Liver-specific RORα deletion does not affect the metabolic susceptibility to western style diet feeding - Archive ouverte HAL Access content directly
Journal Articles Molecular metabolism Year : 2019

Liver-specific RORα deletion does not affect the metabolic susceptibility to western style diet feeding

(1) , (1) , (2) , (1) , (1) , (2) , (3, 4)
1
2
3
4

Abstract

The nuclear receptor superfamily is a potential target for the development of new treatments for obesity and metabolic diseases. Increasing evidence has pointed towards the retinoic acid-related orphan receptor-alpha (RORα) as an important nuclear receptor involved in several biological processes. RORα full body knockout mice display improved metabolic phenotypes on both chow and high fat (60% fat, 20% carbohydrate) diets, but also have severe behavioral abnormalities. Here we investigated the effect of hepatic RORα by generating mice with liver-specific RORα deletion to elucidate the role of this nuclear receptor on host metabolism.
Fichier principal
Vignette du fichier
Molinaro Mol Metab.pdf (1.02 Mo) Télécharger le fichier
Origin : Publication funded by an institution
Loading...

Dates and versions

inserm-02158994 , version 1 (18-06-2019)

Identifiers

Cite

Antonio Molinaro, Robert Caesar, Laurent L'Homme, Ara Koh, Marcus Ståhlman, et al.. Liver-specific RORα deletion does not affect the metabolic susceptibility to western style diet feeding. Molecular metabolism, 2019, 23, pp.82-87. ⟨10.1016/j.molmet.2019.02.010⟩. ⟨inserm-02158994⟩
21 View
152 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More