S. S. Sikandar, K. T. Pate, S. Anderson, D. Dizon, and R. A. Edwards, NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer, Cancer Res, vol.70, pp.1469-1478, 2010.

S. Fre, S. K. Pallavi, M. Huyghe, M. Lae, and K. P. Janssen, Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine, Proc Natl Acad Sci U S A, vol.106, pp.6309-6314, 2009.

M. Reedijk, S. Odorcic, H. Zhang, R. Chetty, and C. Tennert, Activation of Notch signaling in human colon adenocarcinoma, Int J Oncol, vol.33, pp.1223-1229, 2008.

L. M. Veenendaal, O. Kranenburg, N. Smakman, A. Klomp, and I. H. Borel-rinkes, Differential Notch and TGFbeta signaling in primary colorectal tumors and their corresponding metastases, Cell Oncol, vol.30, pp.1-11, 2008.

D. Strooper, B. Annaert, W. Cupers, P. Saftig, P. Craessaerts et al., A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain, Nature, vol.398, pp.518-522, 1999.

S. Jarriault, C. Brou, F. Logeat, E. H. Schroeter, and R. Kopan, Signalling downstream of activated mammalian Notch, Nature, vol.377, pp.355-358, 1995.

S. Jarriault, L. Bail, O. Hirsinger, E. Pourquie, O. Logeat et al., Delta-1 activation of notch-1 signaling results in HES-1 transactivation, Mol Cell Biol, vol.18, pp.7423-7431, 1998.

S. Fre, M. Huyghe, P. Mourikis, S. Robine, and D. Louvard, Notch signals control the fate of immature progenitor cells in the intestine, Nature, vol.435, pp.964-968, 2005.

N. F. Shroyer, M. A. Helmrath, V. Y. Wang, B. Antalffy, and S. J. Henning, Intestine-specific ablation of mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasis, Gastroenterology, vol.132, pp.2478-2488, 2007.

W. Bossuyt, A. Kazanjian, D. Geest, N. Van-kelst, S. et al., Atonal homolog 1 is a tumor suppressor gene, PLoS Biol, vol.7, p.39, 2009.

C. C. Leow, M. S. Romero, S. Ross, P. Polakis, and W. Q. Gao, Hath1, downregulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells, Cancer Res, vol.64, pp.6050-6057, 2004.

A. Velcich, W. Yang, J. Heyer, A. Fragale, and C. Nicholas, Colorectal cancer in mice genetically deficient in the mucin Muc2, Science, vol.295, pp.1726-1729, 2002.

W. Yang, L. Bancroft, C. Nicholas, I. Lozonschi, and L. H. Augenlicht, Targeted inactivation of p27kip1 is sufficient for large and small intestinal tumorigenesis in the mouse, which can be augmented by a Western-style high-risk diet, Cancer Res, vol.63, pp.4990-4996, 2003.

. Fenoglio-preiser, Gastro-intestinal Pathology, an Atlas and Text, 3 rd Lippincott, 2008.

S. B. Ho, S. H. Itzkowitz, A. M. Friera, S. H. Jiang, and Y. S. Kim, Cell lineage markers in premalignant and malignant colonic mucosa, Gastroenterology, vol.97, pp.392-404, 1989.

J. Bara, E. Chastre, J. Mahiou, R. L. Singh, and M. E. Forgue-lafitte, Gastric M1 mucin, an early oncofetal marker of colon carcinogenesis, is encoded by the MUC5AC gene, Int J Cancer, vol.75, pp.767-773, 1998.

J. Bara, F. Loisillier, and P. Burtin, Antigens of gastric and intestinal mucous cells in human colonic tumours, Br J Cancer, vol.41, pp.209-221, 1980.

D. H. Kim, J. W. Kim, J. H. Cho, S. H. Baek, and S. Kakar, Expression of mucin core proteins, trefoil factors, APC and p21 in subsets of colorectal polyps and cancers suggests a distinct pathway of pathogenesis of mucinous carcinoma of the colorectum, Int J Oncol, vol.27, pp.957-964, 2005.

B. Kocer, A. Soran, S. Erdogan, M. Karabeyoglu, and O. Yildirim, Expression of MUC5AC in colorectal carcinoma and relationship with prognosis, Pathol Int, vol.52, pp.470-477, 2002.

B. Czernichow, P. Simon-assmann, M. Kedinger, C. Arnold, and M. Parache, Sucrase-isomaltase expression and enterocytic ultrastructure of human colorectal tumors, Int J Cancer, vol.44, pp.238-244, 1989.

I. Chantret, A. Barbat, E. Dussaulx, M. G. Brattain, and A. Zweibaum, Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: a survey of twenty cell lines, Cancer Res, vol.48, pp.1936-1942, 1988.

