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Conference poster

Granzyme B-secreting B cells as a potential cell therapeutic

Abstract : B cells secreting granzyme B (GZMB+) with suppressive properties have been discovered in a growing number of immunological contexts, autoimmunity, chronic infection, and neoplasias, as well as in healthy volunteers under physiological conditions. To date, no phenotype has been proposed for these GZMB+ B cells, and their biology also remains uncharacterized. These data provide new insights into GZMB+ B cell biology and function that emerge as one component of a complex regulatory network. Successfully expanding these cells while maintaining their potent immunosuppressive properties provides new clues for novel future cell therapies.
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Conference poster
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Contributor : Sylvie Le Bihan Connect in order to contact the contributor
Submitted on : Friday, June 21, 2019 - 11:29:06 AM
Last modification on : Thursday, November 24, 2022 - 4:06:43 AM


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  • HAL Id : inserm-02161909, version 1


Chesneau Mélanie, Danger Richard, Sabine Le Bot, Poulaouec Cyrielle, Filloux Matthieu, et al.. Granzyme B-secreting B cells as a potential cell therapeutic. FOCIS 2019, Jun 2019, Boston, United States. ⟨inserm-02161909⟩



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