Liver-specific RORα deletion does not affect the metabolic susceptibility to western style diet feeding

The nuclear receptor superfamily is a potential target for the development of new treatments for obesity and metabolic diseases. Increasing evidence has pointed towards the retinoic acid-related orphan receptor-alpha (RORα) as an important nuclear receptor involved in several biological processes. RORα full body knockout mice display improved metabolic phenotypes on both chow and high fat (60% fat, 20% carbohydrate) diets, but also have severe behavioral abnormalities. Here we investigated the effect of hepatic RORα by generating mice with liver-specific RORα deletion to elucidate the role of this nuclear receptor on host metabolism.

Mots clés

Obesity Glucose metabolism Steatosis RORα RORa

Domaines

Sciences du Vivant [q-bio] Médecine humaine et pathologie

Fichier principal

Molinaro Mol Metab.pdf (1.02 Mo)

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Marie-Hélène Derudas : Connectez-vous pour contacter le contributeur

https://inserm.hal.science/inserm-02158994

Soumis le : mardi 18 juin 2019-14:27:34

Dernière modification le : mercredi 24 janvier 2024-09:54:21

Dates et versions

inserm-02158994 , version 1 (18-06-2019)

Identifiants

HAL Id : inserm-02158994 , version 1
DOI : 10.1016/j.molmet.2019.02.010
PUBMED : 30904385

Citer

Antonio Molinaro, Robert Caesar, Laurent L'Homme, Ara Koh, Marcus Ståhlman, et al.. Liver-specific RORα deletion does not affect the metabolic susceptibility to western style diet feeding. Molecular metabolism, 2019, 23, pp.82-87. ⟨10.1016/j.molmet.2019.02.010⟩. ⟨inserm-02158994⟩

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