Tolerogenic dendritic cells, Annu. Rev. Immunol, vol.21, pp.685-711, 2003. ,
Regulatory dendritic cell therapy: from rodents to clinical application, Immunol. Lett, vol.161, pp.216-221, 2014. ,
Human peripheral blood monocyte-derived interleukin-10-induced semi-mature dendritic cells induce anergic CD4(+) and CD8(+) T cells via presentation of the internalized soluble antigen and cross-presentation of the phagocytosed necrotic cellular fragments, Cell. Immunol, vol.215, pp.186-194, 2002. ,
Modified dendritic cells coexpressing self and allogeneic major histocompatability complex molecules: an efficient way to induce indirect pathway regulation, J. Am. Soc. Nephrol, vol.15, pp.987-997, 2004. ,
Rapamycin-treated, alloantigen-pulsed host dendritic cells induce Ag-specific T cell regulation and prolong graft survival, Am. J. Transplant, vol.5, pp.228-236, 2005. ,
Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance, J. Immunol, vol.178, pp.7018-7031, 2007. ,
Indoleamine 2,3-dioxygenase gene transfer prolongs cardiac allograft survival, Am. J. Physiol. Heart Circ. Physiol, vol.293, pp.3415-3423, 2007. ,
Genetic engineering of dendritic cells to express immunosuppressive molecules (viral IL-10, TGF-beta, and CTLA4Ig), J. Leukoc. Biol, vol.66, pp.293-296, 1999. ,
Prolongation of heart allograft survival by immature dendritic cells generated from recipient type bone marrow progenitors, Am. J. Transplant, vol.5, pp.255-267, 2005. ,
Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo, Eur. J. Immunol, vol.30, pp.1813-1822, 2000. ,
Immature rat myeloid dendritic cells generated in low-dose granulocyte macrophage-colony stimulating factor prolong donor-specific rat cardiac allograft survival, Transplantation, vol.75, pp.521-528, 2003. ,
Anti-ICAM-1 antibody and CTLA-4Ig synergistically enhance immature dendritic cells to induce donor-specific immune tolerance in vivo, Immunol. Lett, vol.90, pp.33-42, 2003. ,
Induction of transplant tolerance with immunodominant allopeptide-pulsed host lymphoid and myeloid dendritic cells, Am. J. Transplant, vol.1, pp.129-137, 2001. ,
Indirect allorecognition in acquired thymic tolerance: induction of donor-specific tolerance to rat cardiac allografts by allopeptide-pulsed host dendritic cells, Transplantation, vol.68, pp.1827-1834, 1999. ,
Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells, J. Exp. Med, vol.198, pp.235-247, 2003. ,
Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts, Nat. Immunol, vol.7, pp.652-662, 2006. ,
Induction of regulatory T cells and dominant tolerance by dendritic cells incapable of full activation, J. Immunol, vol.179, pp.967-976, 2007. ,
Regulatory dendritic cells protect against cutaneous chronic graftversus-host disease mediated through CD4+CD25+Foxp3+ regulatory T cells, Blood, vol.110, pp.3793-3803, 2007. ,
Donor-specific allograft tolerance by administration of recipient-derived immature dendritic cells and suboptimal immunosuppression, Transplantation, vol.79, pp.969-972, 2005. ,
Synergistic tolerance induced by LF15-0195 and anti-CD45RB monoclonal antibody through suppressive dendritic cells, Transplantation, vol.75, pp.1160-1165, 2003. ,
LF 15-0195, a novel immunosuppressive agent prevents rejection and induces operational tolerance in a mouse cardiac allograft model, Transplantation, vol.76, pp.644-650, 2003. ,
LF15-0195 generates tolerogenic dendritic cells by suppression of NF-kappaB signaling through inhibition of IKK activity, J. Leukoc. Biol, vol.74, pp.438-447, 2003. ,
Autologous dendritic cells prolong allograft survival through Tmem176b-dependent antigen cross-presentation, Am. J. Transplant, vol.14, pp.1021-1031, 2014. ,
Use of monoclonal antibodies to T-cell subsets for immunologic monitoring and treatment in recipients of renal allografts, N. Engl. J. Med, vol.305, pp.308-314, 1981. ,
Prophylactic use of OKT3 monoclonal antibody in cadaver kidney recipients. Utilization of OKT3 as the sole immunosuppressive agent, Transplantation, vol.41, pp.730-733, 1986. ,
CD3-specific antibodies: a portal to the treatment of autoimmunity, Nat. Rev. Immunol, vol.7, pp.622-632, 2007. ,
Induction of allograft tolerance by monoclonal CD3 antibodies: a matter of timing, Am. J. Transplant, vol.12, pp.2909-2919, 2012. ,
Delayed anti-CD3 therapy results in depletion of alloreactive T cells and the dominance of Foxp3+ CD4+ graft infiltrating cells, Am. J. Transplant, vol.13, pp.1655-1664, 2013. ,
Preparation of mouse bone marrow-derived dendritic cells with immunoregulatory properties, Methods Mol. Biol, vol.677, pp.161-168, 2011. ,
Nonmitogenic anti-CD3 monoclonal antibodies deliver a partial T cell receptor signal and induce clonal anergy, J. Exp. Med, vol.185, pp.1413-1422, 1997. ,
Identification of regulatory T cells in tolerated allografts, J. Exp. Med, vol.195, pp.1641-1646, 2002. ,
Immune privilege induced by regulatory T cells in transplantation tolerance, Immunol. Rev, vol.213, pp.239-255, 2006. ,
Intragraft mechanisms associated with the immunosuppressive versus the tolerogenic effect of CD3 antibodies in a mouse model of islet allografts, Transplant. Proc, vol.45, pp.1895-1898, 2013. ,
Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory t cells, J. Immunol, vol.187, pp.2015-2022, 2011. ,
Prolongation of cardiac allograft survival by systemic administration of immature recipient dendritic cells deficient in NF-kappaB activity, Ann. Surg, vol.241, pp.497-505, 2005. ,
Cell therapy with autologous tolerogenic dendritic cells induces allograft tolerance through interferon-gamma and epstein-barr virus-induced gene 3, Am. J. Transplant, vol.11, pp.2036-2045, 2011. ,
Cross-presentation by dendritic cells, Nat. Rev. Immunol, vol.12, pp.557-569, 2012. ,
Feedback control of regulatory T cell homeostasis by dendritic cells in vivo, J. Exp. Med, vol.206, pp.1853-1862, 2009. ,
CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4-and IL-10-dependent immunoregulation of alloresponses, J. Immunol, vol.168, pp.1080-1086, 2002. ,
Regulatory T cells in transplantation tolerance, Nat. Rev. Immunol, vol.3, pp.199-210, 2003. ,
Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance, J. Exp. Med, vol.208, pp.2043-2053, 2011. ,
Comparative study of clinical grade human tolerogenic dendritic cells, J. Transl. Med, vol.9, p.89, 2011. ,
IL-10-generated tolerogenic dendritic cells are optimal for functional regulatory T cell induction-a comparative study of human clinical-applicable DC, Clin. Immunol, vol.142, pp.332-342, 2012. ,
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus, N. Engl. J. Med, vol.346, pp.1692-1698, 2002. ,
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes, N. Engl. J. Med, vol.352, pp.2598-2608, 2005. ,
Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass, Diabetologia, vol.53, pp.614-623, 2010. ,
Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial, Protégé Trial Investigators, vol.378, pp.487-497, 2011. ,