C. L. Laboisse, J. J. Maoret, N. Triadou, and C. Augeron, Restoration by polyethylene glycol of characteristics of intestinal differentiation in subpopulations of the human colonic adenocarcinoma cell line HT29, Cancer Res, vol.48, pp.2498-2504, 1988.

E. Grasset, M. Pinto, E. Dussaulx, A. Zweibaum, and J. F. Desjeux, Epithelial properties of human colonic carcinoma cell line Caco-2: electrical parameters, Am J Physiol, vol.247, pp.260-267, 1984.

C. Augeron and C. L. Laboisse, Emergence of permanently differentiated cell clones in a human colonic cancer cell line in culture after treatment with sodium butyrate, Cancer Res, vol.44, pp.3961-3969, 1984.

I. V. Pandrea, V. Carriere, A. Barbat, D. Cambier, and E. Dussaulx, Postmitotic differentiation of colon carcinoma caco-2 cells does not prevent reentry in the cell cycle and tumorigenicity, Exp Mol Pathol, vol.69, pp.37-45, 2000.

P. Blache, M. Van-de-wetering, I. Duluc, C. Domon, and P. Berta, SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes, J Cell Biol, vol.166, pp.37-47, 2004.
URL : https://hal.archives-ouvertes.fr/hal-00266987

L. F. Wang, R. Zhang, and X. Xie, Development of a high-throughput assay for screening of gamma-secretase inhibitor with endogenous human, mouse or Drosophila gamma-secretase, Molecules, vol.14, pp.3589-3599, 2009.

T. M. Yeung, S. C. Gandhi, and W. F. Bodmer, Hypoxia and lineage specification of cell line-derived colorectal cancer stem cells, Proc Natl Acad Sci, vol.108, pp.4382-4387, 2011.

S. Von-kleist, E. Chany, P. Burtin, M. King, and J. Fogh, Immunohistology of the antigenic pattern of a continuous cell line from a human colon tumor, J Natl Cancer Inst, vol.55, pp.555-560, 1975.

C. L. Laboisse, C. Augeron, and F. Potet, Growth and differentiation of human gastrointestinal adenocarcinoma stem cells in soft agarose, Cancer Res, vol.41, pp.310-315, 1981.

T. Quillard, J. Devalliere, M. Chatelais, F. Coulon, and C. Seveno, Notch2 signaling sensitizes endothelial cells to apoptosis by negatively regulating the key protective molecule survivin, PLoS One, vol.4, p.8244, 2009.

A. Jarry, L. Charrier, C. Bou-hanna, M. C. Devilder, and V. Crussaire, Position in cell cycle controls the sensitivity of colon cancer cells to nitric oxidedependent programmed cell death, Cancer Res, vol.64, pp.4227-4234, 2004.

A. Jarry, K. Bach-ngohou, D. Masson, T. Dejoie, and P. A. Lehur, Human colonic myocytes are involved in postischemic inflammation through ADAM17-dependent TNFalpha production, Br J Pharmacol, vol.147, pp.64-72, 2006.

K. Murata, M. Hattori, N. Hirai, Y. Shinozuka, and H. Hirata, Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1, Mol Cell Biol, vol.25, pp.4262-4271, 2005.

J. H. Van-es, M. E. Van-gijn, O. Riccio, M. Van-den-born, and M. Vooijs, Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells, Nature, vol.435, pp.959-963, 2005.

J. H. Van-es, N. De-geest, M. Van-de-born, H. Clevers, and B. A. Hassan, Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors, Nat Commun, vol.1, p.18, 2010.

A. Kazanjian, T. Noah, D. Brown, J. Burkart, and N. F. Shroyer, Atonal homolog 1 is required for growth and differentiation effects of notch/gamma-secretase inhibitors on normal and cancerous intestinal epithelial cells, Gastroenterology, vol.139, pp.911-916, 2010.

S. S. Rao, J. O'neil, C. D. Liberator, J. S. Hardwick, and X. Dai, Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells, Cancer Res, vol.69, pp.3060-3068, 2009.

O. Riccio, M. E. Van-gijn, A. C. Bezdek, L. Pellegrinet, and J. H. Van-es, Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2, EMBO Rep, vol.9, pp.377-383, 2008.

C. Deschenes, A. Vezina, J. F. Beaulieu, and N. Rivard, Role of p27(Kip1) in human intestinal cell differentiation, Gastroenterology, vol.120, pp.423-438, 2001.

G. Peignon, A. Durand, W. Cacheux, O. Ayrault, and B. Terris, Complex interplay between beta-catenin signalling and Notch effectors in intestinal tumorigenesis, Gut, vol.60, pp.166-176, 2011.
URL : https://hal.archives-ouvertes.fr/inserm-00553865

R. H. Stanley and . La, WHO Classification of Tumors: Pathology and Genetics of Tumors of Digestive System, 2000.