Expansion of natural CD8+Tregs for cell therapy

Abstract : Tregs play a critical role in the control of immune responses and tolerance induction; however our understanding of CD8+ Tregs is limited while they are particularly promising for therapeutic application. We previously reported that CD8+CD45RC[low] Tregs use IFNγ and IL-34 to suppress donor responses in a rat model of allotransplantation (Guillonneau et al, JCI, 2007; Bezie et al, JCI, 2015). Here, we aim to characterize human CD8+ Tregs to assess their potential for cell therapy in transplantation.
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https://www.hal.inserm.fr/inserm-02159875
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Submitted on : Wednesday, June 19, 2019 - 9:54:46 AM
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  • HAL Id : inserm-02159875, version 1

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Séverine Bézie, Dimitri Meistermann, Laetitia Boucault, Stéphanie Kilens, Johanna Zoppi, et al.. Expansion of natural CD8+Tregs for cell therapy. Labex IGO, Apr 2018, Nantes, France. ⟨inserm-02159875⟩

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