Expanded human CD8+CD45RClowFoxp3+ Tregs secreting IFNγ, IL-10, IL-34 and TGFβinhibit human transplant rejection

Séverine Bézie; Dimitri Meistermann; Laetitia Boucault; Stephanie Kilens; Johanna Zoppi; Elodie Autrusseau; Audrey Donnart; Véronique Daguin; Frédérique Bellier-Waast; Eric Charpentier; Franck Duteille; Laurent David; Ignacio Anegon; Carole Guillonneau

Expanded human CD8+CD45RClowFoxp3+ Tregs secreting IFNγ, IL-10, IL-34 and TGFβinhibit human transplant rejection

Séverine Bézie ^{1, 2} Dimitri Meistermann ^{1, 2} Laetitia Boucault ^{1, 2} Stephanie Kilens ^{1, 2} Johanna Zoppi ^{1, 2} Elodie Autrusseau ^{1, 2} Audrey Donnart ³ Véronique Daguin ^{1, 2} Frédérique Bellier-Waast ⁴ Eric Charpentier ³ Franck Duteille ⁴ Laurent David ^{1, 2} Ignacio Anegon ^{1, 2} Carole Guillonneau ^{1, 2}

1 U1064 Inserm - CRTI - Centre de Recherche en Transplantation et Immunologie

2 ITUN - Institut de transplantation urologie-néphrologie

3 ITX - unité de recherche de l'institut du thorax UMR1087 UMR6291

4 Chirurgie Plastique Reconstructrice et Esthétique [CHU Nantes]

Abstract : Tregs play a critical role in the control of immune responses and tolerance induction; however our understanding of CD8+ Tregs is limited while they are particularly promising for therapeutic application. We previously reported that CD8+CD45RC[low] Tregs use IFNγ and IL-34 to suppress donor responses in a rat model of allotransplantation (Guillonneau et al, JCI, 2007 ; Bezieetal, JCI, 2015). Here, we aim to characterize human CD8+ Tregs to assess their potential for cell therapy in transplantation in comparison to CD4+CD25[high]CD127- Tregs .

Document type :

Poster communications

Domain :

Life Sciences [q-bio] / Human health and pathology

Complete list of metadatas

https://www.hal.inserm.fr/inserm-02159985
Contributor : Ana Paula Dutra Azevedo <>
Submitted on : Wednesday, June 19, 2019 - 11:24:22 AM
Last modification on : Monday, October 28, 2019 - 2:30:34 PM

poster FOCIS 2017 final (1) (1...

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Expanded human CD8+CD45RClowFoxp3+ Tregs secreting IFNγ, IL-10, IL-34 and TGFβinhibit human transplant rejection

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Expanded human CD8+CD45RClowFoxp3+ Tregs secreting IFNγ, IL-10, IL-34 and TGFβinhibit human transplant rejection

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