F. Costa, J. E. Hagan, J. Calcagno, M. Kane, P. Torgerson et al., Global Morbidity and Mortality of Leptospirosis: A Systematic Review, PLoS Negl Trop Dis, vol.9, issue.9, p.26379143, 2015.

A. I. Ko, C. Goarant, and M. Picardeau, Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen, Nat Rev Microbiol, vol.7, issue.10, pp.736-783, 2009.
URL : https://hal.archives-ouvertes.fr/pasteur-00450871

F. Vernel-pauillac and C. Werts, Recent findings related to immune responses against leptospirosis and novel strategies to prevent infection, Microbes Infect, vol.20, issue.9, p.29452258, 2018.

G. Ratet, F. J. Veyrier, M. Fanton-d'andon, X. Kammerscheit, M. A. Nicola et al., Live imaging of bioluminescent Leptospira interrogans in mice reveals renal colonization as a stealth escape from the blood defenses and antibiotics, PLoS Negl Trop Dis, vol.8, issue.12, p.25474719, 2014.
URL : https://hal.archives-ouvertes.fr/pasteur-01415707

M. Gomes-solecki, I. Santecchia, and C. Werts, Animal Models of Leptospirosis: Of Mice and Hamsters, Front Immunol, vol.8, p.28270811, 2017.

S. Akira, S. Uematsu, and O. Takeuchi, Pathogen recognition and innate immunity, Cell, vol.124, issue.4, p.16497588, 2006.

T. H. Mogensen, Pathogen recognition and inflammatory signaling in innate immune defenses, Table of Contents, vol.22, pp.240-73, 2009.

S. W. Brubaker, K. S. Bonham, I. Zanoni, and J. C. Kagan, Innate immune pattern recognition: a cell biological perspective, Annu Rev Immunol, vol.33, pp.257-90, 2015.

M. A. Nahori, E. Fournie-amazouz, N. S. Que-gewirth, V. Balloy, M. Chignard et al., Differential TLR recognition of leptospiral lipid A and lipopolysaccharide in murine and human cells, J Immunol, vol.175, issue.9, p.16237097, 2005.

C. Chassin, M. Picardeau, J. M. Goujon, P. Bourhy, N. Quellard et al., TLR4-and TLR2-mediated B cell responses control the clearance of the bacterial pathogen, Leptospira interrogans, J Immunol, vol.183, issue.4, pp.2669-77, 2009.

L. Richer, H. H. Potula, R. Melo, A. Vieira, and M. Gomes-solecki, Mouse model for sublethal Leptospira interrogans infection, Infect Immun, vol.83, issue.12, pp.4693-700, 2015.

G. Ratet, I. Santecchia, M. Fanton-d'andon, F. Vernel-pauillac, R. Wheeler et al., LipL21 lipoprotein binding to peptidoglycan enables Leptospira interrogans to escape NOD1 and NOD2 recognition, PLoS Pathog, vol.13, issue.12, p.29211798, 2017.

L. L. Bourhis and C. Werts, Role of Nods in bacterial infection, Microbes Infect, vol.9, issue.5, p.17379560, 2007.

C. Werts, Interaction of Leptospira with the Innate Immune System, Curr Top Microbiol Immunol, vol.415, pp.163-87, 2018.

S. Li, D. M. Ojcius, S. Liao, L. Li, F. Xue et al., Replication or death: distinct fates of pathogenic Leptospira strain Lai within macrophages of human or mouse origin, Innate Immun, vol.16, issue.2, pp.80-92, 2010.

C. Toma, G. L. Murray, T. Nohara, M. Mizuyama, N. Koizumi et al., Leptospiral outer membrane protein LMB216 is involved in enhancement of phagocytic uptake by macrophages, Cell Microbiol, vol.16, issue.9, p.24655538, 2014.

C. Toma, N. Okura, C. Takayama, and T. Suzuki, Characteristic features of intracellular pathogenic Leptospira in infected murine macrophages, Cell Microbiol, vol.13, issue.11, p.21819516, 2011.

G. Pretre, N. Olivera, M. Cedola, S. Haase, L. Alberdi et al., Role of inducible nitric oxide synthase in the pathogenesis of experimental leptospirosis, Microb Pathog, vol.51, issue.3, p.21497651, 2011.

