MicroRNAs, Major Players in B Cells Homeostasis and Function

Abstract : As a main actor in humoral immunity, B cells participate in various antibody-related disorders. However, a deeper understanding of B-cell differentiation and function is needed in order to decipher their immune-modulatory roles, notably with the recent highlighting of regulatory B cells. microRNAs (miRNAs), key factors in various biological and pathological processes, have been shown to be essential for B-cell homeostasis, and therefore understanding their participation in B-cell biology could help identify biomarkers and contribute toward curing B-cell-related immune disorders. This review aims to report studies casting light on the roles played by miRNAs in B-cell lineage and function and B-cell-related immune pathologies.
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Richard Danger, Faouzi Braza, Magali Giral, Jean-Paul Soulillou, Sophie Brouard. MicroRNAs, Major Players in B Cells Homeostasis and Function. Frontiers in Immunology, Frontiers, 2014, 5, ⟨10.3389/fimmu.2014.00098⟩. ⟨inserm-02163528⟩

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