The kinetics of rAAV integration in the liver, Nat Genet, vol.19, pp.13-15, 1998. ,
Sites of recombinant adeno-associated virus integration, Int J Oncol, vol.12, pp.805-810, 1998. ,
Isolation of recombinant adeno-associated virus vector-cellular DNA junctions from mouse liver, J Virol, vol.73, pp.5438-5447, 1999. ,
Chromosomal effects of adeno-associated virus vector integration, Nat Genet, vol.30, pp.147-148, 2002. ,
No evidence for tumorigenesis of AAV vectors in a large-scale study in mice, Mol Ther, vol.12, pp.299-306, 2005. ,
Analysis of tumors arising in male B6C3F1 mice with and without AAV vector delivery to liver, Mol Ther, vol.14, pp.34-44, 2006. ,
Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors, Gene Therapy, vol.8, pp.1343-1346, 2001. ,
AAV vector integration sites in mouse hepatocellular carcinoma, Science, vol.317, p.477, 2007. ,
Transient expression of genes delivered to newborn rat liver using recombinant adeno-associated virus 2/8 vectors, J Gene Med, vol.11, pp.689-696, 2009. ,
Purification, induction, and distribution of placental glutathione transferase: a new marker enzyme for preneoplastic cells in the rat chemical hepatocarcinogenesis, Proc Natl Acad Sci, vol.82, pp.3964-3968, 1985. ,
New principle for the analysis of chemical carcinogenesis, Nature, vol.263, pp.701-703, 1976. ,
Hepatic gene transfer in neonatal mice by adeno-associated virus serotype 8 vector, Hum Gene Ther, vol.23, pp.533-539, 2012. ,
The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation, Toxicol Appl Pharmacol, vol.235, pp.305-311, 2009. ,
Assessing the potential for AAV vector genotoxicity in a murine model, Blood, vol.117, pp.3311-3319, 2011. ,
Prevention of hepatocellular adenoma and correction of metabolic abnormalities in murine glycogen storage disease type Ia by gene therapy, Hepatology, vol.56, pp.1719-1729, 2012. ,
Adenovirus-associated virus vector-mediated gene transfer in hemophilia B, N Engl J Med, vol.365, pp.2357-2365, 2011. ,
AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage, Blood, vol.119, pp.957-966, 2012. ,
Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo, Gene Therapy, vol.10, pp.2112-2118, 2003. ,
Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer, Nat Med, vol.12, pp.585-591, 2006. ,
Optimal design of a single recombinant adeno-associated virus derived from serotypes 1 and 2 to achieve more tightly regulated transgene expression from nonhuman primate muscle, Mol Ther, vol.9, pp.410-418, 2004. ,
A transgenic mouse with beta-Galactosidase as a fetal liver self-antigen for immunotherapy studies, J Hepatol, vol.47, pp.396-403, 2007. ,
Highresolution insertion-site analysis by linear amplification-mediated PCR (LAM-PCR), Nat Methods, vol.4, pp.1051-1057, 2007. ,
Comprehensive genomic access to vector integration in clinical gene therapy, Nat Med, vol.15, pp.1431-1436, 2009. ,
Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy, Science, vol.326, pp.818-823, 2009. ,
Integration frequency and intermolecular recombination of rAAV vectors in nonhuman primate skeletal muscle and liver, Mol Ther, vol.20, pp.1177-1186, 2012. ,