M. K. Zeman and K. A. Cimprich, Causes and consequences of replication stress, Nat Cell Biol, vol.16, issue.1, p.24366029, 2014.

M. Macheret and T. D. Halazonetis, DNA replication stress as a hallmark of cancer, Annu Rev Pathol, vol.10, p.25621662, 2015.

J. C. Saldivar, D. Cortez, and K. A. Cimprich, The essential kinase ATR: ensuring faithful duplication of a challenging genome, Nat Rev Mol Cell Biol, p.28811666, 2017.

E. Petermann, M. L. Orta, N. Issaeva, N. Schultz, and T. Helleday, Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair

, Epub 2010/03/02, vol.37, p.2958316, 2010.

K. Hanada, M. Budzowska, S. L. Davies, E. Van-drunen, H. Onizawa et al., The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks, Nat Struct Mol Biol, vol.14, issue.11, pp.1096-104, 2007.

M. Regairaz, Y. W. Zhang, H. Fu, K. K. Agama, N. Tata et al., Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I-DNA complexes, J Cell Biol, vol.195, issue.5, p.3257568, 2011.

B. Pfander and J. Matos, Control of Mus81 nuclease during the cell cycle, FEBS Lett, vol.591, issue.14, p.28640495, 2017.

V. Bergoglio, A. S. Boyer, E. Walsh, V. Naim, G. Legube et al., DNA synthesis by Pol eta promotes fragile site stability by preventing under-replicated DNA in mitosis, J Cell Biol, vol.201, issue.3, p.3639397, 2013.

S. Minocherhomji, S. Ying, V. A. Bjerregaard, S. Bursomanno, A. Aleliunaite et al., Replication stress activates DNA repair synthesis in mitosis, Nature, vol.528, issue.7581, pp.286-90, 2015.

V. Naim, T. Wilhelm, M. Debatisse, and F. Rosselli, ERCC1 and MUS81-EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis, Nat Cell Biol, vol.15, issue.8, 2013.

S. Ying, S. Minocherhomji, K. L. Chan, T. Palmai-pallag, W. K. Chu et al., MUS81 promotes common fragile site expression, Nat Cell Biol, vol.15, issue.8, pp.1001-1008, 2013.

H. Duda, M. Arter, J. Gloggnitzer, F. Teloni, P. Wild et al., A Mechanism for Controlled Breakage of Under-replicated Chromosomes during Mitosis, Dev Cell, vol.40, issue.4, p.28245925, 2017.

B. M. Sirbu, F. B. Couch, J. T. Feigerle, S. Bhaskara, S. W. Hiebert et al., Analysis of protein dynamics at active, stalled, and collapsed replication forks, Genes Dev, vol.25, issue.12, p.3127432, 2011.

L. I. Toledo, M. Altmeyer, M. B. Rask, C. Lukas, D. H. Larsen et al., ATR prohibits replication catastrophe by preventing global exhaustion of RPA, Cell, vol.155, issue.5, p.24267891, 2013.

J. H. Lee, H. M. Cheong, M. Y. Kang, S. Y. Kim, and Y. Kang, Ser1778 of 53BP1 Plays a Role in DNA Double-strand Break Repairs, Korean J Physiol Pharmacol, vol.13, issue.5, p.2776893, 2009.

D. Moshous, I. Callebaut, R. De-chasseval, B. Corneo, M. Cavazzana-calvo et al., Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency, Cell, vol.105, issue.2, p.11336668, 2001.

A. Ahmad, J. H. Enzlin, N. R. Bhagwat, N. Wijgers, A. Raams et al., Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients, PLoS Genet, vol.6, issue.3, p.2832669, 2010.

K. H. Leung, A. E. Hassan, M. Bremner, and R. , A rapid and efficient method to purify proteins at replication forks under native conditions, Biotechniques, vol.55, issue.4, pp.204-210, 2013.

A. A. Goodarzi, Y. Yu, E. Riballo, P. Douglas, S. A. Walker et al., DNA-PK autophosphorylation facilitates Artemis endonuclease activity, EMBO J, vol.25, issue.16, p.1553186, 2006.

J. H. Guervilly, A. Takedachi, V. Naim, S. Scaglione, C. Chawhan et al., The SLX4 complex is a SUMO E3 ligase that impacts on replication stress outcome and genome stability, Mol Cell, vol.57, issue.1, p.25533188, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01429041

J. Unno, M. Takagi, J. Piao, M. Sugimoto, F. Honda et al., Artemis-dependent DNA doublestrand break formation at stalled replication forks, Cancer Sci, vol.104, issue.6, p.23465063, 2013.

J. T. Yeeles, J. Poli, K. J. Marians, and P. Pasero, Rescuing stalled or damaged replication forks, Cold Spring Harb Perspect Biol, vol.5, issue.5, p.23637285, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00820216

R. Zellweger, D. Dalcher, K. Mutreja, M. Berti, J. A. Schmid et al., Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells, J Cell Biol, vol.208, issue.5, p.4347635, 2015.

R. Mayle, I. M. Campbell, C. R. Beck, Y. Yu, M. Wilson et al., DNA REPAIR. Mus81 and converging forks limit the mutagenicity of replication fork breakage, Science, vol.349, issue.6249, p.4782627, 2015.

L. Costantino, S. K. Sotiriou, J. K. Rantala, S. Magin, E. Mladenov et al., Break-induced replication repair of damaged forks induces genomic duplications in human cells, Science, vol.343, issue.6166, p.4047655, 2014.

S. K. Sotiriou, I. Kamileri, N. Lugli, K. Evangelou, C. Da-re et al., Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks, Mol Cell, vol.64, issue.6, p.5179496, 2016.

N. Crosetto, A. Mitra, M. J. Silva, M. Bienko, N. Dojer et al., Nucleotide-resolution DNA doublestrand break mapping by next-generation sequencing, Nat Methods, vol.10, issue.4, p.3651036, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00820214

J. Sollier, C. T. Stork, M. L. Garcia-rubio, R. D. Paulsen, A. Aguilera et al., Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability, Mol Cell, vol.56, issue.6, p.4272638, 2014.

A. Fernandez-vidal, L. Guitton-sert, J. C. Cadoret, M. Drac, E. Schwob et al., A role for DNA polymerase theta in the timing of DNA replication, Nat Commun, vol.5, p.4285, 2014.