Abstract : Regulatory B cells (Bregs) have been described in mice and humans for their ability to regulate inflammation through a variety of mechanisms in different pathological situations. Up to date, no consensual and common Breg phenotype has been described, and whether there is a Breg lineage commitment or if they acquire their function under certain environmental conditions remains unknown. To address these points, we performed a sample size weighted meta-analysis of publicly available transcriptomic data from 4 different Bregs studies in humans and 6 Bregs studies in mice.
https://www.hal.inserm.fr/inserm-02160256
Contributor : Ana Paula Dutra Azevedo
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Submitted on : Wednesday, June 19, 2019 - 2:41:11 PM
Last modification on : Thursday, June 20, 2019 - 1:35:38 AM
Florian Dubois, Sophie Limou, Mélanie Chesneau, Sophie Brouard, Richard Danger. Identification of a common transcriptional signature for regulatory B cells in Humans and Mice. FOCIS 2019, Jun 2019, Boston, United States. ⟨inserm-02160256⟩
