V. M. Bedell, Y. Wang, J. M. Campbell, T. L. Poshusta, C. G. Starker et al., In vivo genome editing using a highefficiency TALEN system, Nature, vol.491, issue.7422, pp.114-118, 2012.

P. R. Blackburn, J. M. Campbell, K. J. Clark, and S. C. Ekker, The CRISPR system-keeping zebrafish gene targeting fresh, Zebrafish, vol.10, issue.1, pp.116-118, 2013.

A. J. Brown, D. A. Fisher, E. Kouranova, A. Mccoy, K. Forbes et al., Whole-rat conditional gene knockout via genome editing, Nat Methods, vol.10, pp.638-640, 2013.

L. Cade, D. Reyon, W. Y. Hwang, S. Q. Tsai, S. Patel et al., Highly efficient generation of heritable zebrafish gene mutations using homo-and heterodimeric TALENs, Nucleic Acids Res, vol.40, issue.16, pp.8001-8010, 2012.

D. F. Carlson, W. Tan, S. G. Lillico, D. Stverakova, C. Proudfoot et al., Fahrenkrug SC (2012) Efficient TALEN-mediated gene knockout in livestock, Proc Natl Acad Sci, vol.109, issue.43, pp.17382-17387

E. Charpentier and J. Doudna, Biotechnology: rewriting a genome, Nature, vol.495, issue.7439, pp.50-51, 2013.

K. Chylinski, L. Rhun, A. Charpentier, and E. , The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems, RNA Biol, vol.10, issue.5, pp.726-737, 2013.

J. Clark and B. Whitelaw, A future for transgenic livestock, Nat Rev Genet, vol.4, issue.10, pp.825-833, 2003.

K. J. Clark, D. F. Voytas, and S. C. Ekker, A TALE of two nucleases: gene targeting for the masses, Zebrafish, vol.8, issue.3, pp.147-149, 2011.

X. Cui, J. D. Fisher, D. A. Wu, Y. Briner, D. M. Weinstein et al., Targeted integration in rat and mouse embryos with zincfinger nucleases, Nat Biotechnol, vol.29, pp.64-67, 2011.

E. Deltcheva, K. Chylinski, C. M. Sharma, K. Gonzales, Y. Chao et al., CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III, Nature, vol.471, issue.7340, pp.602-607, 2011.

S. C. Fahrenkrug, A. Blake, D. F. Carlson, T. Doran, A. Van-eenennaam et al., Precision genetics for complex objectives in animal agriculture, J Animal Sci, vol.88, issue.7, pp.2530-2539, 2010.

A. M. Geurts, G. J. Cost, Y. Freyvert, B. Zeitler, J. C. Miller et al., Knockout rats via embryo microinjection of zinc-finger nucleases, Science, vol.325, p.433, 2009.

W. Y. Hwang, Y. Fu, D. Reyon, M. L. Maeder, S. Q. Tsai et al., Efficient genome editing in zebrafish using a CRISPR-Cas system, Nat Biotechnol, vol.31, issue.3, pp.227-229, 2013.

M. Jinek, K. Chylinski, I. Fonfara, M. Hauer, and J. A. Doudna, Charpentier E (2012) A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity, Science, vol.337, issue.6096, pp.816-821

L. Provost, F. Lillico, S. Passet, B. Young, R. Whitelaw et al., Zinc finger nuclease technology heralds a new era in mammalian transgenesis, Trends Biotechnol, vol.28, issue.3, pp.134-141, 2010.
URL : https://hal.archives-ouvertes.fr/hal-01193371

P. Li, C. Tong, R. Mehrian-shai, L. Jia, N. Wu et al., Germline competent embryonic stem cells derived from rat blastocysts, Cell, vol.135, pp.1299-1310, 2008.

R. Loew, N. Heinz, M. Hampf, H. Bujard, and M. Gossen, Improved Tet-responsive promoters with minimized background expression, BMC Biotechnol, vol.10, p.81, 2010.

S. Menoret, A. L. Iscache, L. Tesson, R. S. Usal, C. Osborn et al., Characterization of immunoglobulin heavy chain knockout rats, Eur J Immunol, vol.40, pp.2932-2941, 2010.

S. Ménoret, S. Fontanière, D. Jantz, L. Tesson, R. Thinard et al., Generation of Rag1-knockout immunodeficient rats and mice using engineered meganucleases, FASEB J, vol.27, pp.703-711, 2012.

M. J. Osborn, B. Ma, A. S. Binnie, A. Dilley, J. Yang et al., Highaffinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igkappa/Iglambda loci bearing the rat CH region, J Immunol, vol.190, pp.1481-1490, 2013.

K. Schönig, H. Bujard, and M. Gossen, The power of reversibility: regulating gene activities via tetracycline-controlled transcription, Methods Enzymol, vol.477, pp.429-453, 2010.

K. Schönig, S. Freundlieb, and M. Gossen, Tet-Transgenic Rodents: a comprehensive, up-to date database, Transgenic Res, vol.22, issue.2, pp.251-254, 2013.

J. Suk, A. Bruce, R. Gertz, C. Warkup, C. B. Whitelaw et al., Dolly Transgenic Res, vol.22, p.1071, 2007.

, Assessing commercial and regulatory trends in cloned livestock, Nat Biotechnol, vol.25, issue.1, pp.47-53

L. Tesson, J. Cozzi, S. Menoret, R. S. Usal, C. Fraichard et al., Transgenic modifications of the rat genome, Transgenic Res, vol.14, pp.531-546, 2005.

L. Tesson, C. Usal, S. Menoret, E. Leung, B. J. Niles et al., Anegon I, Cost GJ (2011) Knockout rats generated by embryo microinjection of TALENs, Nat Biotechnol, vol.29, pp.695-696

B. Wefers, M. Meyer, O. Ortiz, H. De-angelis, M. Hansen et al., Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides, Proc Natl Acad Sci, vol.110, issue.10, pp.3782-3787, 2013.

I. Weidenfeld, M. Gossen, R. Löw, D. Kentner, S. Berger et al., Inducible expression of coding and inhibitory RNAs from retargetable genomic loci, Nucleic Acids Res, vol.37, issue.7, p.50, 2009.

Y. Zu, X. Tong, Z. Wang, D. Liu, R. Pan et al., TALEN-mediated precise genome modification by homologous recombination in zebrafish, Nat Methods, vol.10, issue.4, pp.329-331, 2013.