Liver-specific RORα deletion does not affect the metabolic susceptibility to western style diet feeding

Abstract : The nuclear receptor superfamily is a potential target for the development of new treatments for obesity and metabolic diseases. Increasing evidence has pointed towards the retinoic acid-related orphan receptor-alpha (RORα) as an important nuclear receptor involved in several biological processes. RORα full body knockout mice display improved metabolic phenotypes on both chow and high fat (60% fat, 20% carbohydrate) diets, but also have severe behavioral abnormalities. Here we investigated the effect of hepatic RORα by generating mice with liver-specific RORα deletion to elucidate the role of this nuclear receptor on host metabolism.
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Submitted on : Tuesday, June 18, 2019 - 2:27:34 PM
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Antonio Molinaro, Robert Caesar, Laurent l'Homme, Ara Koh, Marcus Ståhlman, et al.. Liver-specific RORα deletion does not affect the metabolic susceptibility to western style diet feeding. Molecular metabolism, Elsevier, 2019, 23, pp.82-87. ⟨10.1016/j.molmet.2019.02.010⟩. ⟨inserm-02158994⟩

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