C. H. Miao, R. O. Snyder, D. B. Schowalter, G. A. Patijn, B. Donahue et al., The kinetics of rAAV integration in the liver, Nat Genet, vol.19, pp.13-15, 1998.

E. D. Rivadeneira, N. C. Popescu, D. B. Zimonjic, G. S. Cheng, P. J. Nelson et al., Sites of recombinant adeno-associated virus integration, Int J Oncol, vol.12, pp.805-810, 1998.

H. Nakai, Y. Iwaki, M. A. Kay, and L. B. Couto, Isolation of recombinant adeno-associated virus vector-cellular DNA junctions from mouse liver, J Virol, vol.73, pp.5438-5447, 1999.

D. G. Miller, E. A. Rutledge, and D. W. Russell, Chromosomal effects of adeno-associated virus vector integration, Nat Genet, vol.30, pp.147-148, 2002.

P. Bell, L. Wang, C. Lebherz, D. B. Flieder, M. S. Bove et al., No evidence for tumorigenesis of AAV vectors in a large-scale study in mice, Mol Ther, vol.12, pp.299-306, 2005.

P. Bell, A. D. Moscioni, R. J. Mccarter, D. Wu, G. Gao et al., Analysis of tumors arising in male B6C3F1 mice with and without AAV vector delivery to liver, Mol Ther, vol.14, pp.34-44, 2006.

A. Donsante, C. Vogler, N. Muzyczka, J. M. Crawford, J. Barker et al., Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors, Gene Therapy, vol.8, pp.1343-1346, 2001.

A. Donsante, D. G. Miller, Y. Li, C. Vogler, E. M. Brunt et al., AAV vector integration sites in mouse hepatocellular carcinoma, Science, vol.317, p.477, 2007.

M. Flageul, A. D. Pichard, V. Nguyen, T. H. Nowrouzi, A. Schmidt et al., Transient expression of genes delivered to newborn rat liver using recombinant adeno-associated virus 2/8 vectors, J Gene Med, vol.11, pp.689-696, 2009.

K. Satoh, A. Kitahara, Y. Soma, Y. Inaba, I. Hatayama et al., Purification, induction, and distribution of placental glutathione transferase: a new marker enzyme for preneoplastic cells in the rat chemical hepatocarcinogenesis, Proc Natl Acad Sci, vol.82, pp.3964-3968, 1985.

D. Solt and E. Farber, New principle for the analysis of chemical carcinogenesis, Nature, vol.263, pp.701-703, 1976.

L. Wang, H. Wang, P. Bell, D. Mcmenamin, and J. M. Wilson, Hepatic gene transfer in neonatal mice by adeno-associated virus serotype 8 vector, Hum Gene Ther, vol.23, pp.533-539, 2012.

I. P. Pogribny, L. Muskhelishvili, V. P. Tryndyak, and F. A. Beland, The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation, Toxicol Appl Pharmacol, vol.235, pp.305-311, 2009.

H. Li, N. Malani, S. R. Hamilton, A. Schlachterman, G. Bussadori et al., Assessing the potential for AAV vector genotoxicity in a murine model, Blood, vol.117, pp.3311-3319, 2011.

Y. M. Lee, H. S. Jun, C. J. Pan, S. R. Lin, L. H. Wilson et al., Prevention of hepatocellular adenoma and correction of metabolic abnormalities in murine glycogen storage disease type Ia by gene therapy, Hepatology, vol.56, pp.1719-1729, 2012.

A. C. Nathwani, E. G. Tuddenham, S. Rangarajan, C. Rosales, J. Mcintosh et al., Adenovirus-associated virus vector-mediated gene transfer in hemophilia B, N Engl J Med, vol.365, pp.2357-2365, 2011.

C. Binny, J. Mcintosh, D. Peruta, M. Kymalainen, H. Tuddenham et al., AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage, Blood, vol.119, pp.957-966, 2012.

D. M. Mccarty, H. Fu, P. E. Monahan, C. E. Toulson, P. Naik et al., Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo, Gene Therapy, vol.10, pp.2112-2118, 2003.

B. D. Brown, M. A. Venneri, A. Zingale, S. Sergi, L. Naldini et al., Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer, Nat Med, vol.12, pp.585-591, 2006.

P. Chenuaud, T. Larcher, J. E. Rabinowitz, N. Provost, B. Joussemet et al., Optimal design of a single recombinant adeno-associated virus derived from serotypes 1 and 2 to achieve more tightly regulated transgene expression from nonhuman primate muscle, Mol Ther, vol.9, pp.410-418, 2004.

J. Cany, A. A. Pichard, V. , A. D. Ferry, N. Conchon et al., A transgenic mouse with beta-Galactosidase as a fetal liver self-antigen for immunotherapy studies, J Hepatol, vol.47, pp.396-403, 2007.

M. Schmidt, K. Schwarzwaelder, C. Bartholomae, K. Zaoui, C. Ball et al., Highresolution insertion-site analysis by linear amplification-mediated PCR (LAM-PCR), Nat Methods, vol.4, pp.1051-1057, 2007.

R. Gabriel, R. Eckenberg, A. Paruzynski, C. C. Bartholomae, A. Nowrouzi et al., Comprehensive genomic access to vector integration in clinical gene therapy, Nat Med, vol.15, pp.1431-1436, 2009.

N. Cartier, S. Hacein-bey-abina, C. C. Bartholomae, G. Veres, M. Schmidt et al., Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy, Science, vol.326, pp.818-823, 2009.

A. Nowrouzi, M. Penaud-budloo, C. Kaeppel, U. Appelt, L. Guiner et al., Integration frequency and intermolecular recombination of rAAV vectors in nonhuman primate skeletal muscle and liver, Mol Ther, vol.20, pp.1177-1186, 2012.