Expanded human CD8+CD45RClowFoxp3+ Tregs secreting IFNγ, IL-10, IL-34 and TGFβinhibit human transplant rejection

Abstract : Tregs play a critical role in the control of immune responses and tolerance induction; however our understanding of CD8+ Tregs is limited while they are particularly promising for therapeutic application. We previously reported that CD8+CD45RC[low] Tregs use IFNγ and IL-34 to suppress donor responses in a rat model of allotransplantation (Guillonneau et al, JCI, 2007 ; Bezieetal, JCI, 2015). Here, we aim to characterize human CD8+ Tregs to assess their potential for cell therapy in transplantation in comparison to CD4+CD25[high]CD127- Tregs .
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https://www.hal.inserm.fr/inserm-02159985
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Submitted on : Wednesday, June 19, 2019 - 11:24:22 AM
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Séverine Bézie, Dimitri Meistermann, Laetitia Boucault, Stephanie Kilens, Johanna Zoppi, et al.. Expanded human CD8+CD45RClowFoxp3+ Tregs secreting IFNγ, IL-10, IL-34 and TGFβinhibit human transplant rejection. FOCIS, Jun 2017, Chicago, United States. ⟨inserm-02159985⟩

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