Geographic variations of multiple sclerosis in France, Brain, vol.133, pp.1889-99, 2010. ,
Multiple sclerosis, Lancet, vol.372, pp.1502-1519, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-00996686
Multiple sclerosis, J Clin Invest, vol.122, pp.1180-1188, 2012. ,
Multiple sclerosis, N Engl J Med, vol.343, pp.938-52, 2000. ,
Immunology of multiple sclerosis, Annu Rev Immunol, vol.23, pp.683-747, 2005. ,
,
, Rev Prat, vol.56, pp.1306-1318, 2006.
Is hypovitaminosis D one of the environmental risk factors for multiple sclerosis?, Brain, vol.133, pp.1869-88, 2010. ,
Vitamine D et auto-immunité. Deuxième partie : aspects cliniques, Rev Med Interne, vol.33, pp.87-93, 2012. ,
The genetics of multiple sclerosis: an up-to-date review, Immunol Rev, vol.248, pp.87-103, 2012. ,
Observation on attempts to produce acute disseminated encephalomyelitis in monkeys, J Exp Med, vol.58, pp.39-53, 1933. ,
Experimental models of multiple sclerosis, Rev Neurol (Paris), vol.163, pp.651-656, 2007. ,
Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction, J Exp Med, vol.192, pp.393-404, 2000. ,
Multiple sclerosis: T-cell receptor expression in distinct brain regions, Brain, vol.130, pp.2789-99, 2007. ,
Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells, Clin Immunol, vol.130, pp.133-177, 2009. ,
Frequency of circulating autoreactive T cells committed to myelin determinants in relapsing-remitting multiple sclerosis patients, Clin Immunol, vol.144, pp.117-143, 2012. ,
Autoimmune T cell responses in the central nervous system, Nat Rev Immunol, vol.9, pp.393-407, 2009. ,
Cytokines and effector T cell subsets causing autoimmune CNS disease, FEBS Letters, vol.585, pp.3747-57, 2011. ,
T cells in multiple sclerosis and experimental autoimmune encephalomyelitis, Clin Exp Immunol, vol.162, pp.1-11, 2010. ,
Th1 versus Th17: are T cell cytokines relevant in multiple sclerosis?, Biochim Biophys Acta, vol.1812, pp.246-51, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00652650
Exacerbations of multiple sclerosis in patients treated with gamma interferon, Lancet, vol.1, pp.893-898, 1987. ,
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain, Nature, vol.421, pp.744-752, 2003. ,
A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage, Nat Med, vol.13, pp.139-184, 2007. ,
T(H)17 cytokines in autoimmune neuro-inflammation, Curr Opin Immunol, vol.23, pp.707-719, 2011. ,
Les lymphocytes TH17 : différen-ciation, phénotype, fonctions, et implications en pathologie et thérapeutique humaine, Rev Med Interne, vol.32, pp.292-301, 2011. ,
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation, J Exp Med, vol.201, pp.233-273, 2005. ,
Th17 cell, the new player of neuroinflammatory process in multiple sclerosis, Scand J Immunol, vol.74, pp.1-13, 2011. ,
Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis, Mult Scler, vol.5, pp.101-105, 1999. ,
Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis, Am J Pathol, vol.172, pp.146-55, 2008. ,
Multiple sclerosis immunology: the healthy immune system vs the MS immune system, Neurology, vol.74, pp.2-8, 2010. ,
Multiple sclerosis: a complicated picture of autoimmunity, Nat Immunol, vol.8, pp.913-922, 2007. ,
Cutting edge: Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis, J Immunol, vol.181, pp.3750-3754, 2008. ,
IL-23 modulated myelin-specific T cells induce EAE via an IFN? driven IL-17 independent pathway, Brain Behav Immun, vol.25, pp.932-939, 2011. ,
Pathogenic CD8(+) T cells in multiple sclerosis, Ann Neurol, vol.66, pp.132-173, 2009. ,
Oligoclonal expansion of memory CD8+ T cells in cerebrospinal fluid from multiple sclerosis patients, Brain, vol.125, pp.538-50, 2002. ,
CSF enrichment of highly differentiated CD8+ T cells in early multiple sclerosis, Clin Immunol, vol.123, pp.105-118, 2007. ,
Role of CD8 T cell subsets in the pathogenesis of multiple sclerosis, FEBS Letters, vol.585, pp.3758-63, 2011. ,
Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes, Am J Pathol, vol.159, pp.809-824, 2001. ,
Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases, Trends Neurosci, vol.25, pp.313-322, 2002. ,
CD161(high)CD8+ T cells bear pathogenetic potential in multiple sclerosis, Brain, vol.134, issue.2, pp.542-54, 2011. ,
C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE, Nat Immunol, vol.10, pp.514-537, 2009. ,
