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Emerging role of IL-17 and Th17 cells in systemic lupus erythematosus

Abstract : Despite the success of targeted therapies in managing immune-mediated inflamma-tory diseases (IMIDs) such as RA, IBDs, MS and psoriasis, unmet needs for such approach in SLE are widely recognized. In the past 2 years, exciting insights supporting previous lines of evidence on the role of the IL-23/IL-17 axis in SLE have emerged. This is of particular importance as IL-17 blockers have now moved successfully into the clinical space, as illustrated in psoriasis and ankylosing spondylitis. However, recent fundamental studies also highlighted unexpected aspects of IL-17/Th17 biology whose comprehension may prevent disappointing results of IL-17 targeting such as those obtained in Crohn's disease. Therefore, establishing a current picture of the IL-17 pre-clinical situation in SLE is timely in order to plan future proof-of-concept studies in human.
Keywords : IL-17 Th17 SLE
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Jérôme C. Martin, Dominique L. Baeten, Régis Josien. Emerging role of IL-17 and Th17 cells in systemic lupus erythematosus. Clinical Immunology, Elsevier, 2014, 154 (1), pp.1-12. ⟨10.1016/j.clim.2014.05.004⟩. ⟨inserm-02164493⟩



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