Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization
Anke Fuchs
(1)
,
Mateusz Gliwiński
(2)
,
Nathali Grageda
(3)
,
Rachel Spiering
(4)
,
Abul K Abbas
(5)
,
Silke Appel
(6)
,
Rosa Bacchetta
(7)
,
Manuela Battaglia
(8)
,
David Berglund
(9)
,
Bruce Blazar
(10)
,
Jeffrey A. Bluestone
(5)
,
Martin Bornhäuser
(1)
,
Anja ten Brinke
(11)
,
Todd M Brusko
(12)
,
Nathalie Cools
(13, 14)
,
Maria Cristina Cuturi
(15)
,
Edward Geissler
(16)
,
Nick Giannoukakis
(17)
,
Karolina Gołab
(18)
,
David A Hafler
(19)
,
S Marieke van Ham
(11)
,
Joanna Hester
(20)
,
Keli Hippen
(10)
,
Mauro Di Ianni
(21)
,
Natasa Ilic
(22)
,
John Isaacs
(4, 23)
,
Fadi Issa
(20)
,
Dorota Iwaszkiewicz-Grześ
(2)
,
Elmar Jaeckel
(24)
,
Irma Joosten
(25)
,
David Klatzmann
(26)
,
Hans Koenen
(25)
,
Cees van Kooten
(27)
,
Olle Korsgren
(28, 29)
,
Karsten Kretschmer
(30, 31)
,
Megan Levings
(32)
,
Natalia Maria Marek-Trzonkowska
(2)
,
Marc Martinez-Llordella
(3)
,
Djordje Miljkovic
(22)
,
Kingston H G Mills
(33)
,
Joana P Miranda
(34)
,
Ciriaco A Piccirillo
(35)
,
Amy L Putnam
(5)
,
Thomas Ritter
(36)
,
Maria Grazia Roncarolo
(37)
,
Shimon Sakaguchi
(38)
,
Silvia Sánchez-Ramón
(39)
,
Birgit Sawitzki
(40)
,
Ljiljana Sofronic-Milosavljevic
(22)
,
Megan Sykes
(41)
,
Qizhi Tang
(5)
,
Marta Vives-Pi
(42)
,
Herman Waldmann
(20)
,
Piotr Witkowski
(43)
,
Kathryn Wood
(20)
,
Silvia Gregori
(8)
,
Catharien M U Hilkens
(4)
,
Giovanna Lombardi
(3)
,
Phillip Lord
(4)
,
Eva M Martinez-Caceres
(42, 44)
,
Piotr Trzonkowski
(2)
1
Medical Faculty -
CRTD-DFG Research Center for Regenerative Therapies Dresden [Dresden, Germany]
2 Medical University of Gdańsk
3 King‘s College London
4 Newcastle University [Newcastle]
5 UC San Francisco - University of California [San Francisco]
6 UiB - University of Bergen
7 Stanford School of Medicine [Stanford]
8 IRCCS Ospedale San Raffaele [Milan, Italy]
9 Uppsala University
10 UMN - University of Minnesota [Twin Cities]
11 UvA - University of Amsterdam [Amsterdam] = Universiteit van Amsterdam
12 UF - University of Florida [Gainesville]
13 UA - University of Antwerp
14 UZA - Antwerp University Hospital [Edegem]
15 Team 1 - U1064 Inserm - CRTI - Dendritic cells and immunoregulation in transplantation and immunopathology
16 University Hospital Regensburg
17 CMU - Carnegie Mellon University [Pittsburgh]
18 University of Chicago
19 YSM - Yale School of Medicine [New Haven, Connecticut]
20 University of Oxford
21 University of Chieti-Pescara
22 University of Belgrade [Belgrade]
23 NHS Foundation Trust [London]
24 MHH - Medizinische Hochschule Hannover = Hannover Medical School
25 Radboud University Medical Center [Nijmegen]
26 I3 - Immunologie - Immunopathologie - Immunothérapie [CHU Pitié Salpêtrière]
27 LUMC - Leiden University Medical Center
28 Uppsala University Hospital
29 GU - Göteborgs Universitet = University of Gothenburg
30 TU Dresden - Technische Universität Dresden = Dresden University of Technology
31 Helmholtz Zentrum München = German Research Center for Environmental Health
32 BCCHR - BC Children's Hospital Research Institute [Vancouver, BC, Canada]
33 Trinity College Dublin
34 ULISBOA - Universidade de Lisboa = University of Lisbon
35 McGill University = Université McGill [Montréal, Canada]
36 NUI Galway - National University of Ireland [Galway]
37 Stanford University School of Medicine [CA, USA]
38 Osaka University [Osaka]
39 Department of Clinical Immunology, Hospital Clínico San Carlos
40 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
41 Columbia University [New York]
42 IGTP - Institut d’Investigació Germans Trias i Pujol = Germans Trias i Pujol Research Institute
43 The University of Chicago Medicine [Chicago]
44 UAB - Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
2 Medical University of Gdańsk
