Generation of Rag1 and Il2rg immunodeficient rats and application to humanization studies

Abstract : Modeling the immune response and rational immune approaches in vivo have relied heavily on studies performed in immunodeficient mouse models. These mouse models are groundbreaking platforms to humanize different tissues and organs and to evaluate compounds to treat a variety of human diseases, from cancer and infectious diseases to allergies, inflammation and GVHD. Rats are ideally suited to perform experiments in which larger size is needed and are still a small animal model suitable for rodent facilities. We describe here the generation of Il2rg-deficient rats and their crossing with previously described Rag1-deficient rats, generating for the first time double-mutant Rat Rag1 and Il2rG KO (RRG) animals.
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Poster communications
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https://www.hal.inserm.fr/inserm-02160389
Contributor : Ana Paula Dutra Azevedo <>
Submitted on : Wednesday, June 19, 2019 - 3:48:34 PM
Last modification on : Saturday, June 22, 2019 - 1:49:24 AM

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  • HAL Id : inserm-02160389, version 1

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Séverine Ménoret, Laure-Hélène Ouisse, L. Tesson, S. Remy, Claire Usal, et al.. Generation of Rag1 and Il2rg immunodeficient rats and application to humanization studies. The 3rd IGO SUMMER MEETING, Apr 2018, Nantes, France. ⟨inserm-02160389⟩

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