Skip to Main content Skip to Navigation
Journal articles

Lipoxin A[4] Attenuates the Inflammatory Response in Stem Cells of the Apical Papilla via ALX/FPR2

Abstract : Similar to the onset phase of inflammation, its resolution is a process that unfolds in a manner that is coordinated and regulated by a panel of mediators. Lipoxin A4 (LXA4) has been implicated as an anti-inflammatory, pro-resolving mediator. We hypothesized that LXA4 attenuates or prevents an inflammatory response via the immunosuppressive activity of Stem Cells of the Apical Papilla (SCAP). Here, we report for the first time in vitro that in a SCAP population, lipoxin receptor ALX/FPR2 was constitutively expressed and upregulated after stimulation with lipopolysaccharide and/or TNF-α. Moreover, LXA4 significantly enhanced proliferation, migration, and wound healing capacity of SCAP through the activation of its receptor, ALX/FPR2. Cytokine, chemokine and growth factor secretion by SCAP was inhibited in a dose dependent manner by LXA4. Finally, LXA4 enhanced immunomodulatory properties of SCAP towards Peripheral Blood Mononuclear Cells. These findings provide the first evidence that the LXA4-ALX/FPR2 axis in SCAP regulates inflammatory mediators and enhances immunomodulatory properties. Such features of SCAP may also support the role of these cells in the resolution phase of inflammation and suggest a novel molecular target for ALX/FPR2 receptor to enhance a stem cell-mediated pro-resolving pathway.
Document type :
Journal articles
Complete list of metadata

Cited literature [48 references]  Display  Hide  Download
Contributor : Sylvie Le Bihan Connect in order to contact the contributor
Submitted on : Monday, June 17, 2019 - 11:52:13 AM
Last modification on : Wednesday, April 27, 2022 - 4:17:42 AM


Publication funded by an institution



Alexis Gaudin, M. Tolar, O. A. Peters. Lipoxin A[4] Attenuates the Inflammatory Response in Stem Cells of the Apical Papilla via ALX/FPR2. Scientific Reports, Nature Publishing Group, 2018, 8 (1), pp.8921. ⟨10.1038/s41598-018-27194-7⟩. ⟨inserm-02157698⟩



Record views


Files downloads