M. Fanton-d'andon, N. Quellard, B. Fernandez, G. Ratet, S. Lacroix-lamande et al., Leptospira Interrogans induces fibrosis in the mouse kidney through Inos-dependent, TLR-and NLR-independent signaling pathways, PLoS Negl Trop Dis, vol.8, issue.1, p.24498450, 2014.

H. H. Potula, L. Richer, C. Werts, and M. Gomes-solecki, Pre-treatment with Lactobacillus plantarum prevents severe pathogenesis in mice infected with Leptospira interrogans and may be associated with recruitment of myeloid cells, PLoS Negl Trop Dis, vol.11, issue.8, p.28841659, 2017.
URL : https://hal.archives-ouvertes.fr/pasteur-01658330

M. G. Netea, L. A. Joosten, E. Latz, K. H. Mills, G. Natoli et al., Trained immunity: A program of innate immune memory in health and disease, Science, vol.352, issue.6284, p.27102489, 2016.

D. C. Ifrim, J. Quintin, L. A. Joosten, C. Jacobs, T. Jansen et al., Trained immunity or tolerance: opposing functional programs induced in human monocytes after engagement of various pattern recognition receptors, Clin Vaccine Immunol, vol.21, issue.4, p.24521784, 2014.

D. Boraschi and P. Italiani, Innate Immune Memory: Time for Adopting a Correct Terminology, Front Immunol, vol.9, p.29725331, 2018.

E. Topfer, D. Boraschi, and P. Italiani, Innate Immune Memory: The Latest Frontier of Adjuvanticity, J Immunol Res, p.478408, 2015.

O. Levy and M. G. Netea, Innate immune memory: implications for development of pediatric immunomodulatory agents and adjuvanted vaccines, Pediatr Res, vol.75, issue.1-2, p.24352476, 2014.

M. G. Netea, J. Quintin, and J. W. Van-der-meer, Trained immunity: a memory for innate host defense, Cell Host Microbe, vol.9, issue.5, p.21575907, 2011.

J. Kleinnijenhuis, J. Quintin, F. Preijers, C. S. Benn, L. A. Joosten et al., Long-lasting effects of BCG vaccination on both heterologous Th1/Th17 responses and innate trained immunity, J Innate Immun, vol.6, issue.2, pp.152-160, 2014.

J. Kleinnijenhuis, J. Quintin, F. Preijers, L. A. Joosten, C. Jacobs et al., BCG-induced trained immunity in NK cells: Role for non-specific protection to infection, Clin Immunol, vol.155, issue.2, p.25451159, 2014.

V. H. Matsubara, K. H. Ishikawa, E. S. Ando-suguimoto, B. Bueno-silva, A. Nakamae et al., Probiotic Bacteria Alter Pattern-Recognition Receptor Expression and Cytokine Profile in a Human Macrophage Model Challenged with Candida albicans and Lipopolysaccharide, Front Microbiol, vol.8, p.29238325, 2017.

R. J. Arts, L. A. Joosten, and M. G. Netea, Immunometabolic circuits in trained immunity, Semin Immunol, vol.28, issue.5, p.27686054, 2016.

R. Arts, A. Carvalho, L. Rocca, C. Palma, C. Rodrigues et al., Immunometabolic Pathways in BCG-Induced Trained Immunity, Cell Rep, vol.17, issue.10, p.27926861, 2016.

C. Van-der-heijden, M. P. Noz, L. Joosten, M. G. Netea, N. P. Riksen et al., Epigenetics and Trained Immunity, Antioxid Redox Signal, vol.29, issue.11, p.28978221, 2018.

J. M. Wells, Immunomodulatory mechanisms of Lactobacilli, Microb Cell Fact, vol.10, p.21995674, 2011.

C. M. Percopo, K. D. Dyer, K. E. Garcia-crespo, S. J. Gabryszewski, A. L. Shaffer et al., B cells are not essential for Lactobacillus-mediated protection against lethal pneumovirus infection, J Immunol, vol.192, issue.11, p.24748495, 2014.

T. A. Rice, T. A. Brenner, C. M. Percopo, M. Ma, J. D. Keicher et al., Signaling via pattern recognition receptors NOD2 and TLR2 contributes to immunomodulatory control of lethal pneumovirus infection, Antiviral Res, vol.132, p.27312104, 2016.

