold, F. Hofmann et al., The naming of voltage-gated calcium channels, Neuron, vol.13, pp.505-506, 1994.

N. Charvin, C. Leveque, D. Walker, F. Berton, C. Raymond et al., Direct interaction of the calcium channel sensor protein synaptotagmin I with a cytoplasmic domain of the 1A subunit of the P/Q-type calcium channel, Eur. molec. Biol. Org. J, vol.16, pp.4591-4596, 1997.

P. D. Clouston, C. B. Saper, T. Arbizu, I. Johnston, B. Lang et al., Paraneoplastic cerebellar degeneration, Neurology, vol.42, pp.1944-1950, 1992.

J. Dalmau, H. M. Furneaux, R. J. Gralla, M. G. Kris, and J. B. Posner, Detection of the anti-Hu antibody in the serum of patients with small cell lung cancer-a quantitative western blot analysis, Ann. Neurol, vol.27, pp.544-552, 1990.

C. David, M. Solimena, D. Camilli, and P. , Autoimmunity in Stiff-Man syndrome with breast cancer is targeted to the C-terminal region of human amphiphysin, a protein similar to the yeast proteins, Rvs167 and Rvs161, Fedn Eur. biochem. Socs Lett, vol.351, pp.73-79, 1994.

N. C. Day, S. J. Wood, P. G. Ince, S. G. Volsen, W. Smith et al., Differential localization of voltage-dependent calcium channel 1 subunits at the human and rat neuromuscular junction, J. Neurosci, vol.17, pp.6226-6235, 1997.

M. De-waard, D. R. Witcher, M. Pragnell, H. Liu, and K. P. Campbell, Properties of the 1 -anchoring site in voltage-dependent Ca 2+ channels, J. biol. Chem, vol.270, p.64, 1995.

M. De-waard, C. A. Gurnett, and K. P. Campbell, Structural and functional diversity of voltage-activated calcium channels, Ion Channels, pp.41-87, 1996.

O. El-far, B. Marquèze, C. Leveque, N. Martin-moutô-t, B. Lang et al., Antigens associated with N-and L-type calcium channels in Lambert-Eaton myasthenic syndrome, J. Neurochem, vol.64, pp.1696-1702, 1995.

V. Flockerzi, H. Oeken, F. Hofmann, D. Pelzer, A. Cavalie et al., Purified dihydropyridinebinding site from skeletal muscle t-tubules is a functional calcium channel, Nature, vol.323, pp.66-68, 1986.
DOI : 10.1038/323066a0

H. Fukunaga, A. G. Engel, B. Lang, J. Newsom-davis, and A. Vincent, Passive transfer of Lambert-Eaton myasthenic syndrome with IgG from man to mouse depletes the presynaptic membrane active zones, Proc. natn. Acad. Sci. U.S.A, vol.80, pp.7636-7640, 1983.

K. D. Garcia and K. G. Beam, Reduction of calcium currents by Lambert-Eaton syndrome sera: motoneurons are preferentially affected, and l-type currents are spared, J. Neurosci, vol.16, pp.4903-4913, 1996.

R. K. Hajela and W. D. Atchison, The proteins synaptotagmin and syntaxin are not general targets of Lambert-Eaton myasthenic syndrome autoantibody, J. Neurochem, vol.64, pp.1245-1251, 1995.

C. Raymond,

Y. I. Kim, J. M. Longacher, and M. P. Viglione, Agatoxin IVA blocks evoked quantal transmitter release at the mammalian neuromuscular junction, Molec. Biol. Cell, vol.4, 1993.

Y. I. Kim and E. Neher, IgG from patients with Lambert-Eaton syndrome blocks voltage-dependent calcium channels, Science, vol.239, pp.405-408, 1988.
DOI : 10.1126/science.2447652

E. H. Lambert, L. M. Eaton, and E. D. Rooke, Defect of neuromuscular conduction associated with malignant neoplasm, Am. J. Physiol, vol.187, pp.612-613, 1956.

V. A. Lennon and E. H. Lambert, Autoantibodies bind solubilized calcium--conotoxin complexes from small cell lung carcinoma: a diagnostic aid for Lambert-Eaton myasthenic syndrome, Mayo Clin. Proc, vol.64, pp.1498-1504, 1989.

C. Lévêque, T. Hoshino, P. David, Y. Shoji-kasai, K. Leys et al., The synaptic vesicle protein synaptotagmin associates with calcium channels and is a putative Lambert-Eaton myasthenic syndrome antigen, Proc. natn. Acad. Sci. U.S.A, vol.89, pp.3625-3629, 1992.

K. Leys, B. Lang, and J. Newsom-davis, Calcium channel autoantibodies in the Lambert-Eaton myasthenic syndrome, Ann. Neurol, vol.29, pp.307-314, 1991.

H. Liu, M. De-waard, V. E. Scott, C. A. Gurnett, V. A. Lennon et al., Identification of three subunits of the high affinity omega-conotoxin MVIIC-sensitive Ca 2+ channel, J. biol. Chem, vol.271, pp.13804-13810, 1996.

