Identification of Tribbles-1 as a Novel Binding Partner of Foxp3 in Regulatory T Cells

Abstract : Background: TRIB1, aserine-threonine kinase-like molecule, is a biomarker of chronic antibody-mediated rejection. Results: TRIB1 is highly expressed in Tregs, where its expression correlates with Foxp3, a molecule with which it interacts directly. Conclusion: TRIB1 is a novel binding partner of Foxp3 in Tregs. Significance: TRIB1 may play a crucial role in Tregs in cooperation with Foxp3.
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Emilie Dugast, Endre Kiss-Toth, Louise Docherty, Richard Danger, Mélanie Chesneau, et al.. Identification of Tribbles-1 as a Novel Binding Partner of Foxp3 in Regulatory T Cells. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2013, 288 (14), pp.10051-10060. ⟨10.1074/jbc.M112.448654⟩. ⟨inserm-02165818⟩

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