O. P. Rekvig and J. C. Nossent, Anti-double-stranded DNA antibodies, nucleosomes, and systemic lupus erythematosus: a time for new paradigms?, Arthritis Rheum, vol.48, pp.300-312, 2003.

E. E. Brown, J. C. Edberg, and R. P. Kimberly, Fc receptor genes and the systemic lupus erythematosus diathesis, Autoimmunity, vol.40, pp.567-81, 2007.

J. H. Anolik, B cell biology and dysfunction in SLE, Bull NYU Hosp Jt Dis, vol.65, pp.182-188, 2007.

P. Cohen, T-and B-cell abnormalities in systemic lupus, J Invest Dermatol, vol.100, pp.69-72, 1993.

I. Sanz and F. Lee, B cells as therapeutic targets in SLE, Nat Rev Rheumatol, vol.6, pp.326-363, 2010.

, Immunology, vol.140, pp.123-132

L. Ronnblom and K. B. Elkon, Cytokines as therapeutic targets in SLE, Nat Rev Rheumatol, vol.6, pp.339-386, 2010.

J. C. Crispin, V. C. Kyttaris, C. Terhorst, and G. C. Tsokos, T cells as therapeutic targets in SLE, Nat Rev Rheumatol, vol.6, pp.317-342, 2010.

C. G. Katsiari, S. Liossis, and P. P. Sfikakis, The pathophysiologic role of monocytes and macrophages in systemic lupus erythematosus: a reappraisal, Semin Arthritis Rheum, vol.39, pp.491-503, 2010.

U. S. Gaipl, L. E. Munoz, and G. Grossmayer, Clearance deficiency and systemic lupus erythematosus (SLE), J Autoimmun, vol.28, pp.114-135, 2007.

L. E. Muñoz, C. Janko, and G. E. Grossmayer, Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus, Arthritis Rheum, vol.60, pp.1733-1775, 2009.

K. E. Sullivan, A. Suriano, K. Dietzmann, J. Lin, D. Goldman et al., The TNFa locus is altered in monocytes from patients with systemic lupus erythematosus, Clin Immunol, vol.123, pp.74-81, 2007.

N. Figueroa-vega, G. Galindo-rodr-iguez, S. Bajaña, D. Portales-p-erez, C. Abud-mendoza et al., Phenotypic analysis of IL-10-treated, monocytederived dendritic cells in patients with systemic lupus erythematosus, Scand J Immunol, vol.64, pp.668-76, 2006.

S. Kikuchi, M. Santiago-raber, H. Amano, E. Amano, L. Fossati-jimack et al., Contribution of NZB autoimmunity 2 to Y-linked autoimmune acceleration-induced monocytosis in association with murine systemic lupus, J Immunol, vol.176, pp.3240-3247, 2006.

M. M?-uller and M. Emmend?-orffer-a,-lohmann-matthes, Expansion and high proliferate potential of the macrophage system throughout life time of lupus-prone NZB/W and MRL lpr/lpr mice. Lack of down-regulation of extramedullar macrophage proliferation in the postnatal period, Eur J Immunol, vol.21, pp.2211-2218, 1991.

M. Santiago-raber, H. Amano, and E. Amano, Fcc receptor-dependent expansion of a hyperactive monocyte subset in lupus-prone mice, Arthritis Rheum, vol.60, pp.2408-2425, 2009.

T. Kuroiwa and E. G. Lee, Cellular interactions in the pathogenesis of lupus nephritis: the role of T cells and macrophages in the amplification of the inflammatory process in the kidney, Lupus, vol.7, pp.597-603, 1998.

M. Frosch, T. Vogl, R. Waldherr, C. Sorg, C. Sunderk?-otter et al., Expression of MRP8 and MRP14 by macrophages is a marker for severe forms of glomerulonephritis, J Leukoc Biol, vol.75, pp.198-206, 2004.

F. A. Houssiau and E. M. Ginzler, Current treatment of lupus nephritis, Lupus, vol.17, pp.426-456, 2008.

N. G. Abraham and A. Kappas, Pharmacological and clinical aspects of hemeoxygenase, Pharmacol Rev, vol.60, pp.79-127, 2008.

S. R-emy, P. Blancou, and L. Tesson, Carbon monoxide inhibits TLR-induced dendritic cell immunogenicity, J Immunol, vol.182, pp.1877-84, 2009.

T. Simon, S. Pogu, and V. Tardif, Carbon monoxide-treated dendritic cells decrease b1-integrin induction on CD8

, + T cells and protect from type 1 diabetes, Eur J Immunol, vol.43, pp.209-227, 2013.

J. Listopad, K. Asadullah, C. Sievers, T. Ritter, C. Meisel et al., Heme oxygenase-1 inhibits T cell-dependent skin inflammation and differentiation and function of antigen-presenting cells, Exp Dermatol, vol.16, pp.661-70, 2007.

F. P. Choraâa and A. Cunha, Hemeoxygenase-1 and carbon monoxide suppress autoimmune neuroinflammation, J Clinl Invest, vol.117, pp.438-485, 2007.

A. Moreau, M. Hill, and . Th, Tolerogenic dendritic cells actively inhibit T cells through heme oxygenase-1 in rodents and in nonhuman primates, FASEB J, vol.23, pp.3070-3077, 2009.

Y. Takeda, M. Takeno, and M. Iwasaki, Chemical induction of HO-1 suppresses lupus nephritis by reducing local iNOS expression and synthesis of anti-dsDNA antibody, Clin Exp Immunol, vol.138, pp.237-281, 2004.