3 King‘s College London
4 Newcastle University [Newcastle]
5 UC San Francisco - University of California [San Francisco]
6 UiB - University of Bergen
7 Stanford School of Medicine [Stanford]
8 IRCCS Ospedale San Raffaele [Milan, Italy]
9 Uppsala University
10 UMN - University of Minnesota [Twin Cities]
11 UvA - University of Amsterdam [Amsterdam] = Universiteit van Amsterdam
12 UF - University of Florida [Gainesville]
13 UA - University of Antwerp
14 UZA - Antwerp University Hospital [Edegem]
15 Team 1 - U1064 Inserm - CRTI - Dendritic cells and immunoregulation in transplantation and immunopathology
16 University Hospital Regensburg
17 CMU - Carnegie Mellon University [Pittsburgh]
18 University of Chicago
19 YSM - Yale School of Medicine [New Haven, Connecticut]
20 University of Oxford
21 University of Chieti-Pescara
22 University of Belgrade [Belgrade]
23 NHS Foundation Trust [London]
24 MHH - Medizinische Hochschule Hannover = Hannover Medical School
25 Radboud University Medical Center [Nijmegen]
26 I3 - Immunologie - Immunopathologie - Immunothérapie [CHU Pitié Salpêtrière]
27 LUMC - Leiden University Medical Center
28 Uppsala University Hospital
29 GU - Göteborgs Universitet = University of Gothenburg
30 TU Dresden - Technische Universität Dresden = Dresden University of Technology
31 Helmholtz Zentrum München = German Research Center for Environmental Health
32 BCCHR - BC Children's Hospital Research Institute [Vancouver, BC, Canada]
33 Trinity College Dublin
34 ULISBOA - Universidade de Lisboa = University of Lisbon
35 McGill University = Université McGill [Montréal, Canada]
36 NUI Galway - National University of Ireland [Galway]
37 Stanford University School of Medicine [CA, USA]
38 Osaka University [Osaka]
39 Department of Clinical Immunology, Hospital Clínico San Carlos
40 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
41 Columbia University [New York]
42 IGTP - Institut d’Investigació Germans Trias i Pujol = Germans Trias i Pujol Research Institute
43 The University of Chicago Medicine [Chicago]
44 UAB - Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
David Klatzmann
- Fonction : Auteur
- PersonId : 757052
- ORCID : 0000-0002-0054-3422
- IdRef : 069959846
Silvia Sánchez-Ramón
- Fonction : Auteur
- PersonId : 990441
Birgit Sawitzki
- Fonction : Auteur
- PersonId : 1048483
Résumé
Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety of autoimmune and allergic diseases as well as posttransplant complications. Nevertheless, current manufacturing of Tregs as a cellular medicinal product varies between different laboratories, which in turn hampers precise comparisons of the results between the studies performed. While the number of clinical trials testing Tregs is already substantial, it seems to be crucial to provide some standardized characteristics of Treg products in order to minimize the problem. We have previously developed reporting guidelines called minimum information about tolerogenic antigen-presenting cells, which allows the comparison between different preparations of tolerance-inducing antigen-presenting cells. Having this experience, here we describe another minimum information about Tregs (MITREG). It is important to note that MITREG does not dictate how investigators should generate or characterize Tregs, but it does require investigators to report their Treg data in a consistent and transparent manner. We hope this will, therefore, be a useful tool facilitating standardized reporting on the manufacturing of Tregs, either for research purposes or for clinical application. This way MITREG might also be an important step toward more standardized and reproducible testing of the Tregs preparations in clinical applications.
Origine : Publication financée par une institution