Identification of a common transcriptional signature for regulatory B cells in Humans and Mice
Résumé
Regulatory B cells (Bregs) have been described in mice and humans for their ability to regulate inflammation through a variety of mechanisms in different pathological situations. Up to date, no consensual and common Breg phenotype has been described, and whether there is a Breg lineage commitment or if they acquire their function under certain environmental conditions remains unknown. To address these points, we performed a sample size weighted meta-analysis of publicly available transcriptomic data from 4 different Bregs studies in humans and 6 Bregs studies in mice.
Domaines
Médecine humaine et pathologie
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