Alteration of CD8+ CD45RC[int/neg] regulatory T cells functions in Multiple Sclerosis and correlates with disease severity

Abstract : Autoimmune diseases can develop following pathological activation of autoreactive effector cells and/or, alternatively, after weakening of self-protective regulatory mechanisms. Most of the studies have focused on CD4+ Tregs and the role of CD8+ Tregs in Multiple Sclerosis (MS) remains largely unexplored. We previously reported the suppressive properties of rat and human CD8+CD45RCint/neg Treg cells, expressing Foxp3 and acting through IFNg, TGFb and IL34 cytokines (Guillonneau, JCI, 2007; Bézie, JCI, 2015, Bézie, Front. Immunol., 2018). Thus, their potency of suppression make them strong candidates of disruptive immune tolerance, especially in MS where CD8+ T cells play a major role. Thus, the overreaching goal of this study is to define the role of CD8+ regulatory T cell in MS pathogenesis.
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https://www.hal.inserm.fr/inserm-02159755
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Submitted on : Wednesday, June 19, 2019 - 8:22:17 AM
Last modification on : Thursday, June 20, 2019 - 1:35:37 AM

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Naïl Benallegue, Bryan Nicol, Séverine Bézie, Hadrien Regue, Nadège Vimont, et al.. Alteration of CD8+ CD45RC[int/neg] regulatory T cells functions in Multiple Sclerosis and correlates with disease severity. ECTRIMS 2018 (34th congress of the european committee for treatment and research in Multiple Sclerosis), Oct 2018, Berlin, Germany. ⟨inserm-02159755⟩

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