V. Magnelli, C. Grassi, E. Parlatore, E. Sher, and E. Carbone, Down-regulation of non-L-, non-N-type (Q-like) Ca 2+ channels by Lambert-Eaton myasthenic syndrome (LEMS) antibodies in rat insulinoma RINm5F cells, Fedn Eur. biochem. Socs Lett, vol.387, pp.47-52, 1996.

N. Martin-moutot, C. Leveque, K. Sato, R. Kato, M. Takahashi et al., Properties of omega conotoxin MVIIC receptors associated with alpha 1A calcium channel subunits in rat brain, Fedn Eur. biochem. Socs Lett, vol.366, pp.21-25, 1995.

N. Martin-moutot, N. Charvin, C. Leveque, K. Sato, T. Nishiki et al., Interaction of SNARE complexes with P/Q-type calcium channels in rat cerebellar synaptosomes, J. biol. Chem, vol.271, pp.6567-6570, 1996.

M. Motomura, I. Johnston, B. Lang, A. Vincent, and J. Newsom-davis, An improved diagnostic assay for Lambert-Eaton myasthenic syndrome, J. Neurol. Neurosurg. Psychiat, vol.58, pp.85-87, 1995.
DOI : 10.1136/jnnp.58.1.85
URL : https://jnnp.bmj.com/content/58/1/85.full.pdf

J. H. O'neill, N. M. Murray, and J. Newsom-davis, The Lambert-Eaton myasthenic syndrome, Brain, vol.111, pp.577-596, 1988.

C. Peers, B. Lang, J. Newsom-davis, and D. W. Wray, Selective action of myasthenic syndrome antibodies on calcium channels in a rodent neuroblastoma glioma cell line, J. Physiol, vol.421, pp.293-308, 1990.

A. Roberts, S. Perera, B. Lang, A. Vincent, and J. Newsom-davis, Paraneoplastic myasthenic syndrome IgG inhibits 45, 1985.
DOI : 10.1038/317737a0

, Ca 2+ flux in a human small cell carcinoma line, Nature, vol.317, pp.737-739

M. R. Rosenfeld, E. Wong, J. Dalmau, G. Manley, J. B. Posner et al., Cloning and characterization of a Lambert-Eaton myasthenic syndrome antigen, Ann. Neurol, vol.33, pp.113-120, 1993.

V. E. Scott, M. De-waard, H. Liu, C. A. Gurnett, D. P. Venzke et al., Beta subunit heterogeneity in N-type Ca 2+ channels, J. biol. Chem, vol.271, pp.3207-3212, 1996.
DOI : 10.1074/jbc.271.6.3207
URL : http://www.jbc.org/content/271/6/3207.full.pdf

E. Sher, C. Gotti, N. Canal, C. Scopetta, A. Evoli et al., Specificity of calcium channel autoantibodies in Lambert-Eaton myasthenic syndrome, Lancet, vol.2, pp.640-643, 1989.

A. Suenaga, S. Shirabe, T. Nakamura, M. Motomura, M. Tsujihata et al., Specificity of autoantibodies reacting with omega-conotoxin MVIIC-sensitive calcium channel in Lambert-Eaton myasthenic syndrome, Muscle Nerve, vol.19, pp.1166-1168, 1996.

T. Takahashi and A. Momiyama, Different types of calcium channels mediate central synaptic transmission, Nature, vol.366, pp.156-158, 1993.

M. Takamori, T. Hamada, K. Komai, M. Takahashi, and A. Yoshida, Synaptotagmin can cause an immune-mediated model of Lambert-Eaton myasthenic syndrome in rats, Ann. Neurol, vol.35, pp.74-80, 1994.

M. Takamori, M. Takahashi, Y. Yasukawa, K. Iwasa, Y. Nemoto et al., Antibodies to recombinant synaptotagmin and calcium channel subtypes in Lambert-Eaton myasthenic syndrome, J. neurol. Sci, vol.133, pp.95-101, 1995.

O. D. Uchitel, D. A. Protti, V. Sanchez, B. D. Cherksey, M. Sugimori et al., P-type voltage-dependent calcium channel mediates presynaptic calcium influx and transmitter release in mammalian synapses, Proc. natn. Acad. Sci. U.S.A, vol.89, pp.3330-3333, 1992.

M. P. Viglione, T. J. Oshaughnessy, and Y. I. Kim, Inhibition of calcium currents and exocytosis by Lambert-Eaton syndrome antibodies in human lung cancer cells, J. Physiol, vol.488, pp.303-317, 1995.

D. Wheeler, A. Randall, and R. Tsien, Roles of N-type and Q-type Ca 2+ channels in supporting hippocampal synaptic transmission, Science, vol.264, pp.107-111, 1994.

D. R. Witcher, M. De-waard, J. Sakamoto, C. Franzini-armstrong, M. Pragnell et al., Subunit identification and reconstitution of the N-type Ca 2+ channel complex purified from brain, Science, vol.261, pp.486-489, 1993.