Evolving functions of endothelial cells in inflammation, Nat Rev Immunol, vol.7, pp.803-818, 2007. ,
Mechanisms of endothelial dysfunction, injury, and death, Annu Rev Pathol, vol.4, pp.71-95, 2009. ,
Metalloproteinases and their natural inhibitors in inflammation and immunity, Nat Rev Immunol, vol.13, pp.649-65, 2013. ,
The role of ADAM-mediated shedding in vascular biology, Eur J Cell Biol, vol.91, pp.472-85, 2012. ,
Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling, Mol Cell Biol, vol.29, pp.5679-95, 2009. ,
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion, Blood, vol.102, pp.1186-95, 2003. ,
ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and betacatenin nuclear signalling, EMBO J, vol.24, pp.742-52, 2005. ,
ADAM10 regulates endothelial permeability and T-cell transmigration by proteolysis of vascular endothelial cadherin, Circ Res, vol.102, pp.1192-201, 2008. ,
A disintegrin and metalloprotease 10 is a novel mediator of vascular endothelial growth factor-induced endothelial cell function in angiogenesis and is associated with atherosclerosis, Arterioscler Thromb Vasc Biol, vol.30, pp.2188-95, 2010. ,
Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) transsignaling and novel role of ADAM10 in inducible IL-6 receptor shedding, J Biol Chem, vol.286, pp.14804-14815, 2011. ,
Kuzbanian-mediated cleavage of Drosophila Notch, Genes Dev, vol.16, pp.209-230, 2002. ,
Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures, Blood, vol.118, pp.1163-74, 2011. ,
The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase ,
, Proc Natl Acad Sci, vol.100, pp.7638-7681, 2003.
Notch signaling: cell fate control and signal integration in development, Science, vol.284, pp.770-776, 1999. ,
HES and HERP families: multiple effectors of the Notch signaling pathway, J Cell Physiol, vol.194, pp.237-55, 2003. ,
Notch function in the vasculature: insights from zebrafish, mouse and man, BioEssays News Rev Mol Cell Dev Biol, vol.26, pp.225-259, 2004. ,
The Notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis, Cell, vol.137, pp.1124-1159, 2009. ,
Notch signalling in ischaemia-induced angiogenesis, Biochem Soc Trans, vol.37, pp.1221-1228, 2009. ,
Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium, Proc Natl Acad Sci, vol.98, pp.5643-5651, 2001. ,
Dll4, a novel Notch ligand expressed in arterial endothelium, Genes Dev, vol.14, pp.1313-1321, 2000. ,
Inflammation dysregulates Notch signaling in endothelial cells: implication of Notch2 and Notch4 to endothelial dysfunction, Biochem Pharmacol, vol.80, pp.2032-2073, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00637150
Impact of notch signaling on inflammatory responses in cardiovascular disorders, Int J Mol Sci, vol.14, pp.6863-88, 2013. ,
URL : https://hal.archives-ouvertes.fr/inserm-02165829
Impaired Notch4 activity elicits endothelial cell activation and apoptosis: implication for transplant arteriosclerosis, Arterioscler Thromb Vasc Biol, vol.28, pp.2258-65, 2008. ,
Notch2 signaling sensitizes endothelial cells to apoptosis by negatively regulating the key protective molecule survivin, PLoS ONE, vol.4, p.8244, 2009. ,
Analysis of relative gene expression data using realtime quantitative PCR and the 2(ÀDelta Delta C(T)) method. Methods, vol.25, pp.402-410, 2001. ,
Metalloprotease ADAM10 is required for Notch1 site 2 cleavage, J Biol Chem, vol.284, pp.31018-31045, 2009. ,
ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo, J Exp Med, vol.207, pp.623-658, 2010. ,
Noncanonical Notch signaling modulates cytokine responses of dendritic cells to inflammatory stimuli, J Immunol, vol.189, pp.1274-84, 2012. ,
Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKa/IKKb, Oncogene, vol.32, pp.4892-902, 2013. ,
TNF signaling in vascular endothelial cells, Exp Mol Pathol, vol.70, pp.317-342, 2001. ,
Human Notch-1 inhibits NF-kappa B activity in the nucleus through a direct interaction involving a novel domain, J Immunol, vol.167, pp.289-95, 1950. ,
Inhibition of endothelial cell proliferation by Notch1 signaling is mediated by repressing MAPK and PI3K/Akt pathways and requires MAML1, FASEB J Off Publ Fed Am Soc Exp Biol, vol.20, pp.1009-1020, 2006. ,
Characterization of sequential N-cadherin cleavage by ADAM10 and PS1, Neurosci Lett, vol.402, pp.278-83, 2006. ,
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts, Hum Mol Genet, vol.11, pp.2615-2639, 2002. ,
ADAM function in embryogenesis, Semin Cell Dev Biol, vol.20, pp.153-63, 2009. ,
Hypoxiamediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate, Exp Cell Res, vol.313, pp.1-9, 2007. ,
Feed-forward signaling by membrane-bound ligand receptor circuit: the case of NOTCH DELTA-like 4 ligand in endothelial cells, J Biol Chem, vol.285, pp.40681-89, 2010. ,
Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1, J Biol Chem, vol.288, pp.25477-89, 2013. ,
No evidence for a functional role of bi-directional Notch signaling during angiogenesis, PLOS ONE, vol.7, p.53074, 2012. ,
Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function, Blood, vol.107, pp.931-940, 2006. ,
The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth, Nat Rev Cancer, vol.7, pp.327-358, 2007. ,
Notch activation induces endothelial cell senescence and pro-inflammatory response: implication of Notch signaling in atherosclerosis, Atherosclerosis, vol.225, pp.296-303, 2012. ,
Stimulated shedding of vascular cell adhesion molecule 1 (VCAM-1) is mediated by tumor necrosis factor-alpha-converting enzyme (ADAM 17), J Biol Chem, vol.278, pp.37459-64, 2003. ,
Notch1 deficiency results in decreased inflammation during wound healing and regulates vascular endothelial growth factor receptor-1 and inflammatory cytokine expression in macrophages, J Immunol, vol.185, pp.4363-73, 1950. ,
TLR9 regulates the mycobacteria-elicited pulmonary granulomatous immune response in mice through DC-derived Notch ligand delta-like 4, J Clin Invest, vol.119, pp.33-46, 2009. ,
Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activation, J Immunol, vol.182, pp.7381-7389, 1950. ,
Human endothelial cells generate Th17 and regulatory T cells under inflammatory conditions, Proc Natl Acad Sci, vol.108, pp.2891-2897, 2011. ,