Granzyme B-secreting B cells as a potential cell therapeutic

Abstract : B cells secreting granzyme B (GZMB+) with suppressive properties have been discovered in a growing number of immunological contexts, autoimmunity, chronic infection, and neoplasias, as well as in healthy volunteers under physiological conditions. To date, no phenotype has been proposed for these GZMB+ B cells, and their biology also remains uncharacterized. These data provide new insights into GZMB+ B cell biology and function that emerge as one component of a complex regulatory network. Successfully expanding these cells while maintaining their potent immunosuppressive properties provides new clues for novel future cell therapies.
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Poster communications
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https://www.hal.inserm.fr/inserm-02161909
Contributor : Ana Paula Dutra Azevedo <>
Submitted on : Friday, June 21, 2019 - 11:29:06 AM
Last modification on : Friday, August 2, 2019 - 11:13:50 AM

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  • HAL Id : inserm-02161909, version 1

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Chesneau Mélanie, Danger Richard, Sabine Le Bot, Poulaouec Cyrielle, Filloux Matthieu, et al.. Granzyme B-secreting B cells as a potential cell therapeutic. FOCIS 2019, Jun 2019, Boston, United States. ⟨inserm-02161909⟩

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