Identification of a common transcriptional signature for regulatory B cells in Humans and Mice

Florian Dubois; Sophie Limou; Mélanie Chesneau; Sophie Brouard; Richard Danger

Poster communications

Identification of a common transcriptional signature for regulatory B cells in Humans and Mice

Florian Dubois ^{1, 2} Sophie Limou ^{1, 2, 3} Mélanie Chesneau ^{1, 2} Sophie Brouard ^{1, 2, 4} Richard Danger ^{1, 2}

1 U1064 Inserm - CRTI - Centre de Recherche en Transplantation et Immunologie

2 ITUN - Institut de transplantation urologie-néphrologie

3 ECN - École Centrale de Nantes

4 CIC biothérapies CBT 0503 [Nantes]

Abstract : Regulatory B cells (Bregs) have been described in mice and humans for their ability to regulate inflammation through a variety of mechanisms in different pathological situations. Up to date, no consensual and common Breg phenotype has been described, and whether there is a Breg lineage commitment or if they acquire their function under certain environmental conditions remains unknown. To address these points, we performed a sample size weighted meta-analysis of publicly available transcriptomic data from 4 different Bregs studies in humans and 6 Bregs studies in mice.

Document type :

Poster communications

Domain :

Life Sciences [q-bio] / Human health and pathology

Complete list of metadatas

https://www.hal.inserm.fr/inserm-02160256
Contributor : Sylvie Le Bihan <>
Submitted on : Wednesday, June 19, 2019 - 2:41:11 PM
Last modification on : Thursday, June 20, 2019 - 1:35:38 AM

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