V. Pavot, N. Rochereau, J. Resseguier, A. Gutjahr, C. Genin et al., Cutting edge: New chimeric NOD2/TLR2 adjuvant drastically increases vaccine immunogenicity, J Immunol, vol.193, issue.12, p.25392526, 2014.
DOI : 10.4049/jimmunol.1402184

URL : http://www.jimmunol.org/content/193/12/5781.full.pdf

M. F. Lacroix-lamande-s,-d'andon, M. E. Ratet, G. Philpott, D. J. Girardin, and S. E. , Downregulation of the Na/K-ATPase pump by leptospiral glycolipoprotein activates the NLRP3 inflammasome, J Immunol, vol.188, issue.6, p.22323544, 2012.

J. Kleinnijenhuis, J. Quintin, F. Preijers, L. A. Joosten, D. C. Ifrim et al., Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes, Proc Natl Acad Sci U S A, vol.109, issue.43, p.22988082, 2012.

E. Isogai, H. Kitagawa, H. Isogai, Y. Kurebayashi, and N. Ito, Phagocytosis as a defense mechanism against infection with leptospiras, Zentralbl Bakteriol Mikrobiol Hyg A, vol.261, issue.1, p.3010604, 1986.

M. F. Ferrer, E. Scharrig, C. N. Ripodas, A. L. Drut, R. et al., Macrophages and Galectin 3 Control Bacterial Burden in Acute and Subacute Murine Leptospirosis That Determines Chronic Kidney Fibrosis, Front Cell Infect Microbiol, vol.8, p.30425972, 2018.

J. M. Davis, D. A. Haake, and L. Ramakrishnan, Leptospira interrogans stably infects zebrafish embryos, altering phagocyte behavior and homing to specific tissues, PLoS Negl Trop Dis, vol.3, issue.6, p.463, 2009.

E. Kaufmann, J. Sanz, J. L. Dunn, N. Khan, L. E. Mendonca et al., BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis, Cell, vol.172, issue.1-2, p.29328912, 2018.

I. Mitroulis, K. Ruppova, B. Wang, L. S. Chen, M. Grzybek et al., Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity, Cell, vol.172, issue.1-2, p.29328910, 2018.

B. Machiels, M. Dourcy, X. Xiao, J. Javaux, C. Mesnil et al., A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes, Nat Immunol, vol.18, issue.12, p.29035391, 2017.

A. A. Devlin, P. J. Halvorsen, J. C. Miller, and S. M. Laster, Il-10 deficient mice express IFN-gamma mRNA and clear Leptospira interrogans from their kidneys more rapidly than normal C57BL/6 mice. Immunobiology, vol.222, p.28237664, 2017.

R. L. Zuerner, D. P. Alt, M. V. Palmer, T. C. Thacker, and S. C. Olsen, A Leptospira borgpetersenii serovar Hardjo vaccine induces a Th1 response, activates NK cells, and reduces renal colonization, Clin Vaccine Immunol, vol.18, issue.4, p.21288995, 2011.

K. Buffen, M. Oosting, J. Quintin, A. Ng, J. Kleinnijenhuis et al., Autophagy controls BCG-induced trained immunity and the response to intravesical BCG therapy for bladder cancer, PLoS Pathog, vol.10, issue.10, p.25356988, 2014.

J. G. Magalhaes, J. H. Fritz, L. Bourhis, L. Sellge, G. Travassos et al., Nod2-dependent Th2 polarization of antigen-specific immunity, J Immunol, vol.181, issue.11, pp.7925-7960, 2008.

F. K. Seixas, E. F. Da-silva, D. D. Hartwig, G. M. Cerqueira, M. Amaral et al., Recombinant Mycobacterium bovis BCG expressing the LipL32 antigen of Leptospira interrogans protects hamsters from challenge, Vaccine, vol.26, issue.1, p.18063449, 2007.

J. P. Sullivan, N. Nair, H. H. Potula, and M. Gomes-solecki, Eyedrop Inoculation Causes Sublethal Leptospirosis in Mice, Infect Immun, vol.85, issue.4, p.28115508, 2017.