Antimicrobial activity of mucosal-associated invariant T cells, Nat Immunol, vol.11, pp.701-709, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00550333
Bar-Or A, Zamvil SS. B cells in multiple sclerosis: connecting the dots, Curr Opin Immunol, vol.23, pp.713-733, 2011. ,
The evidence for a role of B cells in multiple sclerosis, Neurology, vol.78, pp.823-855, 2012. ,
Translational mini-review series on B cell subsets in disease. B cells in multiple sclerosis: drivers of disease pathogenesis and Trojan horse for Epstein-Barr virus entry to the central nervous system?, Clin Exp Immunol, vol.167, pp.1-6, 2012. ,
Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology, Brain, vol.130, pp.1089-104, 2007. ,
Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis, Brain, vol.134, issue.2, pp.534-575, 2011. ,
Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain, J Exp Med, vol.204, pp.2899-912, 2007. ,
Association of innate immune activation with latent Epstein-Barr virus in active MS lesions, Neurology, vol.78, pp.15-23, 2012. ,
B-cell depletion with rituximab in relapsing-remitting multiple sclerosis, N Engl J Med, vol.358, pp.676-88, 2008. ,
Identification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosis, Proc Natl Acad Sci, vol.103, pp.19057-62, 2006. ,
Cells from a subset of treatment-naïve relapsing-remitting multiple sclerosis patients elicit CD4(+) T-cell proliferation and IFN-? production in response to myelin basic protein and myelin oligodendrocyte glycoprotein, Eur J Immunol, vol.40, pp.2942-56, 2010. ,
Bar-Or A. Distinct profiles of human B cell effector cytokines: a role in immune regulation?, J Immunol, vol.172, pp.3422-3429, 2004. ,
IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+ CD4+ regulatory T cells, Int Immunol, vol.16, pp.249-56, 2004. ,
Regulatory B. cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis, J Immunol, vol.185, pp.2240-52, 2010. ,
Disturbed regulatory T cell homeostasis in multiple sclerosis, Trends Mol Med, vol.16, pp.58-68, 2010. ,
Regulatory T cells in the central nervous system, Immunol Rev, vol.248, pp.156-69, 2012. ,
Loss of functional suppression by CD4+ CD25+ regulatory T cells in patients with multiple sclerosis, J Exp Med, vol.199, pp.971-980, 2004. ,
Patients with relapsing-remitting multiple sclerosis have normal Treg function when cells expressing IL-7 receptor alpha-chain are excluded from the analysis, J Clin Invest, vol.118, pp.3411-3420, 2008. ,
Intracerebral human regulatory T cells: analysis of CD4+ CD25+ FOXP3+ T cells in brain lesions and cerebrospinal fluid of multiple sclerosis patients, PLoS One, vol.6, p.17988, 2011. ,
Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice, J Exp Med, vol.184, pp.2271-2279, 1996. ,
Lymphocytes in humans: a potential role in autoimmunity, Arthritis Rheum, vol.58, pp.1900-1906, 2008. ,
Immune regulatory function of B cells, Annu Rev Immunol, vol.30, pp.221-262, 2012. ,
B cells regulate autoimmunity by provision of IL-10, Nat Immunol, vol.3, pp.944-50, 2002. ,
B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer, Ann NY Acad Sci, vol.1183, pp.38-57, 2010. ,
Distinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosis, J Immunol, vol.178, pp.6092-6101, 2007. ,
Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells, Blood, vol.117, pp.530-571, 2011. ,
Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naïve/memory Breg ratio during a relapse but not in remission, J Neuroimmunol, vol.239, pp.80-86, 2011. ,
Potassium channel KIR4.1 as an immune target in multiple sclerosis, N Engl J Med, vol.367, pp.115-138, 2012. ,
Why must T cells be cross-reactive?, Nat Rev Immunol, vol.12, pp.669-77, 2012. ,
Epstein-Barr virus and multiple sclerosis, J Neurol Neurosurg Psychiatr, vol.82, pp.1142-1150, 2011. ,
Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs, Nat Immunol, vol.11, pp.628-662, 2010. ,
Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation, Nat Med, vol.13, pp.1173-1178, 2007. ,
Epstein-Barr virus infection of human brain microvessel endothelial cells: a novel role in multiple sclerosis, J Neuroimmunol, vol.230, pp.173-180, 2011. ,
CD8+ T-cell deficiency, epstein-barr virus infection, vitamin d deficiency, and steps to autoimmunity: a unifying hypothesis, Autoimmune Dis, p.189096, 2012. ,
Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion, Ann Neurol, vol.55, pp.458-68, 2004. ,