P. Blancou, V. Tardif, T. Simon, S. Carreño, L. Kalergis et al., Suppression and Regulation of Immune Responses SE -18, pp.677-247, 2011.

M. H. Kapturczak, C. Wasserfall, T. Brusko, M. Campbell-thompson, T. M. Ellis et al., Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse, Am J Pathol, vol.165, pp.1045-53, 2004.

A. A. Herrada, C. Llanos, and J. P. Mackern-oberti, Haemoxygenase 1 expression is altered in monocytes from patients with systemic lupus erythematosus, Immunology, vol.136, pp.414-438, 2012.

T. Takai, M. Ono, M. Hikida, H. Ohmori, and J. V. Ravetch, Augmented humoral and anaphylactic responses in FccRII-deficient mice, Nature, vol.379, pp.346-355, 1996.

A. M. Kalergis and J. V. Ravetch, Inducing tumor immunity through the selective engagement of activating Fcc receptors on dendritic cells, J Exp Med, vol.195, pp.1653-1662, 2002.

M. Li, D. H. Kim, and P. L. Tsenovoy, Treatment of obese diabetic mice with a hemeoxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance, Diabetes, vol.57, pp.1526-1561, 2008.

Y. Cai, G. Cho, and C. Ju, Activated microglia are less vulnerable to hemin toxicity due to nitric oxide-dependent inhibition of JNK and p38 MAPK activation, J Immunol, vol.187, pp.1314-1335, 2011.

S. A. Riquelme, S. M. Bueno, and A. M. Kalergis, IgG keeps virulent Salmonella from evading dendritic cell uptake, Immunology, vol.136, pp.291-305, 2012.

B. Zhang, X. Zhang, F. Tang, L. Zhu, and Y. Liu, Reduction of forkhead box P3 levels in CD4 + CD25 high T cells in patients with new-onset systemic lupus erythematosus, Clin Exp Immunol, vol.153, pp.182-189, 2008.

M. Miyara, Z. Amoura, and C. Parizot, Global natural regulatory T cell depletion in active systemic lupus erythematosus, J Immunol, vol.175, pp.8392-400, 2005.

R. Gerli, G. Nocentini, A. Alunno, E. B. Bocci, R. Bianchini et al., Identification of regulatory T cells in systemic lupus erythematosus, Autoimmun Rev, vol.8, pp.426-456, 2009.

S. Muller, J. Dieker, A. Tincani, and P. L. Meroni, Pathogenic anti-nucleosome antibodies, Lupus, vol.17, pp.431-437, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00311833

A. Yachie, T. Toma, K. Mizuno, H. Okamoto, S. Shimura et al., Heme oxygenase-1 production by peripheral blood monocytes during acute inflammatory illnesses of children, Exp Biol Med, vol.228, pp.550-556, 2003.

B. Liu, W. Tan, and A. Barsoum, IL-17 is a potent synergistic factor with GM-CSF in mice in stimulating myelopoiesis, dendritic cell expansion, proliferation, and functional enhancement, Exp Hematol, vol.38, pp.877-84, 2010.

K. Yoshimoto, M. Tanaka, and M. Kojima, Regulatory mechanisms for the production of BAFF and IL-6 are impaired in monocytes of patients of primary Sj? ogren's syndrome, Arthritis Res Ther, vol.13, p.170, 2011.

K. Hora, J. A. Satriano, A. Santiago, T. Mori, E. R. Stanley et al., Receptors for IgG complexes activate synthesis of monocyte chemoattractant peptide 1 and colony-stimulating factor 1, Proc Natl Acad Sci U S A, vol.89, pp.1745-1754, 1992.

S. W. Ryter, J. Alam, and A. Choi, Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications, Physiol Rev, vol.86, pp.583-650, 2006.

D. M. Mosser and J. P. Edwards, Exploring the full spectrum of macrophage activation, Nat Rev Immunol, vol.8, pp.958-69, 2008.

E. Ribechini, V. Greifenberg, S. Sandwick, and M. Lutz, Subsets, expansion and activation of myeloid-derived suppressor cells, Med Microbiol Immunol, vol.199, pp.273-81, 2010.

C. Pasare and R. Medzhitov, Toll pathway-dependent blockade of CD4 + CD25

, + T cell-mediated suppression by dendritic cells, Science, vol.299, pp.1033-1039, 2003.

M. Fujimoto, M. Nakano, and F. Terabe, The influence of excessive IL-6 production in vivo on the development and function of Foxp3 + regulatory T cells, J Immunol, 2011.

C. Chauveau, S. Royer, and P. J. , Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression, Blood, vol.106, pp.1694-702, 2005.

R. A. Galbraith and A. Kappas, Regulation of food intake and body weight in rats by the synthetic heme analogue cobalt protoporphyrin, Am J Physiol, vol.261, pp.1388-94, 1991.

D. W. Rosenberg, G. S. Drummond, and T. J. Smith, Depletion of cytochrome P-450 by thyroid hormone and cobalt-protoporphyrin IX in rat liver: evidence that susceptibility varies among forms of the hemeprotein, Pharmacology, vol.51, pp.254-62, 1995.

C. M. Reilly, L. W. Farrelly, and D. Viti, Modulation of renal disease in MRL/lpr mice by pharmacologic inhibition of inducible nitric oxide synthase, Kidney Int, vol.61, pp.839-885, 2002.

M. Fujii, T. Inoguchi, S. Sasaki, Y. Maeda, J. Zheng et al., Bilirubin and biliverdin protect rodents against diabetic nephropathy by downregulating NAD(P) H oxidase, Kidney Int, vol.78, pp.905-924, 2010.